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Clinical profiles and outcomes of acute type A aortic dissection and intramural hematoma in the current era: lessons from the first registry of aortic dissection in China

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Chinese Medical Journal 2021年第8期134卷 927-934页

作者： Wei-Xun Duan Wei-Guang Wang Lin Xia Chao Xue Bo Yu Kai Ren Wei Yi Hong-Liang Liang Xiao-Chao Dong Jian Zuo Jin-Cheng Liu Shi-Qiang Yu Ding-Hua Yi departm ent of cardiovascular surgery Xijing Hospitalthe Fourth Military Medical UniversityXi'anShaanxi 710032China 71901 troops The Chinese People's Liberation ArmyLiaochengShandong 252000China

Background::Acute type A aortic dissection(ATAAD)and acute type A intramural hematoma(ATAIMH)are life-threatening diseases with high *** better understand their clinical features in the Chinese population,we analyzed the data from the first Registry of Aortic Dissection in China(Sino-RAD)to promote the understanding and management of the ***::All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1,2012 to December 31,2016 were *** data of patients’selection,history,symptoms,management,outcomes,and postoperation complications were analyzed in the *** continuous variables were compared using the Student’s t test for normal distributions and the Mann-Whitney U test for non-normal *** variables were compared using the Chi-square test or Fisher exact ***::A total of 1582 patients with ATAAD and 130 patients with ATAIMH were *** mean age of all patients was 48.4 *** with ATAAD were significantly younger than patients with ATAIMH(48.9 years vs.55.6 years,Pents with ATAAD was significantly higher compared to those with ATAIMH(P=0.01).The time range from the onset of symptom to hospitalization was 2.0 *** patients of ATAIMH had hypertension than that of ATAAD(82.3%vs.67.6%,Pent and in-hospital mortality was 5.3%.Patients with ATAAD mainly received surgical treatment(89.6%),while most patients with ATAIMH received medical treatment(39.2%)or endovascular repair(35.4%).Conclusions::Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention,achieving early diagnosis

关键词： Aortic dissection Acute type A aortic dissection Acute type A intramural hematoma

High salt-induced weakness of anti-oxidative function of natriuretic peptide receptor-C and podocyte damage in the kidneys of Dahl rats

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Chinese Medical Journal 2020年第10期133卷 1182-1191页

作者： Xiao-Long Zhu Tao Zhang Zhen-Qiang Xu Xiao-Chun Ma Zheng-Jun Wang Cheng-Wei Zou Jing-Xin Li Hai-Yan Jing departm ent of cardiovascular surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandong 250021China department of Physiology Medical School of Shandong UniversityJinanShandong 250021China department of Pathology Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandong 250021China.

Background:Atrial natriuretic peptide(ANP)and its natriuretic peptide receptors A(NPR-A)and C(NPR-C)are involved in the regulation of physiological and pathophysiological process of blood *** present study aimed to determine the role of NPR-C in the development of salt-sensitive ***::The Dahl salt-sensitive(DS)and salt-resistant(DR)rats were used in this *** were matched according to their age and weight,and then placed on either a high-salt(HS,8%)or a normal-salt(NS,0.4%)diet for 6 weeks randomly using random number *** systolic blood pressure(SBP),plasmatic sodium concentration(PL Na),urinary sodium excretion(UV Na),and serum creatinine concentration(Scr)were *** concentration of ANP in blood and tissues(heart and kidney)was detected by enzyme-linked immunosorbent *** expression of ANP,NPR-A,and NPR-C in kidney was evaluated with western blot *** renal redox state,the concentration changes in malondialdehyde(MDA),lipofuscin,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(Nox),and nitric oxide synthase(NOS)in kidney were detected by a spectrophotometric *** kidney damage was evaluated using pathological techniques and the succinodehydrogenase(SDHase)***,after an intra-peritoneal injection of C-atrial natriuretic peptide(ANP)4-23(C-ANP 4-23),an NPR-C receptor agonist,the SBP,biochemical values in blood and urine,and renal redox state were *** paired Student’s t test and analysis of variance followed by the Bonferroni test were performed for statistical analyses of the comparisons between two groups and multiple groups,***::The baseline SBP in all groups was within the normal *** the end of the 6-week experiment,HS diet significantly increased the SBP in DS rats from 116.63±2.90 mmHg to 162.25±2.15 mmHg(t=-10.213,P<0.001).The changes of SBP were not significant in DS rats on an NS diet and DR rats on an NS diet or on an HS diet(

关键词： Natriuretic peptide receptor-C Nicotinamide adenine dinucleotide phosphate oxidase 4 Oxidative stress Podocyte Salt-sensitive hypertension

The best option for complicated type B dissection with arch involved

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Chinese Medical Journal 2021年第8期134卷 883-885页

作者： Chang Shu Tun Wang Ming-Yao Luo Kun Fang Quan-Ming Li Ming Li Xin Li Hao He departm ent of Vascular surgery The 2nd Xiang-ya HospitalCentral South UniversityChangshaHunan 410011China Angiopathy Institute Central South UniversityChangshaHunan 410011China department of cardiovascular surgery Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai HospitalBeijing 100013China.

Thoracic endovascular aortic repair(TEVAR)is the first choice of type B aortic dissection(T B A D).U However,when the dissection involves an aortic arch with close proximity to the supra-aortic branches,the situation becomes complicated and challenging for classical *** recent years,the Hybrid-ENDO vascular-Open arch repair(HENDO)theory that consists of some treatment strategies specifically for aortic arch lesions,becomes *** on the HENDO theory,the modified endovascular technique,simultaneously aiming at the reconstruction of the involved supra-aortic branches and coverage of TBAD,is the first choice with promising future *** to the specific anatomic situation and the pathology of the disease,hybrid or open surgery can be performed selectively.

关键词： dissection arch complicated

DYNAMIC ANALYSIS OF FLUID-STRUCTURE INTERACTION OF ENDOLYMPH AND CUPULA IN THE LATERAL SEMICIRCULAR CANAL OF INNER EAR

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Journal of Hydrodynamics 2011年第6期23卷 777-783页

作者： WU Cai-qin HUA Cheng YANG Lin DAI Pei-dong ZHANG Tian-yu WANG Ke-qiang department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Eye and ent Hospital of Fudan University Shanghai 200031 China cardiovascular Disease Institute Zhongshan Hospital of Fudan University Shanghai 200032 China

The semicircular canals, composed of lateral, anterior and posterior canals in the inner ear, are the sensors of equilibrium during head rotation movements in the three-dimensional space. Semicircular canals are filled with endolymph confined by the cupula. The study of the relationship between endolymph flow and cupular deformation is important in revealing the semicircular canals biomechanical behavior. To date, there are few studies focusing on the transient endolymph flow and cupular deformation in response to a head rotation motion. The lateral semicircular canal is mainly responsible for the sense of the horizontal rotation movement. In order to figure out the intricate dynamics in the lateral semicircular canal during the head rotation motion, the time evolutions of both endolymph flow and cupular deformation are analyzed in this article by using a fully coupled fluid-structure interaction model. It is shown that the cupular deformation provides cues for understanding the physiology of sensing the head rotation.

关键词： fluid-structure interaction endolymph cupula finite element method

Association between cumulative blood pressure and long-term risk of cardiovascular disease: findings from the 26-year Chinese Multi-provincial Cohort Study-Beijing Project

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Chinese Medical Journal 2021年第8期134卷 920-926页

作者： Shuai Liu Dong Zhao Miao Wang Yue Qi Jia-Yi Sun Jun Liu Yan Li Jing Liu departm ent of Epidemiology Beijing An Zhen HospitalCapital Medical UniversityBeijing 100029China Beijing Institute of Heart Lungand Blood Vessel DiseasesBeijing 100029China The Key Laboratory of Remodeling-Related cardiovascular Diseases Ministry of EducationBeijing 100029China The Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing 100029China

