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Efficacy and safety of high-dose ultrasound cyclo-plasty procedure in refractory glaucoma

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1391-1396页

作者： He-Ting Liu Qing Zhang Zheng-Xuan Jiang Yu-Xin Xu Qian-Qian Wan Li-Ming Tao Department of Ophthalmology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

AIM:To evaluate the efficacy and safety of high-dose ultrasound cyclo-plasty(UCP)for the treatment of refractory glaucoma in Chinese ***:In this 6-month retrospective study,37 eyes of 37 patients suffering from severe glaucoma with uncontrolled intraocular pressure(IOP)of≥21 mm Hg underwent 8-s ultrasonic cyclocoagulation with ten active piezoelectric elements.A complete ophthalmic examination was performed before and at 1 d,1,3,6 mo after *** success was defined as IOP reduction from baseline≥20%and IOP≥5 mm Hg without adding new glaucoma medication compare to baseline at the 6-month follow-up *** addition to mean IOP at each followup visit,medications used and complications were also detected and compared to ***:After UCP procedure,the mean IOP was significantly reduced(P<0.01)from the preoperative 44.1±11.9 mm Hgto postoperative 26.7±11.8 mm Hg at 3 mo,and 30.4±14.5 mm Hg at 6 *** overall mean IOP reductions achieved at 3 and 6 mo were 39%and 31%compared to baseline ***-one percent of patients responded well to UCP treatment with a mean IOP reduction of 48%at 3 mo and 42%at 6 *** pain in most of patients were *** serious intraoperative or postoperative complications ***:High-dose UCP treatment is an effective and safe procedure to reduce IOP in Chinese patients with severe glaucoma.

关键词： ultrasound cyclo-plasty cyclodestruction intraocular pressure reduction glaucoma

Primary hyperparathyroidism in a woman with multiple tumors: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3132-3137页

作者： Can-Can Hui Xue Zhang Jian-Ran Sun Da-Tong Deng Department of Endocrinology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Endocrinology The First Affiliated Hospital of USTC Anhui Provincial HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Parathyroid adenoma(PTA)is known as an adenomatous hyperparathyroidism *** earlier times,the major symptoms of this disease included high blood calcium and low *** is a benign neuroendocrine *** have reviewed the literature and found that it is rare for patients with hyperparathyroidism to have benign tumors with multiple organs at the same *** report describes a patient with a PTA and four nonfunctional *** SUMMARY We report a case of primary hyperparathyroidism in a 39-year-old woman with multiple organ *** patient was admitted to hospital because of ***,imaging,and histological examinations confirmed a left parathyroid *** thyroid adenoma was discovered during *** had a medical history of uterine fibroids,right benign mammary gland tumor,and *** patient recovered after surgical and conservative *** Primary hyperparathyroidism with multiple organ tumors is uncommon,and further studies should be conducted to determine if there is genetic heterogeneity.

关键词： Primary hyperparathyroidism Parathyroid neoplasm Thyroid adenoma Meningioma Breast neoplasm Case report

Malignant transformation of primary mature teratoma of colon:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7076-7081页

作者： Jie Liu Department of Pathology The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Mature teratoma is a common benign ovarian germ cell tumor,accounting for about 20%of ovarian *** malignant transformation of this tumor is less than 2%.The most common type is squamous cell carcinoma,followed by *** transformation of colonic mature teratoma is extremely *** here report a case of malignant transformation of primary mature teratoma of the *** type of malignant transformation was *** SUMMARY A 63-year-old woman was admitted to our hospital due to persistent pain in her right lower abdomen for 1 mo,and she had no nausea,vomiting,blood in the stools,or other *** colonoscopy showed uplift of the sigmoid colon mucosa and *** biopsy showed squamous ***,contrast-enhanced computed tomography of abdomen and pelvis showed a localized thickening of the sigmoid wall,suggesting colon *** ultrasonography(EUS)revealed that the structure of the intestinal wall at the base of the lesion was destroyed,and the boundary between the lesion and the surroundings was *** to the findings of the EUS,the patient did not undergo endoscopic submucosal dissection,but underwent radical resection of the ***,squamous epithelium was seen on the mucosal surface of the colon wall,cartilage and glands were seen under the epithelium,and adenocarcinoma was seen on the muscular layer and serous *** final pathological diagnosis was malignant teratoma of the *** have followed up the patient for 2 mo since the operation,and the patient recovered *** This case suggests the possibility of mature teratoma in the colon and recognition of malignant types,and it should not be considered as an exclusively ovarian tumor.

