检索结果-南通市图书馆

The expanding amyloid family:Structure,stability,function,and pathogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第1期46卷 106-106页

作者： Michael R Sawaya departments of chemistry and Biochemistry and Biological chemistry UCLA Los Angeles CA 90095 USA Laboratory of Physical chemistry ETH Zurich Vladimir Prelog Weg 2 CH-8093 Zurich Switzerland

The hidden world of amyloid biology has suddenly snapped into atomic-level focus,revealing over 80 amyloid protein fibrils,both pathogenic and *** globular proteins,amyloid proteins flatten and stack into unbranched *** still,a single protein sequence can adopt wildly different two-dimensional conformations,yielding distinct fibril polymorphs.

关键词： amyloid pathogenesis expanding

Constructing extrinsic oxygen vacancy on the surface of photocatalyst as CO_(2)and electrons reservoirs to improve photocatalytic CO_(2)reduction activity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第6期140卷 37-45页

作者： Zaiyong Jiang Hao Li Zhimin Yuan Zheng Wang Maohong Fan Wenkang Miao Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of chemistry&Chemical Engineering and Environmental Engineering Weifang UniversityWeifangShandong 261061China departments of Chemical and Petroleum Engineering University of WyomingLaramieWY 82071USA Materials Genome Institute Shanghai UniversityShanghai 200444China

Constructing own oxygen vacancies in the photocatalysts is a very promising method to improve their photocatalytic CO_(2)reduction ***,some catalysts have excellent stabilities,making it difficult for them to construct their own oxygen *** simplify the above difficulty of stable photocatalysts,constructing extrinsic oxygen vacancies on their surface as a novel idea is ***,a stable TiO_(2)nanosheet is chosen as a research object,we uniformly deposited BiOCl quantum dots on their surface via a simple adsorption-deposition *** is found that BiOCl quantum dots are able to simultaneously self-transform into defective BiOCl with many oxygen vacancies when the photocatalyst is performed photocatalytic CO_(2)*** extrinsic oxygen vacancies can act as“CO_(2)and photo-generated electrons reservoirs”to improve CO_(2)capture and accelerate the separation of photogenerated electrons and *** the above reasons,the modified TiO_(2)showed obvious enhancement of photocatalytic CO_(2)reduction compared to pristine TiO_(2)and *** work may open a new avenue to broaden the use of oxygen vacancies in the process of photocatalytic CO_(2)reduction.

关键词： Oxygen vacancy BiOCl Photocatalyst CO_(2)reduction TiO_(2)

Bioactive compounds in Hericium erinaceus and their biological properties:a review

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang College of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech Co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA departments of chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

A systematic understanding of microbial reductive dechlorination towards an improved “one health” soil bioremediation: A review and perspective

在线全文

学校读者我要写书评

暂无评论

Science China Technological Sciences 2024年

作者： HE Yan LI ShuYao YUAN Jing CHENG Jie DOU JiBo YANG XueLing XU JianMing Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource Sciences Zhejiang University Key Laboratory of Environment Remediation and Ecological Health Ministry of Education Microbiome Network and Department of Agricultural Biology Colorado State University departments of chemistry and Chemical & Biomolecular Engineering Institute for Functional Intelligent Materials (I-FIM)National University of Singapore

Chlorinated organic pollutants(COPs), both emerging and traditional, are typical persistent pollutants that harm soil health worldwide. Dechlorinators mediated reductive dechlorination is the optimal way to completely remove COPs from anaerobic soil through a redox reaction driven by electron transfer during microbial anaerobic respiration. Generally, the dechlorinated depletion of COPs in situ often interacts with multiple element biogeochemical activities, e.g., methanogenesis, sulfate reduction, iron reduction, and denitrification. Elucidating the relevance of biogeochemical cycles between COPs and multiple elements and the coupled mechanisms involved, thus, helps to develop effective pollution control strategies with the balance between pollution degradation and element cycles in heterogeneous soil, ultimately contributing to “one health” goal. In this review, we summarized the microbial-chemical coupling redox processes and the driving factors, elucidated the interspecies metabolites exchange and electron transfer mechanisms within COP-dechlorinating communities, and further proposed a detailed design, construction, and analysis framework of engineering COP-dechlorinating microbiomes via “top-down” selfassembly and “bottom-up” synthesis to pave the way from laboratory to practical field application. Especially, we delve into the major challenges and perspectives surrounding the design of state-of-the-art synthetic microbial communities. Our goal is to improve the understanding of the microbial-mediated coupling between reductive dechlorination and element biogeochemical cycling, with a particular focus on the implications for health-integrated soil bioremediation under the “one health” concept.

关键词：

Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

Understanding protein palmitoylation:Biological significance and enzymology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China chemistry 2011年第12期54卷 1888-1897页

作者： FIERKE Carol A. departments of chemistry and Biological chemistry University of Michigan930 N University

Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl *** lipid modification is readily reversible;a feature of protein palmitoylation that allows for rapid regulation of the function of many cellular *** in palmitoyltransferases(PATs),the enzymes that catalyze the formation of this modification,are associated with a number of neurological diseases and cancer *** review summarizes the crucial role of palmitoylation in biological systems,the discovery of the DHHC protein family that catalyzes protein palmitoylation,and the development of methods for investigating the catalytic mechanism of PATs.

关键词：蛋白质生物学意义棕榈酶学神经系统疾病半胱氨酸快速调节生物系统

Batteries for wearables

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第1期10卷 9-11页

作者： Lie Wang Ye Zhang Peter G.Bruce National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center (Chem BIC) Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University departments of Materials and chemistry University of Oxford

Batteries that convert the stored chemical energy directly into electricity have been known for hundreds of *** the lithium-ion battery as representative because of its high energy-conversion efficiency and long cycle *** is widely used as a power accessory for electronic devices and has become an important part of modern electronics.

关键词：

Thoughts on air quality when the world is electrified

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 138-138页

作者： Ronald C.Cohen departments of chemistry and of Earth andPlanetary Science University of California

We still live in a fossil-fuel-dominated world. Today, poor air quality is almost always associated with leaks of fuel into the atmosphere and unwanted byproducts of their combustion. However, a future where fossil fuels are replaced almost entirely with clean electricity is not far *** the worst possible outcomes of climate change demands that we create that world.

关键词：

Over 9% efficiency achieved for all-polymer solar cells processed by a green solvent

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China chemistry 2017年第8期60卷 1109-1110页

作者： Guillermo C.Bazan departments of chemistry & Biochemistry and Materials University of California Santa Barbara

Bulk-heterojunction polymer solar cells(PSCs)have attracted considerable attention owning to their potential for fabricating flexible,light-weight and large area solar cell panels via high-throughput roll-to-roll *** with conventional PSCs comprising small molecule acceptors,such as fullerenes,all-polymer solar cells(all-PSCs)containing blends of p-type/n-type polymers in the photoactive layer provide advantages including

关键词： PSCs on in is for efficiency achieved for all-polymer solar cells processed by a green solvent Over 9 by