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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Polymer-based smart fibers and textiles for wearable electronics

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science China Technological sciences 2025年第1期 85-120页

作者： Sanming HU Li WANG Zaixian YUAN Kun CHEN Wei PENG Hai YIN Zhijun SHI Guang YANG School of biomedical Engineering and imaging Xianning Medical CollegeHubei University of Science and Technology College of Life science and Technology Huazhong University of Science and Technology Wuhan Branch of the National science Library Chinese Academy of Sciences

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly, lightweight, flexible, and comfortable. In addition, they are considered to have potential applications in health monitoring, energy management, and human-machine interaction systems. Polymers and polymer fibers,with excellent mechanical strength, wrinkle resistance, and heat resistance, are widely used to fabricate smart fibers and textiles. Herein, a comprehensive overview of polymer-based fibers and textiles is provided. First, we review the design principles of various polymer-based smart textiles, including textile-based sensors, energy capture and storage textiles, and computation and display textiles. Next, materials used for preparing polymer-based smart fibers, such as metals, carbon-based materials, and natural and synthetic polymers, particularly conductive polymers, are summarized. In addition, this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart textiles. Furthermore, the applications of smart textiles in personal health monitoring, thermal management, energy capture and storage, and computation and displays are discussed. Finally, the current challenges, limitations, and future trends of smart fibers and textiles are discussed.

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain sciences University of MacaoMacao Special Administrative RegionChina department of biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs

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Chinese Journal of Cancer Research 2016年第4期28卷 383-396页

作者： Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi Medical Faculty Trakia University Institute of Biophysics & biomedical Engineering Bulgarian Academy of Sciences department of Molecular imaging and Theranostics National Institute of Radiological SciencesNational Institute for Quantum and Radiological Science and Technology Medical Faculty Sofia University

Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS^independent pathways. We try to answer the question：＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.

关键词： Cancer reactive oxygen species chemotherapy ROS-independent apoptosis ROS-dependent apoptosis

Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.Robert Singh Gyanendra Prasad Joshi Woong Cho School of Computing Sastra Deemed to be UniversityThanjavur613401India department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Graphene nanopores toward DNA sequencing： a review of experimental aspects

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science China Chemistry 2017年第6期60卷 721-729页

作者： Wei Chen Guo-Chang Liu Jun Ouyang Meng-Juan Gao Bo Liu Yuan-Di Zhao Britton Chance Center for biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics and Molecular imaging Key Laboratory Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review mainly focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.

关键词： graphene nanopore DNA sequencing nanopore fabrication

Differentiation between dysplastic nodule and early-stage hepatocellular carcinoma: The utility of conventional MR imaging

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World Journal of Gastroenterology 2013年第42期19卷 7433-7439页

作者： Chen-Te Chou Jung-Mao Chou Ting-An Chang Shiu-Feng Huang Chia-Bang Chen Yao-Li Chen Ran-Chou Chen department of biomedical imaging and radiological science National Yang-Ming Medical University department of Radiology Chang-Hua Christian Hospital department of Pathology Taipei City Hospital Transplant Medicine and Surgery Research Centre Chang-Hua Christian Hospital department of Radiology Taipei City Hospital

AIM:To elucidate the variety of ways early-stage hepatocellular carcinoma(HCC)can appear on magnetic resonance(MR)imaging by analyzing T1-weighted,T2-weighted,and gadolinium-enhanced dynamic ***:Seventy-three patients with well-differentiated HCC(wHCC)or dysplastic nodules were retrospectively identified from medical records,and new histological sections were prepared and *** tumor nodules were categorized into three groups:dysplastic nodule(DN),wHCC compatible with Edmondson-Steiner grade I HCC(w1-HCC),and wHCC compatible with Edmondson-Steiner gradeⅡHCC(w2-HCC).The signal intensity on pre-contrast MR imaging and the enhancing pattern for each tumor were recorded and compared between the three tumor ***:Among the 73 patients,14 were diagnosed as having DN,40 were diagnosed as having w1-HCC,and 19 were diagnosed as having *** measurements on T2-weighted axial images(T2WI)were statistically significant between DNs and wHCC(P=0.006)and between DN and w1-HCC(P=0.02).The other imaging features revealed no significant differences between DN and wHCC or between DN and *** on both T1W out-phase imaging(P=0.007)and arterial enhancement on dynamic study(P=0.005)showed statistically significant differences between w1-HCC and *** other imaging features revealed no significant differences between w1-HCC and ***:In the follow-up for a cirrhotic nodule,increased signal intensity on T2WI may be a sign of malignant ***,a noted loss of hyperintensity on T1WI and the detection of arterial enhancement might indicate further progression of the histological grade.

