Restricted feeding regimens improve white striping associated muscular defects in broiler chickens

作     者：Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao Yuming Guo Bingkun Zhang Bo Wang Hammed Ayansola;Yanhui Luo;Yan Wan;Xiaoxiao Yu;Jiaqi Lei;Kewei Yu;Chaoyong Liao;Yuming Guo;Bingkun Zhang;Bo Wang

作者机构：State Key Laboratory of Animal NutritionDepartment of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第12卷第1期

页      面：128-137页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：financially supported by the National Key R&D Program of China(2018YFE0127300) the 2115 Talent Development Program of China Agricultural University the Young Talent Supporting Program Funding of the College of Animal Science and Technology,China Agricultural University Education Foundation Grant (1041-2221002) 

主　　题：Broiler chickens Intermittent feeding Angiogenesis Satellite cells White striping 

摘      要：The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast *** the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 *** angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(P0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of ***,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P0.05).In conclusion,IF starting in the first week decreases SC *** to AL,IF or fasting promotes muscular angiogenesis,increases SC number