Cognitive control subprocess deficits and compensatory modulation mechanisms in patients with frontal lobe injury revealed by EEG markers:a basic study to guide brain stimulation
作者机构：Department of Forensic MedicineSchool of Basic Medicine and Biological SciencesAffiliated Guangji HospitalSoochow UniversitySuzhouJiangsuChina Department of Forensic MedicineInstitute of Forensic Medicine and Laboratory MedicineJining Medical UniversityJiningShandongChina Department of PathologyForensic and Pathology LaboratoryInstitute of Forensic ScienceJiaxing UniversityJiaxingZhejiangChina
出 版 物：《General Psychiatry》 (综合精神医学（英文）)
年 卷 期：2023年第36卷第4期
页 面：260-272页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(82271933,81971800 and 81871536) Priority Academic Program Development of Jiangsu Higher Education Institutes(PAPD)(SYSD2012063) Shandong Provincial Natural Science Foundation(ZR2023QH434),China
主 题：connectivity EEG network
摘 要：Background Frontal lobe injury(FLI)is related to cognitive control impairments,but the influences of FLI on the internal subprocesses of cognitive control remain *** We sought to identify specific biomarkers for long-term dysfunction or compensatory modulation in different cognitive control *** A retrospective case-control study was ***-related potentials(ERP),oscillations and functional connectivity were used to analyse electroencephalography(EEG)data from 12 patients with unilateral frontal lobe injury(UFLI),12 patients with bilateral frontal lobe injury(BFLI)and 26 healthy controls(HCs)during a Go/NoGo task,which included several subprocesses:perceptual processing,anticipatory preparation,conflict monitoring and response *** Compared with the HC group,N2(the second negative peak in the averaged ERP waveform)latency,and frontal and parietal oscillations were decreased only in the BFLI group,whereas P3(the third positive peak in the averaged ERP waveform)amplitudes and sensorimotor oscillations were decreased in both patient *** functional connectivity of the four subprocesses was as follows:alpha connections of posterior networks in the BFLI group were lower than in the HC and UFLI groups,and these alpha connections were negatively correlated with neuropsychological *** connections of the dorsal frontoparietal network in the bilateral hemispheres of the BFLI group were lower than in the HC and UFLI groups,and these connections in the uninjured hemisphere of the UFLI group were higher than in the HC group,which were negatively correlated with behavioural *** and theta connections of the midfrontal-related networks in the BFLI group were lower than in the HC *** across-network connections in the HC group were higher than in the BFLI group but lower than in the UFLI *** The enhancement of low-frequency connections reflects compensatory *** contrast,alpha c
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