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Leukocyte-Specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

Research 2024年第2期2023卷 123-137页

作者： Di Xiang Lei Jiang Qiong Yuan Yang Yu Ruiming Liu Meiting Chen Zheng Kuai Wendy Zhang Fan Yang Tingting Wu Zhiyu He Zuhui Ke Wanzi Hong Pengcheng He Ning Tan Yeying Sun Zhen Shi Xuebiao Wei Jianfang Luo Xiaoqiu Tan Yuqing Huo Gangjian Qin Chunxiang Zhang department of Cardiology Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular ResearchThe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhouSichuan 646000China department of biomedical engineering School of Medicine The University of Alabama at BirminghamBirminghamAL 35233USA department of Cardiology.Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial Institute of Geriatric MedicineGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100China Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including *** non-coding RNAs(lncRNAs)are a group of protein expression regulators;however,the roles of monocyte-lncRNAs in macrophage differentiation and its related vascular diseases are still *** study aims to investigate whether the novel leukocyte-specific lncRNA Morrbid could regulate macrophage differentiation and *** identified that Morrbid was increased in monocytes and arterial walls from atherosclerotic mouse and from patients with *** cultured monocytes,Morrbid expression was markedly increased during monocyte to M0 macrophage differentiation with an additional increase during M0 macrophage-to-M1 macrophage *** differentiation stimuli-induced monocyte-macrophage differentiation and the macrophage activity were inhibited by Morrbid ***,overexpression of Morrbid alone was sufficient to elicit the monocyte-macrophage *** role of Morrbid in monocyte-macrophage differentiation was also identified in vivo in atherosclerotic mice and was verified in Morrbid knockout *** identified that PI3-kinase/Akt was involved in the up-regulation of Morrbid expression,whereas s100a10 was involved in Morrbid-mediated effect on macrophage *** provide a proof of concept of Morrbid in pathogenesis of monocyte/macrophage-related vascular disease,we applied an acute atherosclerosis model in *** results revealed that overexpression of Morrbid enhanced but monocyte/macrophage-specific Morrbid knockout inhibited the monocytes/macrophages recruitment and atherosclerotic lesion formation in *** results suggest that Morrbid is a novel biomarker and a modulator of monocyte-macrophage phenotypes,which is involved in atherogenesis.

关键词： inhibited Mor markedly

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Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail Tayfur Jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo Kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of medicine Belmont UniversityNashvilleTN 37212USA department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia department of Emergency medicine University of Health Sciences34668 IstanbulTurkey Monash university Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama engineering and Computer Science Baylor UniversityWacoTX 76798USA department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA alabama department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey department of Emergency medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

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High-level expression of recombinant IgG1 by CHO K1 platform

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Frontiers of Chemical Science and engineering 2015年第3期9卷 376-380页

作者： Ningning Xu Jianfa Ou Al-Karim (AI) Gilani Lufang Zhou Margaret Liu department of Chemical and Biological engineering The University of Alabama Tuscaloosa AL 35294 USA departments of medicine and biomedical engineering The University of Alabama at Birmingham Birmingham AL 35294 USA

The Chinese Hamster Ovary （CHO K1） cell was used to express a targeted anti-cancer monoclonal antibody by optimizing the platform of the construction of production cell line in this study. The adherent CHO K1 was first adapted to suspension culture in chemical defined medium. Then the glutamine synthetase （GS） vector was applied to construct a single plasmid to overexpress a monoclonal antibody IgG1. Post transfection, the produc- tion of cell pool was optimized by glutamine-free selection and amplification using various concentrations of methio- nine sulfoximine. The best cell pool ofCHO K1/IgG1 was used to screen the top single clone using the limiting dilution cloning. Finally, a high IgG1 production of 780 mg/L was obtained from a batch culture. This study demonstrated that the construction of high producing cell line, from gene to clone, could be completed within six month and the gene amplification improved protein production greatly.

关键词： Chinese hamster ovary (CHO) monoclonal antibody IgG1 amplification cell line development

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology department CinvestavMexico City 07360Mexico department of medicine University of FribourgFribourg CH-1700Switzerland Beijing engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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WIPER: Weighted in-Path Edge Ranking for biomolecular association networks

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Quantitative Biology 2019年第4期7卷 313-326页

作者： Zongliang Yue Thanh Nguyen Eric Zhang Jianyi Zhang Jake Y.Chen Informatics Institute School of MedicineUniversity of AlabamaBirminghamAL 35233USA department of biomedical engineering University of AlabamaBirminghamAL 35233USA department of Computer Science University of AlabamaBirminghamAL 35233USA

