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food science and Human Wellness 2023年第4期12卷 1351-1358页

作者： Huilin Yu Junhui Zhang Yan Zhao Honghao Li Yixuan Chen Jiajin Zhu Department of Food Science and Nutrition Zhejiang UniversityHangzhou 310058China

The contamination of Atlantic salmon with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has impeded the development of the cold-chain food industry and posed possible risks to the population.Electron beam(E-beam)irradiation under 2,4,7,and 10 kGy can effectively inactivate SARS-CoV-2 in cold-chain seafood.However,there are few statistics about the quality changes of salmon exposed to these irradiation dosages.This work demonstrated that E-beam irradiation at dosages capable of killing SARS-CoV-2 induced lipid oxidation,decreased vitamin A content,and increased some amino acids and ash content.In addition,irradiation altered the textural features of salmon,such as its hardness,resilience,cohesiveness,and chewiness.The irradiation considerably affected the L*,a*,and b*values of salmon,with the L*value increasing and a*,b*values decreasing.There was no significant difference in the sensory evaluation of control and irradiated salmon.It was shown that irradiation with 2−7 kGy E-beam did not significantly degrade quality.The inactivation of SARS-CoV-2 in salmon is advised at a dose of 2 kGy.

关键词： E-beam irradiation Atlantic salmon SARS-CoV-2 Physicochemical properties

Special issue:molecular nutrition and chronic diseases

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2023年第7期24卷 549-553页

作者： Wei CHEN Hongming SU Department of Food Science and Nutrition Zhejiang UniversityHangzhou 310058China2.Department of Food Science and NutritionUniversity of Minnesota-Twin CitiesSaint Paul 55108USA

"Let food be thy medicine and medicine be thy food"—the ancient adage proposed by Greek philoso-pher Hippocrates of Kos thousands of years ago al-ready acknowledged the importance of the beneficial and health-promoting effects of food nutrients on the body(Mafra et al.,2021).Recent epidemiological and large-scale community studies have also reported that unhealthy diets or eating habits may contribute heavily to the burden of chronic,non-communicable diseases,such as obesity,type 2 diabetes mellitus(T2DM),hypertension,cardiovascular disease(CVD),cancer,neurodegenerative diseases,arthritis,chronic kidney disease(CKD),and chronic obstructive pulmonary disease(COPD)(Jayedi et al.,2020;Gao et al.,2022).Emerging evidence highlights that a diet rich in fruits and vegetables can prevent various chronic diseases(Chen et al.,2022).food bioactive compounds includ-ing vitamins,phytochemicals,and dietary fibers are responsible for these nutraceutical benefits.

关键词： diseases vitamin nutrition

Antioxidant capacity and phytochemical content of 16 sources of corn distillers dried grains with solubles(DDGS)

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Animal nutrition 2018年第4期4卷 435-441页

作者： Eui-Cheol Shin Gerald C.Shurson Daniel D.Gallaher Department of Food Science and Nutrition University of Minnesota department of Animal science University of Minnesota

Corn distillers dried grains with solubles(DDGS) is a co-product of the fuel ethanol industry that is an excellent source of energy, digestible amino acids, and digestible phosphorus. However, the antioxidant capacity and phytochemical content of DDGS and how it is influenced by production parameters is unknown. Therefore, 16 DDGS samples obtained from different ethanol production plants in the U.S.were characterized for antioxidant capacity, vitamin E, xanthophylls, and ferulic acid content and compared with corn. The antioxidant capacity of DDGS samples, measured using the 2,2-diphenyl-lpicrylhydrazyl(DPPH) assay, varied almost 2 folds among samples, but in all cases was more than 3 times that of corn. All DDGS samples had a considerably greater concentration of tocopherols and tocotrienols(lipid-soluble antioxidants) than corn. However, the relative concentrations among the tocopherols and tocotrienols tended to be similar to corn. The xanthophyll lutein was present in all DDGS samples and in all cases exceeded the content in corn. Zeaxanthin was detected in most samples. The total ferulic acid content of the DDGS samples was almost 3-fold greater than corn, but, as in corn, almost all was present in a bound form. However, the concentration of unbound(free) ferulic acid was more than 3 times the concentration found in the corn sample. Thus, DDGS is a rich source of phytochemical compounds and may provide antioxidant and health benefits beyond its macronutrient composition. However, differences in processing can greatly influence the phytochemical content and quality of DDGS. In particular,thermal abuse due to excessive heat used in drying may lead to lipid oxidation products that may have deleterious effects when incorporated into feeds.