Background::Cumulative blood pressure(BP),a measure incorporating the level and duration of BP exposure,is associated with the risk of cardiovascular disease(CVD).However,the level at which cumulative BP could significantly increase the risk remains *** study aimed to investigate the association of 15-year cumulative BP levels with the long-term risk of CVD,and to examine whether the association is independent of BP levels at one ***::Data from a 26-year follow-up of the Chinese Multi-provincial Cohort Study-Beijing Project were *** BP levels between 1992 and 2007 were calculated among 2429 participants free of CVD in *** events(including coronary heart disease and stroke)occurring from 2007 to 2018 were *** hazard ratios(HRs)for CVD incidence associated with quartiles of cumulative systolic blood pressure(SBP)and diastolic blood pressure(DBP)were ***::Of the 2429 participants,42.9%(1042)were men,and the mean age in 2007 was 62.1±7.9 ***,207 CVD events occurred during the follow-up from 2007 to *** with higher levels of cumulative SBP or DBP exhibited a higher incidence rate of CVD(Pents in 2007,15-year cumulative BP levels higher than the median,that is,1970.8/1239.9 mmHg·year for cumulative SBP/DBP,which were equivalent to maintaining SBP/DBP levels of 131/83 mmHg or above on average in 15 years,were associated with higher risk of CVD in subsequent years independent of BP measurements at one-time ***::Cumulative exposure to m

关键词： Blood pressure cardiovascular disease Cohort study

Solitary fibrous tumor: a 10-year retrospective analysis with several rare cases

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Chinese Medical Journal 2021年第8期134卷 1006-1008页

作者： Ke Zhang Hui-Juan Liu Zhang-Bo Cheng Mi Deng Jing Luo Xin Qi departm ent of Pathology the Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Clinical Research Center of Ophthalmic Disease ChangshaHunan 410011China department of cardiovascular surgery Fujian Provincial HospitalFujian Medical SchoolFuzhouFujian 350001China

To the Editor:Solitary fibrous tumors(SFTs)are mesenchymal neoplasms and were first described in pleura,then subsequently found in extrapleural organs,such as peritoneum,lung,parotid gland,paranasal sinuses,orbit,skin,and intracranial areas.1 However,extrapleural SFTs are limited to isolated case *** of the rarity of them,the related information is far from sufficient and thus,leading this tumor under fully *** to the World Health Organization(WHO)classification,SFTs are pluripotent neoplasms that could be benign,intermediate,or *** of above drive us to further understand the epidemiology,clinical characteristics,medical therapy,and prognosis of this disease.

关键词： neoplasms epidemiology organs

Thrombosis: Novel nanomedical concepts of diagnosis and treatment

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World Journal of Cardiology 2015年第8期7卷 434-441页

作者： Iwona Cicha cardiovascular Nanomedicine Unit Section of Experimental Oncology and Nanomedicine ENT-DepartmentUniversity Hospital Erlangen

Intravascular thrombosis, a critical pathophysiological feature of many cardiovascular disorders, leads to the formation of life-threatening obstructive blood clots within the vessels. Rapid recanalization of occluded vessels is essential for the patients' outcome, but the currently available systemic fibrinolytic therapy is associated with low efficacy and tremendous side effects. Additionally, many patients are ineligible for systemic thrombolytic therapy, either due to delayed admission to the hospital after symptom onset, or because of recent surgery, or bleeding. In order to improve the treatment efficacy and to limit the risk of hemorrhagic complications, both precise imaging of the affected vascular regions, and the localized application of fibrinolytic agents, are required. Recent years have brought about considerable advances in nanomedical approaches to thrombosis. Although these thrombustargeting imaging agents and nanotherapies are not yet implemented in humans, substantial amount of successful in vivo applications have been reported, including animal models of stroke, acute arterial thrombosis, and pulmonary embolism. It is evident that the future progress in diagnosis and treatment of thrombosis will be closely bound with the development of novel nanotechnology-based strategies. This Editorial focuses on the recently reported approaches, which hold a great promise for personalized, disease-targeted treatment and reduced side effects in the patients suffering from this life-threatening condition.