关键词： Dysplastic nodule Hepatocellular carcinoma Histological grading Magnetic resonance imaging Well-differentiated hepatocellular carcinoma

Parallel variable-density spiral imaging using nonlocal total variation reconstruction

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Chinese Physics B 2014年第5期23卷 530-536页

作者：方晟郭华 Institute of Nulcear and New Energy Technology Tsinghua University Center for biomedical imaging Research Department of Biomedical EngineeringSchool of MedicineTsinghua University

The relatively long scan time is still a bottleneck for both clinical applications and research of magnetic resonance imaging. To reduce the data acquisition time, we propose a novel fast magnetic resonance imaging method based on parallel variable-density spiral acquisition, which combines undersampling optimization and nonlocal total variation reconstruction. The undersampling optimization promotes the incoherence of resultant aliasing artifact via the ＂worst-case＂ residual error metric, and thus accelerates the data acquisition. Moreover, nonlocal total variation reconstruction is utilized to remove such an incoherent aliasing artifact and so improve image quality. The feasibility of the proposed method is demonstrated by both numerical phantom simulation and in vivo experiment. The experimental results show that the proposed method can achieve high acceleration factor and effectively remove an aliasing artifact from data undersampling with well-preserved image details. The image quality is better than that achieved with the total variation method.

关键词： magnetic resonance imaging variable-density spiral parallel imaging nonlocal total variation

Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody

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World Journal of Gastroenterology 2018年第48期24卷 5491-5504页

作者： Winn Aung Atsushi B Tsuji Aya Sugyo Hiroki Takashima Masahiro Yasunaga Yasuhiro Matsumura Tatsuya Higashi department of Molecular imaging and Theranostics National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and Technology (QST-NIRS) Division of Developmental Therapeutics Exploratory Oncology Research and Clinical Trial CenterNational Cancer Center

AIM To investigate near-infrared photoimmunotherapeutic effect mediated by an anti-tissue factor(TF) antibody conjugated to indocyanine green(ICG) in a pancreatic cancer *** Near-infrared photoimmunotherapy(NIR-PIT) is a highly selective tumor treatment that utilizes an antibody-photosensitizer conjugate administration, followed by NIR light exposure. Anti-TF antibody 1849-ICG conjugate was synthesized by labeling of rat IgG2 b anti-TF monoclonal antibody 1849(anti-TF 1849) to a NIR photosensitizer,ICG. The expression levels of TF in two human pancreatic cancer cell lines were examined by western blotting. Specific binding of the 1849-ICG to TF-expressing BxPC-3 cells was examined by fluorescence microscopy. NIR-PITinduced cell death was determined by cell viability imaging assay. In vivo longitudinal fluorescence imaging was used to explore the accumulation of 1849-ICG conjugate in xenograft tumors. To examine the effect of NIRPIT, tumor-bearing mice were separated into 5 groups:(1) 100 μg of 1849-ICG i.v. administration followed by NIR light exposure(50 J/cm2) on two consecutive days(Days 1 and 2);(2) NIR light exposure(50 J/cm2) only on two consecutive days(Days 1 and 2);(3) 100 μg of 1849-ICG i.v. administration;(4) 100 μg of unlabeled antiTF 1849 i.v. administration; and(5) the untreated control. Semiweekly tumor volume measurements, accompanied with histological and immunohistochemical(IHC) analyses of tumors, were performed 3 d after the 2nd irradiation with NIR light to monitor the effect of treatments. RESULTS High TF expression in BxPC-3 cells was observed via western blot analysis, concordant with the observed preferential binding with intracellular localization of 1849-ICG via fluorescence microscopy. NIR-PIT-induced cell death was observed by performing cell viability imaging assay. In contrast to the other test groups, tumor growth was significantly inhibited by NIR-PIT with a statistically significant difference in relative tumor volumes for

关键词： Pancreatic cancer Anti-tissue factor antibody Indocyanine green Photoimmunotherapy Near-infrared