关键词： Corn distillers dried grains with solubles Vitamin E Ferulic acid Xanthophylls Lutein Antioxidant capacity

Effects of edible whole citrus fruits on endogenous antioxidant enzymes of HepG2 cells

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food Quality and Safety 2022年第2期6卷 310-317页

作者：孙玉敬刘苗苗陶文扬叶兴乾孙培龙 College of food science and Technology Zhejiang University of TechnologyHangzhouChina Department of Food Science and Nutrition School of Biosystems Engine ering and Food ScienceZhejiang UniversityHangzhouChina

The effects of eating fresh citrus fruits including two varieties of mandarins,one of sweet oranges,one of grapefruit,two of pomelo,and one of kumquat cultivated in China on endogenous antioxidant enzymes were investigated by in vitro digestion and HepG2 cells.The correlations between enzyme activity and cell uptake of phytochemicals and cellular antioxidant capacities were analyzed.The results showed that most fresh citrus fruits increased the endogenous antioxidant activity.Bairoumiyou,Hongroumiyou,Ponkan,and Jinju after digestion significantly increased the activity of catalase(P<0.05).Hongroumiyou,Bairoumiyou,Ponkan navel orange,and Jinju after digestion significantly increased glutathione peroxidases(GPxs)activity(P<0.05),while Huyou and satsuma could not increase the activity of GPxs after digestion.Thioredoxin oxidoreductase activity was improved significantly by most of the digested whole citrus fruits except Ponkan(P<0.05)and thioredoxin oxidoreductase added whole citrus fruits had a higher increase than added citrus fruits extracts.The results indicated that edible whole citrus fruits had similar effects as extracts on enzymes.

关键词： Citrus fruit endogenous antioxidant enzymes in vitro digestion polyphenols carotenoids

Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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food science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang Jinlong Tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li department of food science College of FoodShenyang Agricultural UniversityShenyang 110161China Department of Food Science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic acid.Because of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy diseases.This study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human body.On this basis,the disease control functions that have been proved effective in clinical research were reviewed and analyzed.These studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and inflammation.Because there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

Dopamine as a growth differentiation factor in the mammalian brain

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Neural Regeneration Research 2020年第3期15卷 390-393页

作者： Koji Ohira Laboratory of nutritional Brain science Department of Food Science and Nutrition Mukogawa Women’s University

The catecholamine,dopamine,plays an important role in the central nervous system of mammals,including executive functions,motor control,motivation,arousal,reinforcement,and reward.Dysfunctions of the dopaminergic system lead to diseases of the brains,such as Parkinson’s disease,Tourette’s syndrome,and schizophrenia.In addition to its fundamental role as a neurotransmitter,there is evidence for a role as a growth differentiation factor during development.Recent studies suggest that dopamine regulates the development ofγ-aminobutyric acidergic interneurons of the cerebral cortex.Moreover,in adult brains,dopamine increases the production of new neurons in the hippocampus,suggesting the promoting effect of dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult brains.In this mini-review,I center my attention on dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.

关键词： γ-aminobutyric acidergic interneuron adult neurogenesis cerebral cortex dopamine GABA medial ganglionic eminence migration striatum

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1117-1122页

作者： Prashamsa Koirala Su Hui Seong Hyun Ah Jung Jae Sue Choi department of food and Life science Pukyong National University department of food science and Human nutrition Chonbuk National University

