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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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The effect of enzymes on release of trace elements in feedstuffs based on in vitro digestion model for monogastric livestock

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Journal of animal science and Biotechnology 2019年第1期10卷 231-238页

作者： Xiaonan Yu Jianan Han Haiyun Li Yiwei Zhang Jie Feng Key Laboratory of animal nutrition & feed science College of Animal ScienceZhejiang University

Background: This experiment was conducted to study the effect of different feed enzymes(phytase,xylanase,β-glucanase) on release rate of trace elements(Fe,Cu,Mn and Zn) in 6 commonly used feedstuffs(corn,wheat,barley,soybean meal,wheat bran,wheat middlings) by using an in vitro model,simulating the digestive processes in stomach for 2 h and then in small intestine for 6 h at 39 °***: Phytase raised(P feedstuffs was increased after xylanase *** with the control group,the release rate of soluble Cu in corn,wheat,barley and soybean meal,soluble Zn in corn,wheat and wheat middlings and soluble of Mn in corn,wheat,barley and wheat bran increased(P feedstuff,after corresponding enzyme treatment,the contents of phytic acid,xylan and β-glucan were significantly lower than those of the control group(P feedstuffs can be released by feed *** may be necessary to take the trace elements in feedstuffs into account in the actual feed preparation including feed enzymes.

关键词： feedstuffs feed enzymes In vitro model Release rate Trace elements

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Melatonin promotes the development of the secondary hair follicles by regulating circMPP5

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Journal of animal science and Biotechnology 2023年第4期14卷 1696-1712页

作者： Xiaogao Diao Lingyun Yao Tao Duan Jiaxin Qin Liwen He Wei Zhang department of animal nutrition and feed science State Key Laboratory of Animal NutritionCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background The quality and yield of cashmere fibre are closely related to the differentiation and development of secondary hair follicles in the skin of cashmere *** higher the density of secondary hair follicles,the higher the quality and yield of cashmere from the *** of secondary hair follicles commences in the embryonic stage of life and is completed 6 months after *** experimental results from our laboratory showed that melatonin(MT)treatment of goat kids after their birth could increase the density of secondary hair follicles and,thus,improve the subsequent yield and quality of *** changes in the secondary hair follicles resulted from increases in levels of antioxidant and expression of anti-apoptotic protein,and from a reduction in *** present study was conducted to explore the molecular mechanism of MT-induced secondary hair follicle differentiation and development by using whole-genome *** MT had no adverse effect on the growth performance of cashmere kids but significantly improved the character of the secondary hair follicles and the quality of cashmere,and this dominant effect continued to the second *** promotes the proliferation of secondary hair follicle cells at an early *** formation of secondary hair follicles in the MT group was earlier than that in the control group in the second *** genome-wide data results involved KEGG analysis of 1044 DEmRNAs,91 DElncRNAs,1054 DEcircRNAs,and 61 DEmiRNAs which revealed that the mitogen-activated protein kinase(MAPK)signaling pathway is involved in the development of secondary hair follicles,with key genes(FGF2,FGF21,FGFR3,MAPK3(ERK1))being up-regulated and *** also found that the circMPP5 could sponged miR-211 and regulate the expression of *** We conclude that MT achieves its effects by regulating the MAPK pathway through the circMPP5 sponged the miR-211,regulating the expression of MAPK3,to induce

关键词： Cashmere MAPK Melatonin miR-211 Secondary hair follicle

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Restricted feeding regimens improve white striping associated muscular defects in broiler chickens

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animal nutrition 2023年第1期12卷 128-137页

作者： Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao Yuming Guo Bingkun Zhang Bo Wang State Key Laboratory of animal nutrition Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China

The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast *** the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 *** angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(P0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of ***,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P<0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P<0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P<0.05).In conclusion,IF starting in the first week decreases SC *** to AL,IF or fasting promotes muscular angiogenesis,increases SC number

关键词： Broiler chickens Intermittent feeding Angiogenesis Satellite cells White striping

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L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver

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animal nutrition 2018年第3期4卷 329-338页

作者： Tongxin Wang Weilei Yao Qiongyu He Yafei Shao Ruilong Zheng Feiruo Huang department of animal nutrition and feed science College of Animal Science and Technology Huazhong Agricultural University