Background:In network biology researchers generate biomolecular networks with candidate genes or proteins experimentally-derived from high-throughput data and known biomolecular *** bioinformatics research focuses on characterizing candidate genes/proteins,or nodes,with network characteristics,e.g.,betweenness ***,there have been few research reports to characterize and prioritize biomolecular associations("edges"),which can represent gene regulatory events essential to biological ***:We developed Weighted In-Path Edge Ranking(WIPER),a new computational algorithm which can help evaluate all biomolecular interactions/associations("edges")in a network model and generate a rank order of every edge based on their in-path traversal scores and statistical significance test *** validate whether WIPER worked as we designed,we tested the algorithm on synthetic network ***:Our results showed WIPER can reliably discover both critical"well traversed in-path edges",which are statistically more traversed than normal edges,and"peripheral in-path edges",which are less traversed than normal *** with other simple measures such as betweenness centrality,WIPER provides better biological *** the case study of analyzing postanal pig hearts gene expression,WIPER highlighted new signaling pathways suggestive of cardiomyocyte regeneration and *** the case study of Alzheimer's disease genetic disorder association,WIPER reports SRC:APP,AR:APP,APP:FYN,and APP:NES edges(gene-gene associations)both statistically and biologically important from PubMed ***:We believe that WIPER will become an essential software tool to help biologists discover and validate essential signaling/regulatory events from high-throughput biology data in the context of biological ***:The free WIPER API is described at the website(***/wiper/).

关键词： networks network molecular

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Monoclonal antibody-based cancer therapies

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Chinese Journal of Chemical engineering 2021年第2期34卷 301-307页

作者： Yingnan Si Arin L.Melkonian Keegan C.Curry Yuanxin Xu Maranda Tidwell Mingming Liu Ahmed F.Zaky Xiaoguang(Margaret)Liu department of biomedical engineering University of Alabama at Birmingham(UAB)1825 University BlvdBirminghamAL 35294USA department of medicine UAB17202nd Ave S.BirminghamAL 35294USA Chinese medicine Hospital 98 Shengcheng StreetShouguang 262700China department of Anesthesiology and Perioperative medicine UAB62519th Street SouthBirminghamAL 35294USA

Targeted therapy has been widely demonstrated as an effective strategy to treat cancers,the leading cause of death in the *** minireview summarizes the technical platforms and methodologies utilized to develop and engineer therapeutic monoclonal antibodies and antibody-drug ***,the USA FDA approved monoclonal antibody(mAb)-based targeted therapies are *** the representative innovative chimeric,humanized and fully human anti-cancer antibodies and antibody-drug conjugates are ***,the past and predictive market trend of therapeutic antibodies is discussed.

关键词： Monoclonal antibody Antibody-drug conjugate Anti-cancer therapy Market

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COVID-19 and cardiovascular complications:updates of emergency medicine

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Emergency and Critical Care medicine 2023年第3期3卷 104-114页

作者： Jianli Zhao Yaoli Xie Zhijun Meng Caihong Liu Yalin Wu Fuje Zhao Xinliang Ma Theodore A.Christopher Bernard J.Lopeza Yajing Wang Emergency medicine department Thomas Jefferson UniversityPhiladelphiaPAUSA department of biomedical engineering University of Alabama at BirminghamALUSA

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and SARS-CoV-2 variants,has become a global pandemic resulting in significant morbidity and *** cases of COVID-19 are characterized by hypoxemia,hyperinflammation,cytokine storm in *** studies have reported an association between COVID-19 and cardiovascular disease(CVD).Patients with CVD tend to develop severe symptoms and mortality if contracted COVID-19 with further elevations of cardiac injury ***,COVID-19 itself can induce and promoted CVD development,including myocarditis,arrhythmia,acute coronary syndrome,cardiogenic shock,and venous *** the direct etiology of SARS-CoV-2–induced cardiac injury remains unknown and underinvestigated,it is suspected that it is related to myocarditis,cytokine-mediated injury,microvascular injury,and stress-related *** vaccinations having provided the most effective approach to reducing mortality overall,an adapted treatment paradigm and regular monitoring of cardiac injury biomarkers is critical for improving outcomes in vulnerable populations at risk for severe *** this review,we focus on the latest progress in clinic and research on the cardiovascular complications of COVID-19 and provide a perspective of treating cardiac complications deriving from COVID-19 in emergency medicine.

关键词： Cardiovascular disease COVID-19 Emergency medicine SARS-CoV-2

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Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes

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Bone Research 2014年第2期2卷 121-130页

作者： Fengjie Zhang Qiling He Wing Pui Tsang W Timothy Garvey Wai Yee Chan Chao Wan Ministry of Education Key Laboratory for Regenerative medicine School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong school of biomedical Sciences Core Laboratory Institute of Stem Cell Genomics and Translational Research Shenzhen Research Institute The Chinese University of Hong Kong departments of Microbiology and Pathology University of Alabama at Birmingham AL USA department of Nutrition Sciences University of Alabama at Birmingham AL USA

Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bones from wild-type mice increased chondrocyte proliferation. Mice lacking insulin receptor （IR） selectively in chondrocytes （CartIR-/-） had no discernable differences in total femoral length compared to control littermates. However, CartIR-/- mice exhibited an increase in chondrocyte numbers in the growth plate than that of the controls. Chondrocytes lacking IR had elevated insulin-like growth factor （IGF）-IR mRNA and protein levels. Subsequently, IGF-1 induced phosphorylafion of Akt and ERK was enhanced, while this action was eliminated when the cells were treated with IGF-1R inhibitor Picropodophyllin. Deletion of the IR impaired chondrogenic differentiation, and the effect could not be restored by treatment of insulin, but partially rescued by IGF-1 treatment. Intriguingly, the size of hypertrophic chondrocytes was smaller in CartIR-/- mice when compared with that of the control littermates, which was associated with upregnlation of tuberous sclerosis complex 2 （TSC2）. These results suggest that deletion of the IR in chondrocytes sensitizes IGF-1R signaling and action, IR and IGF-1R coordinate to regulate the proliferation, differentiation and hypertrophy of growth plate chondrocytes.

