检索结果-南通市图书馆

FdG-Pet AS A ROUTINE SURVEILLANCE TOOL IN HEAd ANd NECK CARCINOMA SIX MONTHS AFTER TREATMENT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Shanghai Second Medical University(Foreign Language Edition) 2009年第1期21卷 25-31页

作者：徐雅男 Sophie Pri 王家东 department of Otolaryngology Head and Neck Surgery RenJi HospitalSchool of MedicineShanghai Jiaotong University Service d'orl et chirurgie cervico-faciale Universit Pierre et Marie CurieParis 6Hpital Tenon APHP4 rue de la Chine Institution of Otorhinolaryngology of Shanghai Jiaotong University

Objective To evaluate prospectively the impact of fluorodeoxyglucose-fluorine-18 positron emission tomography (FdG-Pet) in the detection of recurrence, second primary cancers, and distant metastases in head and neck squamous cell carcinoma (HNSCC) 6 months after treatment. Methods A total of 41 patients without any clinical element for recurrence, second primary cancer, or distant metastases received a whole-body FdG-Pet as a routine surveillance tool 6 months after initial combined curative therapy for HNSCC. Results There were 35 negative Pet results and 6 positive. One patient with abnormal FdG-Pet did not have recurrent HNSCC (false positive). Five had true positive results: proven recurrence in 2 patients, second primary cancer in 2, and distant metastasis in 1. The sensitivity and specificity of FdG-Pet for the diagnosis of HNSCC recurrence, second tumor, and distant metastases were 100% (5/5) and 97.2% (35/36), respectively. The positive predictive value was 83.3% (5/6). The negative predictive value was 100% (35/35). The overall accuracy was 97.6% (40/41). FdG-Pet had a therapeutic impact in 5 of 41 patients (12.2%). There was no impact of FdG-Pet on management in other 36 patients. Conclusion FdG-Pet is useful as primary method for detecting nodal recurrence and distant metastases in HNSCC as well as second cancer in subclinical patients as it had a high effectiveness. But systematic FdG-Pet performed at 6 months in patients without any clinical suspicion of local recurrence was scarcely useful.

关键词： fluorodeoxyglucose-fluorine-18 positron emission tomography head and neck squamous cell carcinoma surveillance

Embryology of the nose:The evo-devo concept

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology 2016年第2期6卷 33-40页

作者： Roger Jankowski Samuel Márquez Service orl et chirurgie cervico-faciale Centre Hospitalier Régional Universitaire Faculté de Médecine Université de Lorraine departments of Cell Biology and Otolaryngology SUNY Downstate Medical Center

Aim was to gather relevant knowledge in evolution and development to find a rational explanation for the intricate and elaborate anatomy of the nose. According to classic embryology, the philtrum of the upper lip, nasal dorsum, septum and primary palate develop from the intermaxillary process, and the lateral walls of the nasal pyramid from the lateral nasal processes. The palatal shelves, which are outgrowths of the maxillary processes, form the secondary palate. The median nasal septum develops inferiorly from the roof of the nasal cavity. These valuable embryologic data do not explain the complex intricacy of the many anatomical structures comprising the nose. The evo-devo theory offers a rational explanation to this complex anatomy. Phylogenically, the nose develops as an olfactory organ in fish before becoming respiratory in tetrapods. during development, infolding of the olfactory placodes occurs, bringing the medial olfactory processes to form the septolateral cartilage while the lateral olfactory processes form the alar cartilages. The olfactory fascia units these cartilages to the olfactory mucosa, that stays separated from brain by the cartilaginous olfactory capsule(the ethmoid bone forerunner). Phylogenically, the respiratory nose develops between mouth and olfactory nose by rearrangement of the dermal bones of the secondary palate, which appears in early tetrapods. during development, the palatal shelves develop into the palatine processes of the maxillary bones, and with the vomer, palatine, pterygoid and inferior turbinate bones form the walls of the nasal cavity after regression of the transverse lamina. Applying the evolutionary developmental biology(evo-devo) discipline on our present knowledge of development, anatomy and physiology of the nose, significantly expands and places this knowledge in proper perspective. The clinicopathologies of nasal polyposis, for example, occurs specifically in the ethmoid labyrinth or, woodworker's adenocarcinomas,

关键词： Nose Evo-devo Embryology development Anatomy

First Cases of Amygdaloid Cyst in Adults in djibouti: Case Report of Two Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Otolaryngology and Head & Neck Surgery 2023年第3期12卷 124-134页

作者： Abdallah Witti Adou Awaleh Ahmed Awaleh Goumaneh Omar Kamil Ahmed Kamil Service orl et chirurgie cervico-faciale Centre médico-chirurgical de la Police Nationale Djibouti Africa Service de cancérologie Centre médico-chirurgical de la Police Nationale Djibouti Africa Service d’anatomopathologie H&#244pital de la CNSS Djibouti Africa Service d’anesthésie et réanimation Centre médico-chirurgical de la Police Nationale Djibouti Africa

