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Obstructive Tumor of the Palate in the Old Person: A Case Report

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Open Journal of Stomatology 2024年第5期14卷 199-205页

作者： Silly Toure Mouhamadou Makhtar Ndiaye Abibou Ndiaye Mamadou Coume Mame Sanou Diouf Baye Karim Diallo Maxillofacial surgery and Stomatology department Aristide Le Dantec University Hospital of Dakar Dakar Senegal Geriatrics department Aristide Le Dantec University Hospital of Dakar Dakar Senegal ENT and head and neck surgery department FANN University Hospital of Dakar Dakar Senegal

Introduction: Pleomorphic adenoma or mixed salivary gland tumor is a heterogeneous benign tumor of the salivary glands. The most common site is the parotid gland. Its extra-parotid locations, particularly in the accessory salivary glands, are rarer. We report a case of a pleomorphic adenoma of the posterior palate which posed management problems. Observation: This is an 85-year-old patient who consulted for a tumor of the posterior palate that had been evolving for 3 years. The examination revealed a globular tumor of the posterior palate extending beyond the midline by approximately 7 cm in long axis, shooting towards the oropharynx and hindering breathing, speech and eating, indicating a life-saving tracheotomy. A CT scan of the facial area revealed a well-circumscribed tumor at the expense of the soft palate, with multiple sites of bone lysis. The biopsy performed was in favor of a pleomorphic adenoma. The patient underwent total surgical excision of a huge tumor on the palate. The aftermath of the operation was marked by a loosening of the sutures with an oronasal fistula requiring the creation of an obturator plate due to the patient’s refusal to have another operation. Conclusion: Large pleomorphic adenoma of the posterior palate is a rare entity that can cause respiratory problems and surgical difficulties. His prognosis is generally good.

关键词： Pleomorphic Adenoma Posterior Palate Respiratory Disorders Prognosis Obturator Plaque

Analysis of the Influence of Sound Source Position and Electrode Placement on the Stimulation Pattern of the Cochlear Implant under Noise Conditions: Optimization of Auditory Perceptual Effects

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International Journal of Otolaryngology and head & neck surgery 2024年第3期13卷 194-212页

作者： Johannes Burkart School of Advanced Education Research and Accreditation Castell&#243n de la Plana Spain department of Otorhinolaryngology Head and Neck Surgery University Hospital Mannheim Mannheim Germany

Background: Cochlear implants (CI) are widely used to restore hearing in people with severe to profound hearing loss. However, optimizing CI performance, especially in difficult listening environments with background noise, remains a major challenge. Understanding the influence of factors such as sound source position and electrode placement on CI stimulation patterns is critical to improving auditory perception. Methods: In this study, an analysis was conducted to investigate the influence of sound source position and electrode placement on CI stimulation patterns under noisy conditions. For this purpose, a special measurement setup with a CI speech processor-microphone test box was used to simulate realistic listening scenarios and measure CI performance. Results: The results show that the effectiveness of CI noise reduction systems is influenced by factors such as the position of the sound source and electrode placement. In particular, the beamforming ultra zoom mode showed significantly better noise reduction than the omnidirectional mode, especially under real listening conditions. Furthermore, differences in electrode responses indicate individual variability in the CI user experience, highlighting the importance of personalized fitting algorithms. Conclusions: The results demonstrate the importance of considering environmental factors and individual differences when optimizing CI performance. Future research efforts should focus on the development of personalized fitting algorithms and the exploration of innovative strategies, such as the integration of artificial intelligence, to improve CI functionality in different listening environments. This study contributes to our understanding of CI stimulation patterns and lays the foundation for improving auditory perception in CI users.

关键词： Cochlear Implants Noise Reduction Ultra Zoom Beamforming Anatomical Variations Personalized Fittings

An intelligent prediction model of epidemic characters based on multi-feature

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 595-607页

作者： Xiaoying Wang Chunmei Li Yilei Wang Lin Yin Qilin Zhou Rui Zheng Qingwu Wu Yuqi Zhou Min Dai Information Center Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina School of Computer Science Qufu Normal UniversityRizhaoChina department of Allergy Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhou China 4department of Otorhinolaryngology‐head and neck surgery Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina department of Pulmonary and Critical Care Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina department of Traditional Chinese Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina

The epidemic characters of Omicron(***-scale transmission)are significantly different from the initial variants of *** data generated by large-scale transmission is important to predict the trend of epidemic ***,the re-sults of current prediction models are inaccurate since they are not closely combined with the actual situation of Omicron *** consequence,these inaccurate results have negative impacts on the process of the manufacturing and the service industry,for example,the production of masks and the recovery of the tourism *** authors have studied the epidemic characters in two ways,that is,investigation and ***,a large amount of data is collected by utilising the Baidu index and conduct questionnaire survey concerning epidemic ***,theβ-SEIDR model is established,where the population is classified as Susceptible,Exposed,Infected,Dead andβ-Recovered persons,to intelligently predict the epidemic characters of *** thatβ-Recovered persons denote that the Recovered persons may become Sus-ceptible persons with probabilityβ.The simulation results show that the model can accurately predict the epidemic characters.

