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Novel Thrice-Weekly Isoniazid plus Rifapentine Short-Course Regimen for the Treatment of Latent Tuberculosis Infection in a Murine Model

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infectious diseases & Immunity 2024年第3期4卷 138-141页

作者： Qiaoling Ruan Jingyu Zhou Shufeng Weng Lingyun Shao Wenhong Zhang Department of infectious diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life ScienceFudan UniversityShanghai 200438China Shanghai Sci-Tech Inno center for Infection&Immunity Shanghai 200052China.

*** Tuberculosis(TB),caused by Mycobacterium tuberculosis,remains a leading cause of death among infectious diseases *** tuberculosis infections(LTBI)contribute to the global burden of TB *** preventive treatment(TPT)is a key intervention to achieve the End TB Strategy *** World Health Organization recommends LTBI treatment regimens,including 6 or 9 months of once-daily isoniazid(INH,H),4 months of once-daily rifampin(RIF,R),3 months of once-weekly rifapentine(RPT,P)plus INH(3HP),3 months of once-daily RIF plus INH,or 1 month of daily RPT plus INH(1HP).Clinicians and individuals with LTBI may be reluctant to implement TPT due in part to concerns regarding adherence to the long treatment duration and drug toxicity of the currently recommended LTBI treatment ***,better-tolerated,and cost-effective TPT regimens are highly *** is a long-acting rifamycin,and rifamycin-based regimens are now the preferred LTBI treatment because they have similar or better efficacy and higher completion rates due to their shorter *** on our experiences with TPT practice among Chinese people with silicosis,we found that the 3HP regimen was not well tolerated due to an unexpectedly high frequency of adverse events(AEs)(70.4%)and grade 3 or 4 AEs(7.9%),especially the high incidence of flu-like systemic drug reactions(SDRs)(10.8%).

关键词： regimen Tuberculosis treatment

Global outreach and networking promotion to accelerate tropical diseases elimination

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贫困所致传染病(英文) 2024年第03期13卷 1-5页

作者： Lv Shan Zhou Xiao-Nong National Institute of Parasitic diseases at Chinese center for Disease Control and Prevention (Chinese center for Tropical diseases research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases Shanghai People’s Republic of China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Hainan center for Tropical diseases research (Hainan Subcenter of Chinese center for Tropical diseases research) Haikou People’s Republic of China

Cooperation and networking are powerful tools in the combating against tropical diseases. Cooperation on a global scale is essential due to the transboundary nature of tropical diseases. Networking plays a pivotal role in facilitating such cooperation. Both cooperation and networking can foster innovation in disease control programmes. Collaborative research can lead to the development of new drugs and vaccines, while shared surveillance data can enable the early detection and control of disease epidemics. Therefore, consensus of cooperation and networking has been reached during the 7th Symposium on Surveillance-Response Systems Leading to Tropical diseases Elimination, which reflected in the two documents, i.e.,Consensus for Transboundary Tropical diseases Control, andAction Consensus of the Network of WHO Collaborating Centres Related to NTDs. These documents will improve the efforts in the fighting against tropical diseases through collective actions to achieve the United Nations’ Sustainable Development Goals (SDGs).

关键词： Tropical diseases Cooperation Networking Elimination Sustainable development goals

Isolation and characterization of mpox virus from the first mpox case in Shenzhen,china

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Virologica Sinica 2024年第2期39卷 335-337页

作者： Lin Cheng Liuqing Yang Miao Wang Yabo Peng Haiyan Wang Xiaoxiang Yang Juanjuan Zhao Mingxia Zhang Fuxiang Wang Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalShenzhen518112China Department of infectious diseases Shenzhen Third People's HospitalShenzhen 518112China The Second Affiliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China

Dear Editor,Unlike previous outbreaks of the mpox(previously known as monkeypox),which were localized in Africa and resulted in small numbers of infections due to limited human-to-human transmission,the current outbreak beginning in May 2022,has spread rapidly primarily through human-to-human transmission in non-endemic countries(Gong et al.,2022).As of 27 Sep 2023,115 countries and regions have reported cases of mpox to the World Health Organization(WHO),bringing the total number of confirmed cases to 90,618 including 125 *** the number of new cases has decreased in most WHO regions in the second half of 2022,the curves reveal a long outbreak tail in different subregions of the *** worrying,106 mpox cases were reported in the mainland of china in June 2023.

