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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

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Biomedical and Environmental Sciences 2024年第9期37卷 993-1002页

作者： Qingjun Jia Meichun Zeng Qi Chen Hangzhou Center for disease control and prevention(Hangzhou Health Supervision Institution) Hangzhou 310021ZhejiangChina department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003ZhejiangChina

Objective This study aimed to investigate the prevalence of Epstein-Barr virus(EBV)infection in patients with and without *** A total of 26,648 participants who underwent whole-blood EBV DNA(WBEBV)assays between January 1,2020,and August 31,2023,were *** chi-square test was used for categorical data analysis,and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of *** Positive rates were 10.2%and 25.4%for healthy controls(HC)and patients,*** positivity rate for EBV-associated neoplasms(EN)was the highest at 7.53%,followed by leukemia(Le)at 5.49%.The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia(APH)was 31.9%,followed by 30.5%for *** WBEBV of patients with transplants(TP),especially living-related transplants(LT),was the highest among all *** at diagnosis was used to differentiate between infectious mononucleosis(IM)and chronic active Epstein-Barr virus(CAEBV),with a sensitivity of 67.4%(95%confidence interval[CI]:57.6-75.8)and specificity of 72%(95%CI:63.3-79.3).We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT,IM,and Lymphocyte Leukemia(LL).Conclusion This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases,including the stages and *** EBV detection rate was higher in patients with malignant disease than in those with benign *** study provides clinicians with baseline information regarding EBV-associated diseases.

关键词： Epstein-Barr virus Epstein-Barr virus DNA Whole blood Epstein-Barr virus DNA Viral load

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A Case of an 86-Year-Old Male Survivor with Human Respiratory Syncytial Virus and SARS-CoV-2 Virus Coinfection

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China CDC weekly 2024年第8期6卷 148-150,I0001,I0002页

作者： Lan Wang Jinren Pan Yajie Fu Haiyan Lou Yin Chen Yunmei Yang Shelan Liu department of Geriatrics First Affiliated HospitalZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina department of Infectious diseases Zhejiang Provincial Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina department of Laboratory Medicine First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina department of Radiology First Affiliated HospitalZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina department of Microbiology Zhejiang Provincial Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina

As coronavirus disease 2019(COVID-19)public health restrictions are relaxed,the circulation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)alongside other respiratory viruses may lead to an increased likelihood of coinfection(1).Older patients face a higher risk of severe outcomes,when infected with multiple respiratory viruses(2).This study highlights the successful recovery of the oldest older adult(≥80 years)from pneumonia caused by the dual infection of human respiratory syncytial virus(HRSV)and SARS-CoV-2.

关键词： respiratory acute vivo

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Epidemiological characteristics of tuberculosis incidence and its macro-influence factors in Chinese mainland during 2014-2021

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Infectious diseases of Poverty 2024年第3期13卷 43-57页

作者： Le-le Deng Fei Zhao Zhuo-wei Li Wei-wei Zhang Guang-xue He Xiang Ren National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China department of Pharmacy Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication EvaluationBeijing 100730China Miyun District Center for disease control and prevention Beijing 101500China School Of Public Health Binzhon Medical UniversityYantai 264000China Division of Infectious disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionBeijing 102206China

Background Tuberculosis(TB)remains a pressing public health issue,posing a significant threat to individuals'well-being and *** study delves into the TB incidence in Chinese mainland during 2014-2021,aiming to gain deeper insights into their epidemiological characteristics and explore macro-level factors to enhance control and *** TB incidence data in Chinese mainland from 2014 to 2021 were sourced from the National Notifiable disease Reporting System(NNDRS).A two-stage distributed lag nonlinear model(DLNM)was constructed to evaluate the lag and non-linearity of daily average temperature(℃,Atemp),average relative humidity(%,ARH),average wind speed(m/s,AWS),sunshine duration(h,SD)and precipitation(mm,PRE)on the TB incidence.A spatial panel data model was used to assess the impact of demographic,medical and health resource,and economic factors on TB *** A total of 6,587,439 TB cases were reported in Chinese mainland during 2014-2021,with an average annual incidence rate of 59.17/100,*** TB incidence decreased from 67.05/100,000 in 2014 to 46.40/100,000 in 2021,notably declining from 2018 to 2021(APC=-8.87%,95%CI:-11.97,-6.85%).TB incidence rates were higher among males,farmers,and individuals aged 65 years and *** analysis revealed a significant cluster in Xinjiang,Qinghai,and Xizang from March 2017 to June 2019(RR=3.94,P71.73%),low sunshine duration(<6.18 h)increased the risk of TB incidence,while extreme low wind speed(<2.79 m/s)decreased the *** spatial Durbin model showed positive associations between TB incidence rates and sex ratio(β=1.98),number of beds in medical and health institutions per 10

