Understanding protein palmitoylation:Biological significance and enzymology

作     者：FIERKE Carol A. 

作者机构：Departments of Chemistry and Biological ChemistryUniversity of Michigan930 N University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2011年第54卷第12期

页      面：1888-1897页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by the NIH R01 grant GM040602 (CAF) 

主　　题：蛋白质 生物学意义 棕榈 酶学 神经系统疾病 半胱氨酸 快速调节 生物系统 

摘      要：Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl *** lipid modification is readily reversible;a feature of protein palmitoylation that allows for rapid regulation of the function of many cellular *** in palmitoyltransferases(PATs),the enzymes that catalyze the formation of this modification,are associated with a number of neurological diseases and cancer *** review summarizes the crucial role of palmitoylation in biological systems,the discovery of the DHHC protein family that catalyzes protein palmitoylation,and the development of methods for investigating the catalytic mechanism of PATs.