Association between cumulative blood pressure and long-term risk of cardiovascular disease: findings from the 26-year Chinese Multi-provincial Cohort Study-Beijing Project

作     者：Shuai Liu Dong Zhao Miao Wang Yue Qi Jia-Yi Sun Jun Liu Yan Li Jing Liu Liu Shuai;Zhao Dong;Wang Miao;Qi Yue;Sun Jia-Yi;Liu Jun;Li Yan;Liu Jing

作者机构：Departm ent of EpidemiologyBeijing An Zhen HospitalCapital Medical UniversityBeijing 100029China Beijing Institute of HeartLungand Blood Vessel DiseasesBeijing 100029China The Key Laboratory of Remodeling-Related Cardiovascular DiseasesMinistry of EducationBeijing 100029China The Beijing Municipal Key Laboratory of Clinical EpidemiologyBeijing 100029China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第8期

页      面：920-926页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Key Research and Development Program of China(No.2016YFC0900902) the Capital’s Funds for Health Improvement and Research(No.020-1-1051 and the Beijing Nova Programme Interdisciplinary Cooperation Project(No.Z191100001119017)) 

主　　题：Blood pressure Cardiovascular disease Cohort study 

摘      要：Background::Cumulative blood pressure(BP),a measure incorporating the level and duration of BP exposure,is associated with the risk of cardiovascular disease(CVD).However,the level at which cumulative BP could significantly increase the risk remains *** study aimed to investigate the association of 15-year cumulative BP levels with the long-term risk of CVD,and to examine whether the association is independent of BP levels at one ***::Data from a 26-year follow-up of the Chinese Multi-provincial Cohort Study-Beijing Project were *** BP levels between 1992 and 2007 were calculated among 2429 participants free of CVD in *** events(including coronary heart disease and stroke)occurring from 2007 to 2018 were *** hazard ratios(HRs)for CVD incidence associated with quartiles of cumulative systolic blood pressure(SBP)and diastolic blood pressure(DBP)were ***::Of the 2429 participants,42.9%(1042)were men,and the mean age in 2007 was 62.1±7.9 ***,207 CVD events occurred during the follow-up from 2007 to *** with higher levels of cumulative SBP or DBP exhibited a higher incidence rate of CVD(P0.001).Compared with the lowest quartile of cumulative SBP,the HR for CVD was 1.03(95%confidence interval[CI]:0.59-1.81),1.69(95%CI:0.99-2.87),and 2.20(95%CI:1.21-3.98)for the second to the fourth quartile of cumulative SBP,and 1.46(95%CI:0.86-2.48),1.99(95%CI:1.18-3.35),and 2.08(95%CI:1.17-3.71)for the second to the fourth quartile of cumulative DBP,*** further cross-combined group analyses with BP measurements in 2007,15-year cumulative BP levels higher than the median,that is,1970.8/1239.9 mmHg·year for cumulative SBP/DBP,which were equivalent to maintaining SBP/DBP levels of 131/83 mmHg or above on average in 15 years,were associated with higher risk of CVD in subsequent years independent of BP measurements at one-time ***::Cumulative exposure to m