关键词： Tuberculosis Surveillance Epidemiological characteristics Incidence Influence factor Distributed lag nonlinear model(DLNM) Spatial panel model China

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Incidence,prevalence,and causes of spinal injuries in China,1990-2019:Findings from the Global Burden of disease Study 2019

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Chinese Medical Journal 2024年第6期137卷 704-710页

作者： Chenjun Liu Tingling Xu Weiwei Xia Shuai Xu Zhenqi Zhu Maigeng Zhou Haiying Liu department of Spinal Surgery Peking University People’s HospitalPeking UniversityBeijing 100044China Chinese Preventive Medicine Association Committee on Prevention and Control of Spinal DiseaseBeijing 100009China National Center for Chronic and Noncommunicable disease control and prevention Chinese Center for Disease Control and PreventionBeijing 100050China School of Public Health Xi’an Jiaotong UniversityXi’anShaanxi 710061China

Background:Spinal injuries are an urgent public health priority;nevertheless,no China-wide studies of these injuries *** study measured the incidence,prevalence,causes,regional distribution,and annual trends of spinal injuries in China from 1990 to ***:We used data from the Global Burden of diseases,Injuries,and Risk Factors Study 2019 to estimate the incidence and prevalence of spinal injuries in *** data of 33 provincial-level administrative regions(excluding Taiwan,China)provided by the National Center for Chronic and Noncommunicable disease control and prevention,Chinese Center for disease control and prevention(CDC)were use to systematically analyze the provincial etiology,geographical distribution,and annual trends of spinal *** Bayesian meta-regression tool DisMod-MR 2.1 was used to ensure the consistency among incidence,prevalence,and mortality rates in each ***:From 1990 to 2019,the number of living patients with spinal injuries in China increased by 138.32%,from 2.14 million to 5.10 million,while the corresponding age-standardized prevalence increased from 0.20%(95%uncertainty interval[UI]:0.18-0.21%)to 0.27%(95%UI:0.26-0.29%).The incidence of spinal injuries in China increased by 89.91%(95%UI:72.39-107.66%),and the prevalence increased by 98.20%(95%UI:89.56-106.82%),both the most significant increases among the G20 countries;71.00%of the increase could be explained by age-specific *** 2019,the incidence was 16.47(95%UI:12.08-22.00,per 100,000 population),and the prevalence was 358.30(95%UI:333.96-386.62,per 100,000 population).Based on the data of 33 provincial-level administrative regions provided by CDC,age-standardized incidence and prevalence were both highest in developed provinces in Eastern *** primary causes were falls and road injuries;however,the prevalence and specific causes differed across ***:In China,the overall disease burden of spinal injuries increased significantl

关键词： Spinal injuries Global Burden of diseases,Injuries and Risk Factors Study 2019 Incidence Prevalence Falls Road injuries

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Analysis of Trends of Cancer Epidemiology in Two Provinces of the Western and Eastern China

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Journal of Clinical and Nursing Research 2024年第4期8卷 213-218页

作者： Shimin Deng Xianbin Ding Xiaoyan Lu Zhifu Dong Hongdan Cao Wanzhen Tang department of Nursing Medicine Chongqing Medical and Pharmaceutical CollegeChongqing 401331China department of Chronic and Non-communicable disease prevention and control Chongqing Municipal Centre for Disease Prevention and ControlChongqing 400042China

In this paper, the literature on the incidence and death of malignant tumors in the Chongqing and Jiangsu provinces from 2014-2016 was collected through a literature review. The overall incidence, mortality, tumor spectrum, and possible risk factors of malignant tumor incidence and death in the Chongqing and Jiangsu provinces were compared and analyzed. This aims to provide references and suggestions for the prevention and control of malignant tumors in China.

关键词： Cancer Incidence Mortality

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Effective Nucleic Acid Contamination Disinfection in Laboratory Settings using Ozone Gas

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Biomedical and Environmental Sciences 2024年第9期37卷 1095-1100页

作者： Yingyi Long Linlin Liang Xingyan Zhou Fei Ren Lu Wang Peng Zhang Jing Wang department of Laboratory The Second People’s Hospital of Jiulongpo DistrictChongqing 400030China Jiulongpo District Center for disease control and prevention Chongqing 400030China

The Nucleic Acid Laboratory,a division of the Clinical Laboratory department,is responsible for performing real-time PCR(qPCR)assays to rapidly detect infectious diseases,genetic disorders,and more[1].As the gold standard,qPCR has played an indispensable role in diagnosing pandemic infections,such as the coronavirus disease 2019(COVID-19)[2].

