Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy

作     者：Xue Gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang Jinyuan Yang Yijin Chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang Yongyi Yuan Pu Dai Xue Gao;Weiqian Wang;Jincao Xu;Shasha Huang;Kun Yang;Jinyuan Yang;Yijin Chen;Guojian Wang;Mingyu Han;Zhendong Wang;Dongyang Kang;Yongyi Yuan;Pu Dai

作者机构：College of Otolaryngology Head and Neck SurgeryChinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic DiseasesState Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China Beijing Key Lab of Hearing Impairment Prevention and TreatmentChinese PLA Medical SchoolBeijing 100853China Department of OtolaryngologyPLA Rocket Force Characteristic Medical CenterBeijing 100088China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第4期

页      面：61-64页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.82171158,82271177,82271185,82171155) the National Key Research and Development,Project of China(No.2020YFC2008500) 

主　　题：auditory maintain potential 

摘      要：Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.