Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

作     者：Qingjun Jia Meichun Zeng Qi Chen Qingjun Jia;Meichun Zeng;Qi Chen

作者机构：Hangzhou Center for Disease Control and Prevention(Hangzhou Health Supervision Institution)Hangzhou 310021ZhejiangChina Department of PathologyThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003ZhejiangChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2024年第37卷第9期

页      面：993-1002页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：sponsored by Hangzhou Medical Health Science and Technology Project[No.A20220558] the Special Supporting Program of Agriculture and Social Development from Hangzhou Municipal Science&Technology Bureau[No.202203B34] 

主　　题：Epstein-Barr virus Epstein-Barr virus DNA Whole blood Epstein-Barr virus DNA Viral load 

摘      要：Objective This study aimed to investigate the prevalence of Epstein-Barr virus(EBV)infection in patients with and without *** A total of 26,648 participants who underwent whole-blood EBV DNA(WBEBV)assays between January 1,2020,and August 31,2023,were *** chi-square test was used for categorical data analysis,and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of *** Positive rates were 10.2%and 25.4%for healthy controls(HC)and patients,*** positivity rate for EBV-associated neoplasms(EN)was the highest at 7.53%,followed by leukemia(Le)at 5.49%.The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia(APH)was 31.9%,followed by 30.5%for *** WBEBV of patients with transplants(TP),especially living-related transplants(LT),was the highest among all *** at diagnosis was used to differentiate between infectious mononucleosis(IM)and chronic active Epstein-Barr virus(CAEBV),with a sensitivity of 67.4%(95%confidence interval[CI]:57.6-75.8)and specificity of 72%(95%CI:63.3-79.3).We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT,IM,and Lymphocyte Leukemia(LL).Conclusion This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases,including the stages and *** EBV detection rate was higher in patients with malignant disease than in those with benign *** study provides clinicians with baseline information regarding EBV-associated diseases.