Correlation of CD19+CD24hiCD38hl B cells in coronary artery disease with severity of atherosclerosis

作     者：Yang Liu Wei-Ran Duan Sa Liu Tong Liu Ying-Jun Chang Xiang-Ming Fan Liu Yang;Duan Wei-Ran;Liu Sa;Liu Tong;Chang Ying-Jun;Fan Xiang-Ming

作者机构：Departm ent of Cardiac SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China The Key Laboratory of Remodeling-related Cardiovascular DiseaseMinistry of educationBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing 100029China Department of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Peking University People's Hospital and Peking University Institute of HematologyBeijing 100044China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第10期

页      面：1257-1258页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：CD24 CD38 atherosclerosis 

摘      要：To the Editor:Atherosclerosis is a chronic inflammatory disease that involves multiple types of immune *** immunity exerts diverse and profound effects on *** effector phenotype of lesional T cells may affect lesion growth and *** T cells with anti-inflammatory properties have been reported in atherosclerotic *** targets of suppression of regulatory T cells include naive and effector CD4+and CD8+T cells,dendritic cells,and macrophages.A new subset of B cells,with CD19+CD24h,CD38hl phenotype in humans,is becoming a hot issue in the field of autoimmunity such as systemic lupus erythematosus and arthritis.*11 These regulatory B cells(Bregs)play important roles in immune system by regulating functions of effector and regulatory T *** exhibit protective role by attenuating the neointimal formation of atherosclerosis through an interleukin 10(IL-10)mediated mechanism in a experimental study.121 There have been few studies on human Bregs in atherosclerosis disease until *** this study we aimed to investigate CD 19+CD24hlCD38hl B cells in coronary artery disease(CAD)patients requiring coronary artery bypass graft(CABG)surgery.