关键词： mainland bringing

Fat necrosis of liver in a patient with mixed type liver cirrhosis

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Hepatobiliary & Pancreatic diseases International 2024年第5期23卷 535-537页

作者： Li-Fang Shao Xiao-Min Shen Wei Yu Department of Nursing the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of infectious diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor: Fatty liver diseases, including nonalcoholic fatty liver disease and alcohol related fatty liver disease, have become a major public health concern [ 1, 2 ]. Fatty liver diseases have been shown to progress through various stages, from steatosis or necrosis with inflammation and hepatocyte damage to the development of fibrosis and eventual cirrhosis with an increased risk of carcinoma [ 2, 3 ].

关键词： cirrhosis diseases liver

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of infectious diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Identification of novel mammalian viruses in tree shrews(Tupaia belangeri chinensis)

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Zoological research 2024年第2期45卷 429-438页

作者： Hong Zhou Ren-Rong Tian Xiu-Rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-Liang Zhao Xu-Dong Zhang Yu-Hua Ma Long-Bao Lv Edward CHolmes Yong-Tang Zheng Wei-Feng Shi School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China Key Laboratory of Emerging infectious diseases in Universities of Shandong Shandong First Medical University and Shandong Academy of Medical SciencesTaianShandong 271000China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China National Resource center for Non-Human Primates Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Sydney Institute for infectious diseases School of Medical SciencesThe University of SydneySydneyNew South Wales 2006Australia Department of infectious diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Virology Shanghai Jiao Tong University School of MedicineShanghai 200025China

The Chinese tree shrew(Tupaia belangeri chinensis),a member of the mammalian order Scandentia,exhibits considerable similarities with primates,including humans,in aspects of its nervous,immune,and metabolic *** similarities have established the tree shrew as a promising experimental model for biomedical research on cancer,infectious diseases,metabolic disorders,and mental health ***,we used metatranscriptomic sequencing to analyze plasma,as well as oral and anal swab samples,from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic *** total,eight mammalian viruses with complete genomes were identified,belonging to six viral families,including Flaviviridae,Hepeviridae,Parvovirinae,Picornaviridae,Sedoreoviridae,and ***,the presence of rotavirus was recorded in tree shrews for the first *** viruses-hepacivirus 1,parvovirus,and picornavirus-exhibited low genetic similarity(94%)to known viral *** analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel *** findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews,highlighting the necessity for further research into their potential for crossspecies transmission.

关键词： Tree shrew(Tupaia belangeri chinensis) Meta-transcriptomic sequencing Mammalian viruses Genomic analysis

Current epidemiologic features and health dynamics of ESBL-producing Escherichia coli in china

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Biosafety and Health 2024年第1期6卷 40-49页

作者： Sayed Salman Zeeshan Umar Yonghong Xiao Collaborative Innovation center for Diagnosis and Treatment of infectious diseases State Key Laboratory for Diagnosis and Treatment of Infectious Diseasesthe First Afiliated Hospital College of MedicineZhejiang UniversityHangzhou 310000China Marshall Laboratory of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 510000China

Extended‐spectrumβ‐lactamase(ESBL)‐producing Escherichia coli(***)are widespread in china,with occurrences documented in humans,animals,and the *** dissemination of ESBL‐producing *** is likely facilitated by the widespread use of antibiotics in human and animal agriculture,the presence of antibiotic‐resistant bacteria(ARBs)in animal feces,and close human‐animal ***,particularly those belonging to incompatibility(Inc)group,such as IncF,IncI,and IncH families,play a vital role in facilitating the horizontal gene transfer of ESBL genes across various sectors,from humans to animals and the *** 26 and IS 1 elements also significantly influences the mobilization and evolution of antibiotic‐resistance genes(ARGs),contributing to the spread of ESBL‐producing ***‐M-14,blaCTX-15,and blaCTX‐M-55 are prevalent in ESBL‐producing *** across the three domains and are often found in con-junction with other *** these challenges,it is imperative to take proactive measures to prevent the further spread of *** includes the judicious and responsible use of antibiotics and efforts to mini-mize contact with animal ***‐specific strategies should be developed to effectively educate and engage relevant personnel in tackling this multifaceted *** efforts are vital to combat the dissem-ination of ESBL‐producing *** and preserve public health.

