Differentiation between dysplastic nodule and early-stage hepatocellular carcinoma: The utility of conventional MR imaging

作     者：Chen-Te Chou Jung-Mao Chou Ting-An Chang Shiu-Feng Huang Chia-Bang Chen Yao-Li Chen Ran-Chou Chen 

作者机构：Department of Biomedical Imaging and Radiological ScienceNational Yang-Ming Medical University Department of RadiologyChang-Hua Christian Hospital Department of PathologyTaipei City Hospital Transplant Medicine and Surgery Research CentreChang-Hua Christian Hospital Department of RadiologyTaipei City Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第42期

页      面：7433-7439页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Dysplastic nodule Hepatocellular carcinoma Histological grading Magnetic resonance imaging Well-differentiated hepatocellular carcinoma 

摘      要：AIM:To elucidate the variety of ways early-stage hepatocellular carcinoma(HCC)can appear on magnetic resonance(MR)imaging by analyzing T1-weighted,T2-weighted,and gadolinium-enhanced dynamic ***:Seventy-three patients with well-differentiated HCC(wHCC)or dysplastic nodules were retrospectively identified from medical records,and new histological sections were prepared and *** tumor nodules were categorized into three groups:dysplastic nodule(DN),wHCC compatible with Edmondson-Steiner grade I HCC(w1-HCC),and wHCC compatible with Edmondson-Steiner gradeⅡHCC(w2-HCC).The signal intensity on pre-contrast MR imaging and the enhancing pattern for each tumor were recorded and compared between the three tumor ***:Among the 73 patients,14 were diagnosed as having DN,40 were diagnosed as having w1-HCC,and 19 were diagnosed as having *** measurements on T2-weighted axial images(T2WI)were statistically significant between DNs and wHCC(P=0.006)and between DN and w1-HCC(P=0.02).The other imaging features revealed no significant differences between DN and wHCC or between DN and *** on both T1W out-phase imaging(P=0.007)and arterial enhancement on dynamic study(P=0.005)showed statistically significant differences between w1-HCC and *** other imaging features revealed no significant differences between w1-HCC and ***:In the follow-up for a cirrhotic nodule,increased signal intensity on T2WI may be a sign of malignant ***,a noted loss of hyperintensity on T1WI and the detection of arterial enhancement might indicate further progression of the histological grade.