关键词： artificial intelligence big data data analysis evaluation feature extraction intelligent information processing medical applications

Clinical risk factors for preterm birth and evaluating maternal psychology in the postpartum period

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World Journal of Psychiatry 2024年第5期14卷 661-669页

作者： Jia-Jun Chen Xue-Jin Chen Qiu-Min She Jie-Xi Li Qiu-Hong Luo department of Clinical Laboratory Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina department of Otolaryngology head and neck surgery Outpatient Shenzhen Children’s HospitalShenzhen 518000Guangdong ProvinceChina department of Prevention and Health Care Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina department of Obstetrics Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Although the specific pathogenesis of preterm birth(PTB)has not been thoroughly clarified,it is known to be related to various factors,such as pregnancy complications,maternal socioeconomic factors,lifestyle habits,reproductive history,environmental and psychological factors,prenatal care,and nutritional *** has serious implications for newborns and families and is associated with high mortality and ***,the prediction of PTB risk can facilitate early intervention and reduce its resultant adverse *** To analyze the risk factors for PTB to establish a PTB risk prediction model and to assess postpartum anxiety and depression in *** A retrospective analysis of 648 consecutive parturients who delivered at Shenzhen Bao’an District Songgang People’s Hospital between January 2019 and January 2022 was *** to the diagnostic criteria for premature infants,the parturients were divided into a PTB group(n=60)and a full-term(FT)group(n=588).Puerperae were assessed by the Self-rating Anxiety Scale(SAS)and Self rating Depression Scale(SDS),based on which the mothers with anxiety and depression symptoms were screened for further *** factors affecting PTB were analyzed by univariate analysis,and the related risk factors were identified by logistic *** According to univariate analysis,the PTB group was older than the FT group,with a smaller weight change and greater proportions of women who underwent artificial insemination and had gestational diabetes mellitus(P0.05).In addition,greater proportions of women with reproductive tract infections and greater white blood cell(WBC)counts(P0.05),shorter cervical lengths in the second trimester and lower neutrophil percentages(P0.001)were detected in the PTB group than in the FT *** PTB group exhibited higher postpartum SAS and SDS scores than did the FT group(P0.0001),with a higher number of mothers experiencing anxiety and depress

关键词： Preterm birth Risk factors Postpartum psychological state Risk model Prediction

Ionically Imprinting-Based Copper(Ⅱ)Label-Free Detection for Preventing Hearing Loss

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Engineering 2024年第2期33卷 276-282页

作者： Huan Wang Hui Zhang Xiaoli Zhang Hong Chen Ling Lu Renjie Chai The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033China State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda Hospital&Advanced Institute for Life and HealthSoutheast UniversityNanjing 210096China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical EngineeringShenzhen UniversityShenzhen 518060China department of Otolaryngology head and neck surgery Jiangsu Provincial Key Medical DisciplineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China department of Otolaryngology head and neck surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Copper is a microelement with important physiological functions in the ***,the excess copper ion(Cu^(2+))may cause severe health problems,such as hair cell apoptosis and the resultant hearing ***,the assay of Cu^(2+)is *** integrate ionic imprinting technology(IIT)and structurally colored hydrogel beads to prepare chitosan-based ionically imprinted hydrogel beads(IIHBs)as a low-cost and high-specificity platform for Cu^(2+)*** IIHBs have a macroporous microstructure,uniform size,vivid structural color,and magnetic *** incubated in solution,IIHBs recognize Cu^(2+)and exhibit a reflective peak change,thereby achieving label-free *** addition,benefiting from the IIT,the IIHBs display good specificity and selectivity and have an imprinting factor of 19.14 at 100μmol·L^(-1).These features indicated that the developed IIHBs are promising candidates for Cu^(2+)detection,particularly for the prevention of hearing loss.

关键词： Structural color Microfluidics Ionic imprinting Label-free detection Hearing loss

考虑各向异性变形的人耳鼓膜纤维增强细观本构模型

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Acta Mechanica Sinica 2024年第5期40卷 184-197页

作者：向书毅杜智博施汇斌严子铭孙永涛王杰柳占立 School of Aerospace Engineering Tsinghua University Beijing China department of Mechanics and Tianjin Key Lab of Nonlinear Dynamics and Control Tianjin University Tianjin China department of Otorhinolaryngology head and neck surgery Beijing Tongren Hospital Capital Medical University Beijing China Beijing Engineering Research Center of Audiological Technology Beijing China

鼓膜是听觉系统的重要组成部分,位于外耳道末端,是一种含胶原的多层软组织膜。鼓膜的纤维沿着径向和环向方向高度取向,其独特而复杂的超微结构使得力学行为呈现各向异性非线性,这对于声音传输很重要.然而,同时包含这两个特征的鼓膜本构... 详细信息

鼓膜是听觉系统的重要组成部分,位于外耳道末端,是一种含胶原的多层软组织膜。鼓膜的纤维沿着径向和环向方向高度取向,其独特而复杂的超微结构使得力学行为呈现各向异性非线性,这对于声音传输很重要.然而,同时包含这两个特征的鼓膜本构模型尚未提出.在本研究中,我们建立了考虑鼓膜纤维分布的细观本构模型,模型能够同时捕捉各向异性和非线性弹性力学行为.鼓膜被认为是包含两族胶原纤维的连续纤维增强复合材料,并通过整合沿厚度方向异质材料性质建立整体力学性质.均匀化的力学性质被假定沿着厚度方向均匀分布,并由径向胶原纤维,环向胶原纤维和等效各向同性基质的三个非耦合弹性贡献叠加组成.通过逆方法并使用文献数据校准模型.仿真结果表明,特定的胶原纤维排列是鼓膜条带试样变形呈现显著空间非均匀性及各向异性的原因。通过与纤维变形相关的强度准则,可以捕获在实验中观察到的鼓膜条带各向异性局部化失效模式。胶原纤维束的旋转和非线性性质是单轴加载下鼓膜条带非线性力学行为的起源.该细观本构模型为鼓膜的各向异性和非线性弹性力学行为提供了不同的视角.这项研究提高了我们对鼓膜力学行为的理解,并有助于仿生移植物的发展.

关键词：非线性弹性力学胶原纤维细观本构模型移植物空间非均匀性非线性性质听觉系统非线性力学行为

Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy

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Genes & Diseases 2024年第4期11卷 61-64页

作者： Xue Gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang Jinyuan Yang Yijin Chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang Yongyi Yuan Pu Dai College of Otolaryngology head and neck surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic Diseases State Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China Beijing Key Lab of Hearing Impairment Prevention and Treatment Chinese PLA Medical SchoolBeijing 100853China department of Otolaryngology PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关键词： auditory maintain potential

m^(6)A modification of lncRNA in middle ear cholesteatoma

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中南大学学报（医学版） 2024年第5期49卷 667-678页

作者： HE Jun XIE Shumin JIN Li FU Jinfeng YUAN Qiulin LIU Wei department of Otolaryngology-head and neck surgery Second Xiangya HospitalCentral South UniversityChangsha 410011 Clinical Medical Research Center for Otology in Hunan Province Changsha 410011 department of Otolaryngology-head and neck surgery Xiangya HospitalCentral South UniversityChangsha 410008 Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha 410008 Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha 410008 National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangsha 410008China

Objective:Middle ear cholesteatoma is a non-tumorous condition that typically leads to hearing loss,bone destruction,and other severe *** surgery being the primary treatment,the recurrence rate remains ***,exploring the molecular mechanisms underlying cholesteatoma is crucial for discovering new therapeutic *** study aims to explore the involvement of N6-methyladenosine(m^(6)A)methylation in long non-coding RNAs(lncRNAs)in the biological functions and related pathways of middle ear ***:The m^(6)A modification patterns of lncRNA in middle ear cholesteatoma tissues(n=5)and normal post-auricular skin tissues(n=5)were analyzed using an lncRNA m^(6)A transcriptome *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were conducted to identify potential biological functions and signaling pathways involved in the pathogenesis of middle ear *** RNA immunoprecipitation(MeRIP)-PCR was used to validate the m^(6)A modifications in cholesteatoma and normal skin ***:Compared with normal skin tissues,1525 lncRNAs were differentially methylated in middle ear cholesteatoma tissues,with 1048 showing hypermethylation and 477 showing hypomethylation[fold change(FC)≥3 or<1/3,P<0.05].GO enrichment analysis indicated that hypermethylated lncRNAs were involved in protein phosphatase inhibitor activity,neuron-neuron synapse,and regulation ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)receptor *** lncRNAs were associated with mRNA methyltransferase activity,secretory granule membrane,and mRNA *** analysis revealed that hypermethylated lncRNAs were mainly associated with 5 pathways:the Hedgehog signaling pathway,viral protein interaction with cytokines and cytokine receptors,mitogen-activated protein kinase(MAPK)signaling pathway,cytokine-cytokine receptor interaction,and adrenergic signaling in ***

关键词： long non-coding RNA m6A modifications middle ear cholesteatoma

Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-head and neck surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna department of surgery Londrina State UniversityLondrinaBrazil department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil department of Otorhinolaryngology University of São PauloSao PauloBrazil department of Otorhinolaryngology:head and neck surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss