Graphene nanopores toward DNA sequencing： a review of experimental aspects

作     者：Wei Chen Guo-Chang Liu Jun Ouyang Meng-Juan Gao Bo Liu Yuan-Di Zhao 

作者机构：Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics and Molecular Imaging Key Laboratory Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2017年第60卷第6期

页      面：721-729页

核心收录：

学科分类：07[理学] 08[工学] 070205[理学-凝聚态物理] 09[农学] 071007[理学-遗传学] 090102[农学-作物遗传育种] 0710[理学-生物学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0901[农学-作物学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (81471697) the Key Technology R&D Program of Hubei Province (2014BBB003) Yellow Crane Talent (Science & Technology) Program of Wuhan City and Applied Basic Research Program of Wuhan City (2016060101010044, 2016060101010048) the Fundamental Research Funds for the Central Universities (2016YXMS253) 

主　　题：DNA测序 纳米孔 石墨 审查 验方 物质结构 高通量分析 测序技术 

摘      要：Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review mainly focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.