The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase(GDH) catalyzes the reversible inter-conversion of glutamate to ammonia. To determine the mechanism of leucine regulating GDH, pigs weighing 20 ± 1 kg were infused for 80 min with ammonium chloride or alanine in the presence or absence of leucine. Primary pig hepatocytes were incubated with or without leucine. In the in vivo experiments with either ammonium or alanine as the nitrogen source, addition of leucine significantly inhibited ureagenesis and promoted the production of glutamate and glutamine in the perfused pig liver(P 0.05), while m TORC1 signaling was *** exerted no significant changes in both GDH activity and SIRT4 gene expression in rapamycin treated hepatocytes(P > 0.05). In conclusion, L-leucine increases GDH activity and stimulates glutamate synthesis from different nitrogen sources by regulating m TORC1/SIRT4 pathway in the liver of pigs.

关键词： Glutamate dehydrogenase activity Glutamate synthesis L-leucine mTORC1/SIRT4 pathway Pig liver

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Fatty acids, inflammation and intestinal health in pigs

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Journal of animal science and Biotechnology 2016年第3期7卷 321-329页

作者： Yulan Liu Hubei Collaborative Innovation Center for animal nutrition and feed Safety Hubei Key Laboratory of Animal Nutrition and Feed ScienceWuhan Polytechnic University

The intestine is not only critical for nutrient digestion and absorption, but also is the largest immune organ in the ***, in pig production, inflammation induced by numerous factors, such as pathogen infection and stresses（e.g.,weaning）, results in intestinal mucosal injury and dysfunction, and consequently results in poor growth of pigs. Dietary fatty acids not only play critical roles in energy homeostasis and cel ular membrane composition, but also exert potent effects on intestinal development, immune function, and inflammatory response. Recent studies support potential therapeutic roles for specific fatty acids（short chain and medium chain fatty acids and long chain polyunsaturated fatty acids） in intestinal inflammation of pigs. Results of these new lines of work indicate trophic and cytoprotective effects of fatty acids on intestinal integrity in pigs. In this article, we review the effect of inflammation on intestinal structure and function, and the role of specific fatty acids on intestinal health of pigs, especial y under inflammatory conditions.

关键词： Fatty acids Inflammation Intestine Pigs

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Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells:a feed-back regulation by mechanistic target of rapamycin complex 1(mTORC1)

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Journal of animal science and Biotechnology 2018年第3期9卷 607-617页

作者： Yun Ji Xuan Luo Ying Yang Zhaolai Dai Guoyao Wu Zhenlong Wu State Key Laboratory of animal nutrition Department of Animal Nutrition and Feed Science China Agricultural University department of animal science Texas A&M University College Station

Background: Endoplasmic reticulum(ER) stress is associated with multiple pathological processes of intestinal diseases. Despite a critical role of mechanistic target of rapamycin complex 1(m TORC1) in regulating cellular stress response, the crosstalk between m TORC1 and ER stress signaling and its contribution to the intestinal barrier function is ***: In the present study, we showed that intestinal epithelial cells(IEC-6) incubated with tunicamycin led to caspase-3-dependent apoptotic cell death. The induction of cell death was accompanied by activation of unfolded protein response as evidenced by increased protein levels for Bi P, p-IRE1α, p-e IF2α, p-JNK, and CHOP. Further study demonstrated that tunicamycin-induced cell death was enhanced by rapamycin, a specific inhibitor of m ***, tunicamycin decreased transepithelial electrical resistance(TEER) and increased permeability of the cells. These effects of tunicamycin were exacerbated by m TORC1 ***: Taken together, the data presented here identified a previously unknown crosstalk between an unfold protein response and m TORC1 signaling in the intestinal epithelium. This feed-back loop regulation on ER stress signaling by m TORC1 is critical for cell survival and intestinal permeability in epithelial cells.