Objective: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against b-site amyloid precursor protein cleaving enzyme 1(BACE1), which serve as a rate limiting step in amyloid beta(Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity relationship.Methods: A systematic study of 70% ethanolic P. lobata root extract was employed to identify its BACE1 inhibitory potential. Further, BACE1 inhibitory potential of two lupane terpenoids, yielded from ethanolic extract, was assessed. In order to determine their inhibition mode, Lineweaver–Burk plots and Michaelis–Menten model for BACE1 was performed. Auto Dock 4.2 program in addition determined the molecular interaction of BACE1 with isolated terpenoids.Results: Considering the inhibitory potential of 70% ethanolic extract of P. lobata against BACE1(IC_(50)= 80.35 mg/mL), lupeol and lupenone were subsequently isolated and exhibited notable or moderate BACE1 inhibitory activity with IC_(50) values of 5.12 and 62.98 mmol/L, respectively, as compared to the positive control quercetin(IC_(50)= 21.28 mmol/L). The enzyme kinetics study enabled us to identify both compounds as competitive inhibitors, where lupeol displayed a very potent inhibition against BACE1 with low inhibition constant(Ki) value of 1.43 mmol/L, signifying greater binding affinity.In order to understand the binding mechanism and structure–activity relationship of two triterpene-based BACE1 inhibitors, we employed computer aided docking studies which evidently revealed that hydroxyl group of lupeol formed two hydrogen bonds with the ASP32(catalytic aspartic residue) and SER35 residues of BACE1 with the binding energy of(-8.2 kcal/mol), while the ketone group of lupenone did not form any hydrogen bonds with BACE1 giving evidence for less binding affinity. These results in turn have predicted the dependence of the inhibitory activity in the presen

关键词： Pueraria lobata BACE1 Lupeol Lupenone Molecular docking Kinetics

关于“茶与人体健康:茶叶活性组分的生物医学效应和当前关注的若干问题”的讨论（英文）

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2015年第9期16卷 811-812页

作者： Sheng-rong SHEN Sovichea LAY department of food science & nutrition Zhejiang University

茶是世界上最受欢迎的饮料之一。人们享受消费,获得健康,普遍认为茶中生物活性物质可以使人体保持健康,免遭疾患。但当前的研究结果相互矛盾,要断定茶与人类健康的确切关系,证据不够充分,尤其是体外实验与临床结果的不一致,要明确阐述... 详细信息

茶是世界上最受欢迎的饮料之一。人们享受消费,获得健康,普遍认为茶中生物活性物质可以使人体保持健康,免遭疾患。但当前的研究结果相互矛盾,要断定茶与人类健康的确切关系,证据不够充分,尤其是体外实验与临床结果的不一致,要明确阐述茶与人体的健康关系为时尚早。因此,需要更多的研究手段、研究技术和流行病调查,跨越饮茶的传统方式,采用更先进的方法,如纳米技术等,以求确凿的科学证据。

关键词：茶健康活性组分

Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease

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food science and Human Wellness 2023年第3期12卷 889-894页

作者： Yanan Sun Ning Liu Huihui Wang Taiqi Qu Fazheng Ren Yixuan Li Key Laboratory of Precision nutrition and food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100193China College of food science and Engineering Gansu Agricultural UniversityLanzhou 730070China

Modern technological lifestyles promote allergic diseases,especially food allergies.The underlying molecular mechanisms remain to be uncovered.Protein acetylation is one of the most important post-translational modifications,and it is involved in regulating multiple body metabolic processes.This study aimed to clarify the effects of a high-fat diet(HFD)on allergy risk and the underlying mechanisms.Four-week-old male C57 BL/6 J mice were randomly divided into two groups and fed a normal fat diet(NFD)or HFD for 24 weeks.Then,serum lipids were measured,and skeletal muscle was collected for acetylome analysis.Compared with the findings in the NFD group,HFD-fed mice were obese and hyperlipidemic.Acetylome analysis also revealed 32 differentially expressed proteins between the HFD and NFD groups.Among these,eight acetylated proteins were upregulated in the HFD group.In addition,13 and 11 proteins were acetylated only in the HFD group and NFD group,respectively.These proteins were mainly involved in regulating energy metabolism and mitochondrial function.This study provides information regarding the underlying molecular mechanisms by which HFD promotes allergy.

关键词： Allergic disease High fat diet Skeletal muscle Acetylome

Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA IKEDA NOZOMI NAGASE AI TSUJI KURUMI TANIGUCHI YASUKO KITAGISHI SATORU MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal proliferation.For the purpose of proliferation,secretome might exert its effects via the paracrine signaling.Specific microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family proteins.The biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer cells.In addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological condition.Therefore,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative medicine.Here,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA