Ionically Imprinting-Based Copper(Ⅱ)Label-Free Detection for Preventing Hearing Loss

作     者：Huan Wang Hui Zhang Xiaoli Zhang Hong Chen Ling Lu Renjie Chai Huan Wang;Hui Zhang;Xiaoli Zhang;Hong Chen;Ling Lu;Renjie Chai

作者机构：The Eighth Affiliated HospitalSun Yat-Sen UniversityShenzhen 518033China State Key Laboratory of Digital Medical EngineeringDepartment of Otolaryngology Head and Neck SurgeryZhongda Hospital&Advanced Institute for Life and HealthSoutheast UniversityNanjing 210096China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingDepartment of Biomedical EngineeringShenzhen UniversityShenzhen 518060China Department of Otolaryngology Head and Neck SurgeryJiangsu Provincial Key Medical DisciplineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Co-Innovation Center of NeuroregenerationNantong UniversityNantong 226001China Department of Otolaryngology Head and Neck SurgerySichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Institute for Stem Cell and RegenerationChinese Academy of ScienceBeijing 100101China Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2024年第33卷第2期

页      面：276-282页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by grants from the National Key Research and Development Program of China(2021YFA1101300,2021YFA1101800,and 2020YFA0112503) the National Natural Science Foundation of China(82030029,81970882,92149304,and 22302231) the Science and Technology Department of Sichuan Province(2021YFS0371) the Guangdong Basic and Applied Basic Research Foundation(2023A1515011986) the Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022,JCYJ20190813152616459,and JCYJ20190808120405672) the Futian Healthcare Research Project(FTWS2022013 and FTWS2023080) the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2104) the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(23qnpy153) 

主　　题：Structural color Microfluidics Ionic imprinting Label-free detection Hearing loss 

摘      要：Copper is a microelement with important physiological functions in the ***,the excess copper ion(Cu^(2+))may cause severe health problems,such as hair cell apoptosis and the resultant hearing ***,the assay of Cu^(2+)is *** integrate ionic imprinting technology(IIT)and structurally colored hydrogel beads to prepare chitosan-based ionically imprinted hydrogel beads(IIHBs)as a low-cost and high-specificity platform for Cu^(2+)*** IIHBs have a macroporous microstructure,uniform size,vivid structural color,and magnetic *** incubated in solution,IIHBs recognize Cu^(2+)and exhibit a reflective peak change,thereby achieving label-free *** addition,benefiting from the IIT,the IIHBs display good specificity and selectivity and have an imprinting factor of 19.14 at 100μmol·L^(-1).These features indicated that the developed IIHBs are promising candidates for Cu^(2+)detection,particularly for the prevention of hearing loss.