关键词： IGF-1 independent actions in growth plate chondrocytes Insulin exerts direct

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Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP,TGFβ,and Wnt signaling in articular cartilage formation and osteoarthritis

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Bone Research 2022年第4期10卷 882-892页

作者： Yan Zhang Tao Zuo Abigail McVicar Hui-Lin Yang Yi-Ping Li Wei Chen department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Key Laboratory of biomedical Information engineering of Ministry of Education Biomedical Informatics and Genomics CenterSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049 ShaanxiP.R.China department of Orthopaedics the First Affiliated Hospital of Soochow UniversityOrthopaedic Institute of Soochow University899 Pinghai RoadSuzhou 215031 JiangsuP.R.China Division in Cellular and Molecular medicine Department of Pathology and Laboratory MedicineTulane University School of MedicineTulane UniversityNew OrleansLA 70112USA

Runt-related transcription factor 1(Runx1)plays a key role in cartilage formation,but its function in articular cartilage formation is *** generated non-inducible and inducible Runx1-deficient mice(Runx1^(f/f)Col2α1-Cre and Runx1^(f/f)Col2α1-CreER mice)and found that chondrocyte-specific Runx1-deficient mice developed a spontaneous osteoarthritis(OA)-like phenotype and showed exacerbated articular cartilage destruction under OA,characterized by articular cartilage degradation and cartilage ossification,with decreased Col2α1 expression and increased Mmp13 and Adamts5 ***-sequencing analysis of hip articular cartilage from the Runx1^(f/f)Col2α1-Cre mice compared to that from wild-type mice and subsequent validation analyses demonstrated that Runx1 is a central regulator in multiple signaling pathways,converging signals of the Hippo/Yap,TGFβ/Smad,and Wnt/β-catenin pathways into a complex network to regulate the expression of downstream genes,thereby controlling a series of osteoarthritic pathological ***-sequencing analysis of mutant knee joints showed that Runx1’s role in signaling pathways in articular cartilage is different from that in whole knee joints,indicating that Runx1 regulation is *** analysis confirmed that Runx1 deficiency decreased the levels of YAP and p-Smad2/3 and increased the levels of activeβ-*** of Runx1 dramatically increased YAP expression in ***-associated virus-mediated Runx1 overexpression in the knee joints of osteoarthritic mice showed the protective effect of Runx1 on articular cartilage damaged in *** results notably showed that Runx1 is a central regulator of articular cartilage homeostasis by orchestrating the YAP,TGFβ,and Wnt signaling pathways in the formation of articular cartilage and OA,and targeting Runx1 and its downstream genes may facilitate the design of novel therapeutic approaches for OA.

关键词： cartilage homeostasis protective

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引用

World Journal of Diabetes 2013年第4期4卷 145-150页

作者： Krista Casazza Lynae J Hanks Gregory A Clines Hubert M Tse Alan W Eberhardt department of Nutrition Sciences University of Alabama at Birmingham department of medicine University of Alabama at Birmingham department of Microbiology University of Alabama at Birmingham department of biomedical engineering University of Alabama at Birmingham

AIM: To evaluate properties of bone quantity/quality using young non-obese Type 1(T1D)-diabetic(NOD) prone and syngenic non-diabetic(***) ***: Quantitative bone assessment of tibia was conducted using dual-energy X-ray absorptiometry(DXA) for the evaluation of body mass,bone mineral content,body fat mass and lean *** assessment was accomplished by three-point breakage for assessment of force to failure and micro-computed tomography for evaluation of trabecular and cortical properties of *** addition,fasting blood was evaluated prior to sacrifice at week eleven and fifteen to evaluate and compare glucose homeostasis between the strains of ***: Our findings support a perturbation in the relationship between bone quantity,quality,and subsequently,the association between structure and *** were no differences in DXA-assessed body composition(body fat,% fat mass and lean mass) and bone composition(bone mineral content and bone mineral density) between ***,relative to ***,NOD mice had lower trabecular bone volume,relative trabecular bone volume,trabecular number and trabecular total material density(P < 0.05).Conversely,NOD mice had greater cortical total mean volume(P < 0.05).General linear models analysis adjusted for body weight revealed a significant contribution of T1D to bone health as early as 5 ***: It is well-established that diabetes is a significant risk factor for increased fractures,although the underlying mechanisms are not fully *** of bone parameters encompassing strength and structure early in the life course will facilitate the elucidation of the pathogenesis of impaired bone integrity.

关键词： Diabetes Bone strength Skeletal integrity Development and growth Non-obese diabetic

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