关键词： Thrombosis Thrombus imaging Nanome-dicine Targeted nanoparticles Thrombolytic drug-delivery systems

Correlation of CD19+CD24hiCD38hl B cells in coronary artery disease with severity of atherosclerosis

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Chinese Medical Journal 2020年第10期133卷 1257-1258页

作者： Yang Liu Wei-Ran Duan Sa Liu Tong Liu Ying-Jun Chang Xiang-Ming Fan departm ent of Cardiac surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China The Key Laboratory of Remodeling-related cardiovascular Disease Ministry of educationBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing 100029China department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Peking University People's Hospital and Peking University Institute of Hematology Beijing 100044China.

To the Editor:Atherosclerosis is a chronic inflammatory disease that involves multiple types of immune *** immunity exerts diverse and profound effects on *** effector phenotype of lesional T cells may affect lesion growth and *** T cells with anti-inflammatory properties have been reported in atherosclerotic *** targets of suppression of regulatory T cells include naive and effector CD4+and CD8+T cells,dendritic cells,and macrophages.A new subset of B cells,with CD19+CD24h,CD38hl phenotype in humans,is becoming a hot issue in the field of autoimmunity such as systemic lupus erythematosus and arthritis.*11 These regulatory B cells(Bregs)play important roles in immune system by regulating functions of effector and regulatory T *** exhibit protective role by attenuating the neointimal formation of atherosclerosis through an interleukin 10(IL-10)mediated mechanism in a experimental study.121 There have been few studies on human Bregs in atherosclerosis disease until *** this study we aimed to investigate CD 19+CD24hlCD38hl B cells in coronary artery disease(CAD)patients requiring coronary artery bypass graft(CABG)surgery.

关键词： CD24 CD38 atherosclerosis

Predictors of super-response to cardiac resynchronization therapy： the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing

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Journal of Geriatric Cardiology 2017年第12期14卷 737-742页

作者： Han JIN Min GU Wei HUA Xiao-Han FAN Hong-Xia NIU Li-Gang DING Jing WANG Cong XUE Shu ZHANG The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Background Super-responders （SRs） are defined as patients who show crucial cardiac function improvement after cardiac resynchro- nization therapy （CRT）. The purpose of this study is to identify and validate predictors of SRs after CRT. Methods This study enrolled 201 patients who underwent CRT during the period from 2010 to 2014. Clinical and echocardiographic evaluations were conducted before CRT and 6 months after. Patients with a decrease in New York Heart Association （NYHA） fimctional class 〉 1, a decrease in left ventricular end-systolic volume （LVESV） ≥ 15%, and a final left ventricular ejection fraction （LVEF） ≥ 45% were classified as SRs. Results 29% of the 201 patients who underwent CRT were identified as SRs. At baseline, SRs had significantly smaller left atrial diameter （LAD）, LVESV, left ventricular end-diastolic volume （LVEDV） and higher LVEF than the non-super-responders （non-SRs）. The percentage of patients using angiotensin-converting enzyme inhibitors or angiotensin receptor blockers （ACEI/ARB） was higher in SRs than non-SRs. Most SRs had Biventricular （BiV） pacing percentage greater than 98% six months after CRT. In the multivariate logistic regression analysis, the independ- ent predictors of SRs were lower LVEDV [odd ratios （OR）： 0.93; confidence intervals （CI）： 0.90-0.97], use of ACEI/ARB （OR： 0.33; CI： 0.13~3.82） and BiV pacing percentage greater than 98% （OR： 0.29; CI： 0.16~.87）. Conclusion Patients with a better compliance of ACEI/ARB and a less ectatic ventricular geometry before CRT tends to have a greater probability of becoming SRs. Higher percentage of BiV pacing is essential for becoming SRs.

关键词： Biventricular pacing Cardiac resynchronization therapy Heart failure Super-responders