关键词： Colon Mature teratoma Malignant transformation Adenocarcinoma Squamous epithelium Case report

Clinical characteristics of testicular torsion and factors influencing testicular salvage in children:A 12-year study in tertiary center

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World Journal of Clinical Cases 2024年第7期12卷 1251-1259页

作者： Xiang-Hui Gang Yuan-Yuan Duan Bin Zhang Zheng-Gan Jiang Rong Zhang Jun Chen Xiang-Yu Teng Duo-Bing Zhang Department of Urology Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Ultrasound Diagnosis Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Urology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Testicular torsion is the most common acute scrotum worldwide and mainly occurs in children and *** have demonstrated that the duration of symptoms and torsion grade lead to different outcomes in children diagnosed with testicular *** To predict the possibility of testicular salvage(TS)in patients with testicular torsion in a tertiary *** We reviewed the charts of 75 pediatric patients with acute testicular torsion during a 12-year period from November 2011 to July 2023 at the Suzhou hospital of anhui medical *** and multivariate logistic regression analyses were used to determine independent predictors of testicular *** data included clinical findings,physical examinations,laboratory data,color Doppler ultrasound findings,operating results,age,presenting institution status,and follow-up *** Our study included 75 *** was possible in 57.3%of all patients;testicular torsion occurred mostly in winter,and teenagers aged 11-15 years old accounted for 60%.Univariate logistic regression analyses revealed that younger age(P=0.09),body mass index(P=0.004),torsion angle(P=0.013),red blood cell count(P=0.03),neutrophil-to-lymphocyte ratio(P=0.009),and initial presenting institution(Phospital as soon as possible.

关键词： Testicular torsion Testicular salvage Pediatrics Predictors Case report

Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study

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World Journal of Gastroenterology 2022年第37期28卷 5469-5482页

作者： Dong Jiang Zi-Xiang Chen Fu-Xiao Ma Yu-Yong Gong Tian Pu Jiang-Ming Chen Xue-Qian Liu Yi-Jun Zhao Kun Xie Hui Hou Cheng Wang Xiao-Ping Geng Fu-Bao Liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina

BACKGROUND Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms(PCNs)are *** To establish a nomogram-based online calculator for predicting the risk of malignancy in patients with *** In this study,the clinicopathological data of target patients in three medical centers were *** independent sample t-test,Mann–Whitney U test or chi-squared test were used as appropriate for statistical *** univariable and multivariable logistic regression analysis,five independent factors were screened and incorporated to develop a calculator for predicting the risk of ***,the concordance index(C-index),calibration,area under the curve,decision curve analysis and clinical impact curves were used to evaluate the performance of the *** Enhanced mural nodules[odds ratio(OR):4.314;95%confidence interval(CI):1.618–11.503,P=0.003],tumor diameter≥40 mm(OR:3.514;95%CI:1.138–10.849,P=0.029),main pancreatic duct dilatation(OR:3.267;95%CI:1.230–8.678,P=0.018),preoperative neutrophil-to-lymphocyte ratio≥2.288(OR:2.702;95%CI:1.008–7.244,P=0.048],and preoperative serum CA19-9 concentration≥34 U/mL(OR:3.267;95%CI:1.274–13.007,P=0.018)were independent risk factors for a high risk of malignancy in patients with *** the training cohort,the nomogram achieved a C-index of 0.824 for predicting the risk of *** predictive ability of the model was then validated in an external cohort(C-index:0.893).Compared with the risk factors identified in the relevant guidelines,the current model showed better predictive performance and clinical *** The calculator demonstrates optimal predictive performance for identifying the risk of malignancy,potentially yielding a personalized method for patient selection and decision-making in clinical practice.