关键词： Escherichia coli Extended‐spectrumβ‐lactamases CTX‐M

Long noncoding nuclear enriched abundant transcript 12 is a promising biomarker for childhood-onset systemic lupus erythematosus

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儿科学研究(英文) 2024年第2期08卷 101-107页

作者： Li Shipeng Wang Xia Zhao Xiaozhen Deng Jianghong Kuang Weiying Zhang Junmei Tan Xiaohua Li Chao Li Caifeng Department of Rheumatology Beijing Children''s Hospital Capital Medical University National Center for Children’s Health Beijing China center for infectious diseases Beijing Youan Hospital Capital Medical University Beijing Key Laboratory for HIV/AIDS Research Beijing China

Importance: Systemic lupus erythematosus （SLE） is a diffuse connective tissue disease with complex clinical manifestations and prolonged course. The early diagnosis and condition monitoring of SLE are crucial to disease ***: To assess the diagnostic value of long noncoding RNA （lncRNA） nuclear enriched abundant transcript 1 （NEAT1） in childhood-onset SLE （cSLE）.Methods: Fifty-seven children diagnosed with SLE, 40 children diagnosed with juvenile idiopathic arthritis （JIA）, and 40 healthy children were included. Peripheral blood samples from each patient were collected. A quantitative polymerase chain reaction was used to confirm the expression of lncNEAT11and lncNEAT12in peripheral blood. Associations among parameters were analyzed using the Mann-WhitneyU test or independent ***: The expression of both lncNEAT11and lncNEAT12in patients with cSLE were significantly higher than that of healthy control and patients with JIA. Receiver operating characteristic curves revealed an area under the curve （AUC） of 0.633 （95% confidence interval [CI], 0.524-0.742;P = 0.024） for lncNEAT11. The AUC of lncNEAT12was 0.812 （95% CI, 0.727-0.897;P < 0.0001） to discriminate individuals with cSLE from health control and children with JIA with a sensitivity of 0.622 and a specificity of 0.925. Moreover, lncNEAT12expression was higher in patients with cSLE presenting with fever, lupus nephritis, elevated erythrocyte sedimentation rate, active disease activity, and decreased C3 level, compared with those without these conditions. However, no similar correlation was observed for ***: The expression of lncNEAT12was significantly elevated in children with SLE, especially those with fever, renal involvement, and low C3 levels. These findings suggest that lncNEAT12may represent a potential biomarker for cSLE.

关键词： Biomarker Children LncRNA SLE NEAT1

Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis

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Biosafety and Health 2024年第3期6卷 133-142页

作者： Jin Sun Xiaoxu Han Hongxia Yan Xin Zhang Taiyi Jiang Tong Zhang Hao Wu Grigory Kaminskiy Yingmin Ma Eduard Karamov Bin Su Bejing Key Laboratory for HIV/AIDS research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBejing 100069China State Health Organization Tula Regional center for Control and Prevention of AIDS and infectious diseases Tula 300002Russia Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBejing 100069China Gamaleya National research Centre for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation Moscow 123098Russia

The high morbidity and mortality rate of individuals with human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)coinfected with Mycobacterium tuberculosis(MTB)is a tough challenge for current global tuberculosis prevention and control ***/MTB coinfection is more complex than a single infection,and the interaction between the two diseases aggravates the deterioration caused by the disease,resulting in increased hospitalizations and *** screening and early diagnosis facilitate the timely initiation of anti-tuberculosis treatment in HIV/MTB coinfected individuals,thereby reducing transmission and the incidence of adverse *** date,pathogenic detection has remained the gold standard for diagnosing tuberculosis,but its sensitivity and specificity are greatly affected by the body's immune status,which limits its application in the diagnosis of HIV/MTB ***,immunology and molecular detection technology has developed *** detection technologies,such as interferon-release assays,interferon-gamma inducible protein 10,and GeneXpert MTB/RIF assay have overcome the limitations of traditional detection methods,significantly improved the sensitivity and specificity of tuberculosis diagnosis,and brought new hope to the detection of HIV/MTB *** this article,the principle,scope of application,and latest research progress of relevant detection methods are reviewed to provide a reference for the early diagnosis of HIV/MTB coinfection.

关键词： Human immunodeficiencyvirus(HIV) Mycobacteriumtuberculosis(MTB)coinfection Mycobacterium tuberculosis(MTB) Earlydiagnosis