Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

作     者：LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao LI Yang;LIN Dan;ZHANG Xiu Qin;JU Guang Xiu;SU Ya;ZHANG Qian;DUAN Hai Ping;YU Wei Sen;WANG Bing Ling;PANG Shu Tao

作者机构：Department of Epidemiology and Health StatisticsSchool of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental HealthQingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical LaboratoryQingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health CareHuangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood CenterQingdao 266071ShandongChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2024年第37卷第5期

页      面：479-493页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100404[医学-儿少卫生与妇幼保健学] 10[医学] 

基　　金：partly supported by grants from the National Natural Science Foundation of China(No:81372955) BiosTime Maternal and Infant Nutrition and Health Research Fund(2017FYH008) the Projects of Medical and Health Technology Development Program in Shandong Province(No:2016WS0309) Qingdao Outstanding Health Professional Development Fund(2020-2022,2022-2024) 

主　　题：Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile 

摘      要：Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection1,P0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.