Amygdaloid cysts are rare cystic benign tumors due to congenital malformations resulting from an anomaly of embryonic development of the upper laterocervical region, originating from the second branchial cleft. They represent approximately 2% of all laterocervical tumors and 6% to 85% of anomalies of the second branchial cleft. This anomaly of the second branchial cleft is a frequent reason for consultation in the pediatric population but is relatively rare in adults. We report the cases of two patients aged 23 and 34 years with no particular pathological history. They were presenting a laterocervical swelling, one right and the other left, painless, evolving for two years for the first and for 10 years for the second, gradually increasing in volume without any other associated signs the diagnosis of which after radiological exploration (ultrasound and CT scan) was that of an amygdaloid cyst. A cervicotomy with anatomopathological examination of the surgical specimen confirmed the diagnosis of the amygdaloid cyst. The objective is to analyze the anatomo-clinical and therapeutic particularities of this pathology and to compare it with data from the literature.

关键词： Amygdaloid Cyst Second Branchial Cleft Surgery djibouti

*** pattern of proteases secretion in Fuchs corneal endothelial dystrophy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2019年第1期 202-202页

作者： Isabelle Xu Mathieu Thériault Stéphanie Proulx Centre de Recherche en Organogénèse Expérimentale de l’UniversitéLaval/LOEX QuébecQCCanada Centre de Recherche du CHU de Québec-UniversitéLaval Axe Médecine RégénératriceQuébecQCCanada département d’ophtalmologie et d’orl-chirurgie cervico-faciale Facultéde MédecineUniversitéLavalQuébecQCCanada

Background:The goal of this project was to analyze the relationship between cell morphology and proteases/proteases inhibitors(PIs)secretion profile in fuchs endothelial corneal dystrophy(FECd)corneal endothelial cells(CECs).Methods:Cell morphology was determined using a circularity index(4π×area/perimeter2)for each CECs population extracted from surgical FECd specimens(N=2)and healthy Eye bank corneas(N=3).CECs were cultured 28 days *** was collected and analysed using Proteome Profiler Array detecting 35 proteases and 32 PIs(R&d Systems).Proteome signal was analyzed using Image Studio Lite and correlated with the population’s circularity ***:Calculation of circularity index reported different morphologies among FECd populations(0.59±0.18 and 0.64±0.17)and healthy populations(0.44±0.18,0.66±0.13 and 0.71±0.11).Proteome arrays revealed the presence of 10 proteases(AdAMTS1,Cathepsin A,B,d,and X/Z/P,dPPIV/Cd26,MMP-2,3 and 12,uPA/Urokinase)and 10 PIs(Protease Nexin II,Cystatin B and C,EMMPRIN/Cd147,Latexin,Lipocalin-1,Serpin E1,TFPI,TFPI-2,TIMP-1,2 and 4).Healthy and FECd specimens showed similar variation patterns according to morphology for secretion of AdAMTS1,MMP-3 and ***,opposing patterns between healthy and FECd populations were observed for Cathepsin B and ***,some proteins did not show variation according to phenotype in healthy CECs,but did in FECd CECs:Cathepsin A,Cystatin C,TFPI-2 and total *** the other proteins,secretion did not vary according to morphology or no specific pattern was ***:To conclude,our results suggest that cell phenotype is linked to the secretion of certain proteases/PIs in both ***,there seems to be differences in secretion of particular proteases and PIs between FECd and healthy specimens as morphology did not have a similar *** differences might initiate an imbalance between proteases and PIs explaining the irregular thickening of the

关键词： Fuchs endothelial corneal dystrophy(FECd) cornea corneal endothelial cells(CECs) protease phenotype

*** stress induced in retinal pigmented epithelium cells by the synergy between polycyclic aromatic hydrocarbons and blue light

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2018年第1期 450-450页

作者： Corinne Zinflou Patrick J.Rochette Axe Médecine Régénératrice Centre de Recherche du CHU de QuébecUniversitéLavalHôpital du Saint-SacrementQuébecQCCanada Centre de Recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX UniversitéLavalQuébecQCCanada département d’ophtalmologie et orl-chirurgie cervico-faciale UniversitéLavalQuébecQCCanada