关键词： qPCR indispensable performing

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Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Qing-Qing Pan Ming-Ke Wang Ji-Shun Yang department of disease control and prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

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Burden of digestive system diseases in China and its provinces during 1990-2019: Results of the 2019 Global disease Burden Study

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中华医学杂志(英文版) 2024年第18期137卷 2024 Aug 14页

作者： Cheng Zhiyuan Wang Tinglu Jiao Yunfei Qi Jinlei Zhang Xun Zhou Siwei Xin Lei Wan Rong Zhou Maigeng Li Zhaoshen Wang Luowei department of Gastroenterology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Digestive Endoscopy Center Department of Gastroenterology Changhai Hospital Naval Medical University Shanghai China National Gastroenterology Quality Improvement System Shanghai China National Center for Chronic and Non-Communicable disease control and prevention Chinese Center for Disease Control and Prevention Beijing China

Background: Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking. Our study aimed to provide an overview of the burden and trends of digestive system diseases from 1990 to 2019 in China and its ***: This cross-sectional study utilized the Global disease Burden Study 2019 to estimate the incidence, mortality rate, disability-adjusted life years (DALYs), years of life disability, years of life lost, and changes in the burden of digestive diseases across Chinese provinces from 1990 to 2019. The analysis of disease burden primarily examines the characteristics of sub-disease distribution, time trends, age distribution, and sex distribution. Additionally, we compared provincial age-standardized DALYs for digestive diseases with the expected rates based on the socio-demographic index (SDI).Results: In 2019, there were 499.2 million cases of digestive system diseases in China, resulting in 1,557,310 deaths. Stomach cancer, colon and rectal cancer, and esophageal cancer are the top three diseases associated with mortality and DALY related to digestive system diseases. Meanwhile, cirrhosis and other chronic liver diseases, gastroesophageal reflux disease, and gallbladder and biliary diseases are the top three kinds of diseases with the highest prevalence among digestive system diseases. The risk of gastric cancer sharply increases among men after the age of 40 years, leading to a significant disparity in burden between men and women. As the SDI increased, the DALYs associated with digestive system diseases in China and its provinces showed a downward ***: Our study highlights the inverse correlation between DALYs associated with digestive system diseases and the SDI.

关键词： Chronic liver diseases Colon and rectal cancer Digestive disease Epidemiology Esophageal cancer Gastrointestinal diseases Health expenditures Liver cancer Stomach cancer

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More common RNAemia in the early stage of severe SARS-CoV-2 BF.7.14 infections in pediatric patients

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Biosafety and Health 2024年第1期6卷 5-11页

作者： Yu Sun Runan Zhu Yang Pan Ri De Shuang Liu Liping Jia Bing Lv Xiaoyun Li Dongmei Chen Yao Yao Dong Qu Daitao Zhang Linqing Zhao Laboratory of Virology Bejing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBejing 100020China Institute for Infectious disease and endemic disease control Bejing Center for Disease Control and Prevention Beijing 100013China department of Intensive Care Unit Affiliated Children's Hospital of Capital Institute of PediatricsBeijing 100020China

The risk factors of severe infections in children during the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)outbreak in Beijing remain ***‐CoV‐2‐positive children admitted to the intensive care unit(ICU)with collected plasma specimens were enrolled and screened for common pathogens using capillary electrophoresis‐based multiplex PCR from December 12,2022,to January 24,*** SARS‐CoV‐2 subvariants were identified using next‐generation *** was positive for two(positive;P),one(suspicious;S),or no(negative;N)SARS‐CoV‐2 genes were classified as plasmatic RNA‐positive(RNAemia;P+S)or without RNAemia(N).Clinical and laboratory data of the enrolled cases were then collected and *** 34 enrolled children included 26 males and 24 younger than three *** were negative for other respiratory ***.7.14(18/29)was the predominant *** loads in respiratory specimens,hours from symptom onset to the first respiratory specimen collection(time‐variable),with comorbidities and BF.7.14 and BA.5.2 distributions were significantly different in P vs.N and RNAemia *** RNAemia *** most cases,the T lymphocyte ratios decreased,while the cytokine level and the B lymphocyte ratio *** time variables were 2.22±2.05 and 4.00±2.49 days in BF.7.14 and BA.5.2 infections,*** conclusion,SARS‐CoV‐2 was more likely to cause severe infections among males aged≤3 years old with comorbidities during the SARS‐CoV‐2 outbreak in Beijing,while RNAemia is more common in children at the early stage of severe BF.7.14 infections,and most had high cytokine levels and B‐cell activation.

关键词： Severe SARS‐CoV‐2 infection Pediatric patients Risk factor RNAemia BF.7.14

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