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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK department of Basic and clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

The Nature of “Natural Disasters”: Survivors’ Explanations of Earthquake Damage

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International Journal of Disaster Risk Science 2019年第3期10卷 293-305页

作者： Alessandro Massazza Chris R.Brewin Helene Joffe department of clinical Educational and Health PsychologyUniversity College London

The distinction between natural and human-made disasters is ingrained in everyday language. Disaster scientists have long been critical of this dichotomy. Nonetheless,virtually no attention has been paid to how disaster survivors conceptualize the causes of the disasters they experience. In this mixed-methods longitudinal study, 112 survivors of the2016–2017 Central Italy earthquakes completed questionnaires 3 and 16 months following the earthquakes, with the aim of assessing attributions of blame for the earthquake damage. In-depth interviews were also conducted with 52 participants at the 3-month mark to explore representations of causation for the earthquake damage. The distinction between disasters caused by nature and disasters caused by humans was not supported by survivors of the earthquake. In the longitudinal surveys, building firms and the State were assigned as much blame as nature for the earthquake damage, at both 3 months and 16 months after the *** this complexity, in the interviews, the causes of the earthquake damage, rather than being understood as purely natural, were perceived as a complex mosaic composed of political, technological, natural, and moral *** empirical work shows that disaster survivors combine both nature-based and human-based explanations of disasters, rather than subscribing to one or the other. These findings have practical implications for disaster risk reduction and response.

关键词： Amatrice Attributions Disaster causes Disaster survivors Human-made disasters Natural disasters 2016–2017 Central Italy earthquakes

Local Volunteerism and Resilience Following Large-Scale Disaster: Outcomes for Health Support Team Volunteers in Haiti

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International Journal of Disaster Risk Science 2014年第3期5卷 206-213页

作者： Jessica A.Carlile Kira Mauseth NoёlE.Clark Jennifer L.Cruz John W.Thoburn department of clinical psychology Seattle Pacific UniversitySeattleWA 98119USA department of psychology Seattle UniversitySeattleWA 98122USA

In-depth interviews with local Haitian volunteers trained in a psychological disaster recovery program called Health Support Team(HST) provide insight into the psychosocial outcomes resulting from their engagement with the program. Qualitative interviews were conducted with four male Haitian participants who had survived the January 2010 Haiti earthquake and had worked as HST volunteers for at least 6 months. Interviews were analyzed using narrative inquiry analysis, which allows individuals to discover and disclose a deeper meaning in their experience and enables the researchers to access more detailed data. Previous research supports the claim that volunteerism provides many important psychological benefits, and the results of the present study suggest that among survivors of large-scale disasters, volunteerism is beneficial as a means of increasing psychological resilience and facilitating personal recovery. Results and themes of our analysis included a reported increase in both hope and purpose for the respondents. Findings suggest that volunteerism on the part of members of the surviving community following large-scale disaster increases resilience among the volunteers and further contributes to their recovery.

关键词： Haiti earthquake Large-scale disaster Post-disaster resilience Recovery process Volunteerism

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Thinking about worry:A systematic review and meta-analysis on the assessment of metacognitions in children and adolescents

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World Journal of Psychiatry 2021年第9期11卷 635-658页

作者： Laura M Kocher Kai Schneider Hanna Christiansen department of psychology University of MarburgMarburg 35037Germany department of clinical Child and Adolescent psychology University of LandauLandau 76829Germany

BACKGROUND The metacognitive model of generalized anxiety disorder identifies three forms of metacognition:Positive metacognitive beliefs about worry(POS),negative metacognitive beliefs about worry(NEG),and *** this model was originally developed relying on adult samples,it has since been applied to children and youth in different studies,and results mostly support its validity for this *** the roles of POS,meta-worry,and age-effects do not appear to be fully clarified for children and adolescents yet,an integration of studies on children and adolescents and the metacognitive model is both timely and *** To summarize the current research on relationships,age-effects,and measurements for POS,NEG,and meta-worry in childhood and *** We carried out a literature search in the electronic databases PsycINFO,PubMed,PSYNDEX,and ERIC in 2017 and updated in *** research in German or English language on metacognition was included with child and adolescent samples diagnosed with anxiety disorders or healthy controls if POS,NEG,or meta-worry were *** were included for meta-analysis if they reported correlations between these metacognitions and anxiety or *** rating for eligibility was done for 20.89% of full-texts with 90.32% *** of bias was assessed with the appraisal tool for cross-sectional studies and consensus rating of appraisal tool for cross-sectional studies for 20.83% of included studies attaining agreement of intraclass correlation=***,correlations between metacognitions,anxiety and worry were calculated with RevMan 5.4.1,assuming random-effects ***-regressions with mean age as the covariate were performed via the online tool MetaMar ***-ID:*** Overall,k=763 records and k=78 additional records were *** those,k=48 studies with 12839 participants were included and of those,k=24 studies were included for *** studie

关键词： Metacognition Anxiety Child Adolescent Measures Meta-analysis

Risk factors for antenatal depression: A review

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World Journal of Psychiatry 2021年第7期11卷 325-336页

作者： M Carmen Míguez M Belén Vázquez department of clinical psychology and Psychobiology Faculty of PsychologyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain

Depression is the most prevalent mental disorder in pregnancy, and yet it is lessstudied than postpartum depression despite the consequences it may have onboth the pregnant woman and her offspring. Therefore, it would be important toknow which risk factors may favour the appearance of antenatal depression inorder to carry out appropriate prevention interventions. The aim of the presentreview was to identify the main risk factors of antenatal depression. We searchedin databases PubMed and PsycINFO for articles published about the factorsassociated with antenatal depression from January 2010 through December *** literature review identified three main groups of antenatal depression riskfactors: sociodemographic, obstetric, and psychological. First, among thesociodemographic variables, the low level of studies and the economic incomeclearly stood out from the rest. Then, not having planned the pregnancy was themain obstetric variable, and finally, the main psychological risk factors werehaving a history of psychological disorders and/or depression as well aspresenting anxiety, stress, and/or low social support during pregnancy. Thisreview shows that the antenatal depression is affected by multiple factors. Mostcan be identified at the beginning of the pregnancy, and some are risk factorspotentially modifiable through appropriate interventions, such as psychologicalfactors. For this reason, it is important to carry out a good screening for depressionduring pregnancy and consequently, be able to prevent its appearance ortreat it if necessary.

关键词： Depression Antenatal Antenatal depression Pregnancy Risk factors Review

Non-pharmacological interventions for Parkinson’s disease mild cognitive impairment: future directions for research

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Neural Regeneration Research 2020年第9期15卷 1650-1651页

作者： Davide Maria Cammisuli Roberto Ceravolo Ubaldo Bonuccelli Neurology Clinic Department of Clinical and Experimental MedicineUniversity of PisaPisaItaly clinical psychology Psychophysiology and Clinical Neuropsychology LaboratoryDepartment of Medicine and SurgeryUniversity of ParmaParmaItaly

Parkinson’sdisease-mildcognitiveimpairment(PD-MCI)currently represents a valid diagnostic clinical entity with potential interest for therapeutic *** is present in approximately 25–30%of non-demented patients with PD(Weintraub et al.,2018).Several risk factors are associated with Parkinson’s disease dementia(PDD)occurrence,such asoldageatonset,longdiseaseduration,motorimpairment and MCI(Nicoletti et al.,2019).

关键词： impairment al. clinical

Activation of cerebral Ras-related C3 botulinum toxin substrate(Rac) 1 promotes post-ischemic stroke functional recovery in aged mice

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Neural Regeneration Research 2024年第4期19卷 881-886页

作者： Fan Bu Jia-Wei Min Md Abdur Razzaque Ahmad El Hamamy Anthony Patrizz Li Qi Akihiko Urayama Jun Li department of Neurology University of Texas Health Science Center department of Neurology&psychology The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine

Brain functional impairment after stroke is common;however,the molecular mechanisms of post-stroke recovery remain *** is well-recognized that age is the most important independent predictor of poor outcomes after stroke as older patients show poorer functional outcomes following *** evidence suggests that axonal regeneration and angiogenesis,the major forms of brain plasticity responsible for post-stroke recovery,diminished with advanced *** studies suggest that Ras-related C3 botulinum toxin substrate(Rac)1 enhances stroke recovery as activation of Rac1 improved behavior recovery in a young mice stroke ***,we investigated the role of Rac1 signaling in long-term functional recovery and brain plasticity in an aged(male,18 to 22 months old C57BL/6J)brain after ischemic *** found that as mice aged,Rac1 expression declined in the *** overexpression of Rac1,using lentivirus encoding Rac1 injected day 1 after ischemic stroke,promoted cognitive(assessed using novel object recognition test)and sensorimotor(assessed using adhesive removal tests)recovery on days 14–*** was accompanied by the increase of neurite and proliferative endothelial cells in the periinfarct zone assessed by *** a reverse approach,pharmacological inhibition of Rac1 by intraperitoneal injection of Rac1 inhibitor NSC23766 for 14 successive days after ischemic stroke worsened the outcome with the reduction of neurite and proliferative endothelial ***,Rac1 inhibition reduced the activation of p21-activated kinase 1,the protein level of brain-derived neurotrophic factor,and increased the protein level of glial fibrillary acidic protein in the ischemic brain on day 28 after *** work provided insight into the mechanisms behind the diminished plasticity after cerebral ischemia in aged brains and identified Rac1 as a potential therapeutic target for improving functional recovery in the older adults after stroke.

关键词： aging angiogenesis brain-derived neurotrophic factor(BDNF) cerebral ischemia cognitive recovery neurite Pak1 Rac1 sensorimotor recovery

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina department of psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Yu-Tao Loo and the development of neuropsychology in China

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Protein & Cell 2017年第7期8卷 473-476页

作者： Yanyan Qian Wei Chen Shengjun Wen School of psychology Nanjing Normal University Nanjing 210097 China department of psychology Shaoxing University Shaoxing 312000 China department of CognitiveNeurology Hertie Institute for Clinical Brain Research University of Tubingen 72076 Tubingen Germany

Yu-Tao Loo （1906-1985）（Fig. 1） was one of the Chinese neuropsychologists who acted as a pioneer of structure and functions studies of human cerebral cortex （Qian 2013） in China. Loo made great contributions in laying a solid foun- dation for neuroanatomy and physiological psychology in China. Meanwhile, his academic research broadened the horizons of this field. Besides, as a scientist, he wrote a series of popular-science articles and books to disseminate scientific knowledge. He was also a firm patriot and keen on political construction in China.

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