Background:Lesion to the retinal pigment epithelium(RPE)is a crucial event in age-related macular degeneration(AMd)*** the pathogenesis of this complex disease is poorly understood,sunlight exposure and smoking are major environmental risk factors associated with ***-energy visible blue light(HEV;400-500 nm)is the most energetic and potentially harmful solar wavelengths reaching adults *** the other hand,RPE cells can be exposed to a large range of pollutants from cigarette smoke,with polycyclic aromatic hydrocarbons(PAH)being among the most *** PAH from cigarette smoke can absorb HEV *** led us hypothesize that in RPE cells,the combination of PAH and HEV could synergize to exacerbate the stress caused by either factor *** thus investigate the combined effect of PAH and HEV light in RPE ***:Confluent RPE immortalized cells(ARPE19)were exposed to nanomolar concentrations of benzo[a]pyrene(BaP)or indeno[1,2,3-cd]pyrene(IcdP).While IcdP efficiently absorbs HEV wavelengths,BaP,the most studied PAH,does not significantly absorb HEV light and was used as a *** or IcdP contaminated ARPE19 were then irradiated with increasing sub-lethal doses of HEV light(150-500 J/cm2)using a setup that mimics the light spectrum normally reaching the ***,apoptosis and reactive oxygen species(ROS)generation were assessed in each ***:In presence of low concentrations of IcdP,sub-lethal amounts of HEV light trigger,in a dose-dependent way,up to 70%of apoptotic cell ***-exposure to IcdP and HEV also leads to a synergistic ROS generation in ARPE19 cells,thus inducing oxidative *** of these effects were observed with *** inhibition of ROS production by specific antioxidants only decreases death by 20%in cells simultaneously exposed to both IcdP and HEV ***:Low concentrations of IcdP synergize with HEV light to induce phototoxicity in ARPE19 *** increased oxidat

关键词： Retinal pigment epithelium(RPE) polycyclic aromatic hydrocarbons(PAH) blue light oxidative stress age-related macular degeneration(AMd)

*** tissues bank for vision health research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2018年第1期 499-499页

作者： Kim Santerre Mathieu Thériault Sylvain Chemtob Lucie Germain Claude Giasson Sylvain Guérin Solange Landreville Patrick JRochette Christian Rochette Mike Sapieha Élodie Boisselier Vincent Pernet Stéphanie Proulx Centre de Recherche du CHU de Québec-UniversitéLaval Axe Médecine RégénératriceQuébecQCCanada Centre de Recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX QuébecQCCanada département d'ophtalmologie et d'Oto-Rhino-Laryngologie-chirurgie cervico-faciale Facultéde MédecineUniversitéLavalQuébecQCCanada département d’ophtalmologie Universitéde MontréalQCCanada Maisonneuve-Rosemont Hospital Research Center MontrealQCCanada département de chirurgie Facultéde MédecineUniversitéLavalQuébecQCCanada École d’optométrie Universitéde MontréalQuébecQCCanada

Background:This infrastructure delivers biological material necessary for several research projects to Vision Health Research Network investigators(VHRN).Methods:Héma-Québec is the organism in charge obtaining consent and retrieving donor eyes for patient treatment or for *** Quebec City,donor eyes are sent to the eye bank of the“Centre Universitaire d’ophtalmologie”(CUO)of Saint-Sacrement *** at the eye bank evaluate the quality of the *** unfit for graft are transferred to the infrastructure where the coordinator encodes samples prior to their ***:Between 2013 and 2017,27 fundamental investigators,clinical investigators and collaborators supported by 60 students,trainees and laboratory assistants used this infrastructure to move forward their *** 2013,results from those projects generated 21 scientific publications and 232 *** infrastructure helped VHRN investigators obtain near 4 million dollars in grants from many organisms(CIHR,NSERC,Foundations,etc.).These grants allowed recruitment and formation of highly qualified *** year(April 2016 to March 2017),189 corneas and 23 eyes transited through the ***:This infrastructure is available for all investigators that are members of the *** original projects have been elaborated thanks to the human ocular tissues provided by this *** projects will advance our knowledge in vision health.A better understanding of eye functions will lead to new treatments for eye diseases.

关键词： Human ocular tissues for research fresh tissues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2018年第1期 413-413页

作者： Stéphanie Proulx Centre de Recherche du CHU de Québec-UniversitéLaval Axe Médecine RégénératriceHôpital du Saint-SacrementQuébecCanada Centre de Recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX QuébecCanada département d'ophtalmologie et d'Oto-Rhino-Laryngologie-chirurgie cervico-faciale Facultéde MédecineUniversitéLavalQuébecCanada

Background:The goal of this study was to engineer an epithelialized and endothelialized pigmented choroidal substitute using the self-assembly approach of tissue ***:Cells from human choroids were isolated and *** purity was assessed using immunostaining(Cd31,HMB45,vimentin,keratins 8/18).To engineer the choroid,fibroblasts were cultured in the presence of serum and ascorbic acid to promote extracellular matrix(ECM)*** cells,melanocytes or RPE cells were separately seeded on the stromal *** substitutes were further characterized by histology,mass spectrometry,immunostaining,and compared to native human ***:The technique used to isolate choroidal cells yielded pure cultures of fibroblasts,melanocytes and vascular endothelial *** stromal substitutes engineered using the self-assembly approach were composed of collagen(types I,VI,XII and XIV),proteoglycans(decorin,lumican)and other ECM *** expression was confirmed using *** cells spontaneously assembled into capillary-like structures and vascular networks when cocultured with fibroblast-containing ECM ***:This study shows that the self-assembly approach of tissue engineering can be used to reconstruct a choroid using native *** model represents a unique tool to better understand the crosstalk between the different choroidal cell types and cell-ECM interactions.

关键词： Tissue engineering choroid self-assembly