关键词： Apoptosis Barrier function ER stress Intestinal epithelial cell mTORC1

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Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

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Journal of animal science and Biotechnology 2020年第3期11卷 853-865页

作者： Tongxin Wang Weilei Yao Juan Li Yafei Shao Qiongyu He Jun Xia Feiruo Huang department of animal nutrition and feed science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China

Background:The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were ***:One hundred forty four weaned piglets(Duroc×Yorkshire×Landrace)from 16 pens(9 piglets per pen)were randomly divided into four treatment groups:controls(CON)or those supplemented with 200 mg/kg(LOW),400 mg/kg(MID),or 600 mg/kg(HIGH)diet *** 14-day trial,three piglets per pen were chosen to collect plasma,intestinal tissue and colonic digesta ***:We demonstrated for the first time that garcinol promoted growth performance,as increased average daily feed intake(ADFI)and decreased feed/gain ratio(F/G);and reduced diarrhea incidence(Pfeed additive.

关键词： Diarrhea Garcinol Gut microbiota Intestinal barrier function Weaned piglets

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Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells

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Journal of animal science and Biotechnology 2023年第4期14卷 1629-1638页

作者： Weilei Yao Tongxin Wang Lu Huang Zhengxi Bao Shu Wen Feiruo Huang department of animal nutrition and feed science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China

Background:Intestinal barrier plays key roles in maintaining intestinal *** damage can severely destroy the intestinal integrity of *** study was conducted to investigate the protective effects of embelin and its molecular mechanisms on intestinal inflammation in a porcine *** hundred sixty 21-day-old castrated weaned pigs(Duroc×Landrace×Yorkshire,average initial body weight was 7.05 d to four groups and fed with a basal diet o±0.28 kg,equal numbers of castrated males and females)were allotter a basal diet containing 200,400,or 600 mg embelin/kg for 28 *** growth performance,intestinal inflammatory cytokines,morphology of jejunum and ileum,tight junctions in the intestinal mucosa of piglets were ***-1 cells with overexpression of P300/CBP associating factor(PCAF)were treated with embelin,the activity of PCAF and acetylation of nuclear factor-κB(NF-κB)were analyzed to determine the effect of embelin on PCAF/NF-κB pathway in ***:The results showed that embelin decreased(P<0.05)serum D-lactate and diamine oxidase(DAO)levels,and enhanced the expression of ZO-1,occludin and claudin-1 protein in jejunum and ***,the expression levels of critical inflammation molecules(interleukin-1β,interleukin-6,tumor necrosis factor-α,and NF-κB)were downregulated(P<0.05)by embelin in jejunal and ileal ***,the activity of PCAF were down-regulated(P<0.05)by ***,transfection of PCAF siRNAs to IPEC-1 cell decreased NF-κB activities;embelin treatment downregulated(P<0.05)the acetylation and activities of NF-κB by 31.7%-74.6%in IPEC-1 cells with overexpression of ***:These results suggested that embelin ameliorates intestinal inflammation in weaned pigs,which might be mediated by suppressing the PCAF/NF-κB signaling pathway.

关键词： Acetylation Inflammation Intestinal barrier PCAF Weaned pig

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Lentil straw(Lens culinaris): An alternative and nutritious feed resource for kids

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animal nutrition 2018年第4期4卷 417-421页

作者： Vishal Mudgal Mukesh K.Mehta Ashok S.Rane department of animal nutrition and feed Technology College of Veterinary Science and Animal Husbandry

The scarcity of feed resources with the continuously increasing cost of usual animal feeds urgently demands searching some alternate feeds for ruminants. In this study, Barberi male kids were divided into4 groups of 5 kids(body weight 17.5 ± 1.8 kg) in each group, and ad libitum fed lentil straw(Lens culinaris;LS), LS based total mixed ration(LSTMR), urea ammoniated LS(ALS) or ALS based total mixed ration(ALSTMR) for a period of 28 days. Results showed LS was a superior feed(CP, 9.2%) for kids, but having quite high crude fibre(CF; 39.6%) and Ca:P ratio(10:1). Urea ammoniation of LS was helpful for increasing the digestible crude protein(DCP)(P feeding of ALS also increased(P < 0.01) the total N and ammonia N content of strained rumen liquor(SRL). Use of straw(LS or ALS) in TMR increased the digestibility of DM, organic matter and NFE(P < 0.01), intake of energy, as well as total volatile fatty acids concentration(P < 0.01) in the SRL. The present study suggested that optimum performance of kids may be achieved using either ALS alone or TMR with LS or ALS.

关键词： Kids Lentil straw Nutrient utilization Rumen fermentation Total mixed ration Urea ammoniation

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