关键词： Pancreatic cystic neoplasms Risk of malignancy Nomogram Model Prediction Calculator

Immune cells in alcohol-related liver disease

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Liver Research 2022年第1期6卷 1-9页

作者： Honghai Xu Hua Wang Department of Pathology the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Inflammation and Immune Mediated Diseases Laboratory of anhui Province Anhui Medical UniversityHefeiAnhuiChina

Alcohol-related liver disease(ALD),which is caused by excessive alcohol consumption,is one of the most common types of liver disease and a primary cause of hepatic injury,with a disease spectrum that in-cludes steatosis,steatohepatitis,fibrosis,cirrhosis,and hepatocellular *** lines of evi-dence have indicated that immune cells play a significant role in the inflammatory processes of *** the one hand,the liver contains various resident immune cells that have been proven to perform different functions in *** example,in the progression of the disease,Kupffer cells(KCs)are activated by lipopolysaccharide-Toll-like receptor 4 signaling and release various proinflammatory ***,alcohol intake has been shown to depress the function of natural killer ***,two types of unconventional T cells(natural killer T cells and mucosal-associated invariant T cells)are involved in the development of *** the other hand,alcohol and many different cytokines stimulate the recruitment and infiltration of circulating immune cells(neutrophils,T cells,macrophages,and mast cells)into the *** neutrophils can produce proinflammatory mediators and cause the dysfunction of anti-infection ***,alcohol intake can change the phenotype of T cells,resulting in their increased production of *** from KCs,infiltrating macrophages have also been observed in patients with ALD,but the roles of all of these cells in the progression of the disease have shown both similarities and ***,the activated mast cells are also associated with the development of ***,we review the diverse roles of the various immune cells in the progression of ALD.

关键词： Alcohol-related liver disease(ALD) Resident immune cells Circulating immune cells Infiltrating immune cells Inflammation Cytokines

Rigid esophagoscopy combined with angle endoscopy for treatment of superior mediastinal foreign bodies penetrating into the esophagus caused by neck trauma: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4130-4136页

作者： Dong Wang Chao-Bing Gao Department of Otorhinolaryngology Head and Neck First Affiliated Hospital of Anhui Medical University

BACKGROUND Herein,we report a case in whom two foreign bodies entered the upper mediastinal cavity from the cervical root and subsequently the *** is the preferred treatment method,and operational procedures depend on the size and location of the foreign body relative to the mediastinal *** esophagoscopy combined with angle endoscopic surgery was selected to avoid surgical trauma and *** SUMMARY A 63-year-old male patient with a 6-mo old history of neck trauma presented with a black-brown foreign body in the lateral wall of the *** and chest computed tomography(CT)revealed that two superior mediastinal foreign bodies penetrated the esophagus *** removed two foreign bodies through an *** to the rigid working channel of esophagoscope and good exposure of endoscope,the risk of injury to the adjacent vital tissues was *** comprehensive therapies,including antibiotic administration and nutritional support,resulted in a prompt postoperative *** CT confirmed the absence of a residual foreign body and neck and chest *** addition,upper gastrointestinal angiography and gastroscopy revealed the absence of an evident esophageal *** patient received an oral diet and did not experience any complication at the time of discharge from the *** Rigid esophagoscopy combined with angle endoscopy is an effective,minimally invasive treatment for penetrating neck injuries.

关键词： Superior mediastinal Esophagoscope Esophageal perforation Case report

Clinical online nomogram for predicting prognosis in recurrent hepatolithiasis after biliary surgery:A multicenter,retrospective study

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World Journal of Gastroenterology 2022年第7期28卷 715-731页

作者： Tian Pu Jiang-Ming Chen Zi-Han Li Dong Jiang Qi Guo Ang-Qing Li Ming Cai Zi-Xiang Chen Kun Xie Yi-Jun Zhao Cheng Wang Hui Hou Zheng Lu Xiao-Ping Geng Fu-Bao Liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of the University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina

BACKGROUND Methods for predicting the prognosis of patients undergoing surgery for recurrent hepatolithiasis after biliary surgery are currently *** To establish a nomogram to predict the prognosis of patients with recurrent hepatolithiasis after biliary *** In this multicenter,retrospective study,data of consecutive patients in four large medical centers who underwent surgery for recurrent hepatolithiasis after biliary surgery were retrospectively *** constructed a nomogram to predict the prognosis of recurrent hepatolithiasis in a training cohort of 299 patients,following which we independently tested the nomogram in an external validation cohort of 142 ***,we used the concordance index(C-index),calibration,area under curve,decision curve analysis,clinical impact curves,and visual fit indices to evaluate the accuracy of the *** Multiple previous surgeries[2 surgeries:Odds ratio(95%confidence interval),1.451(0.719-2.932);3 surgeries:4.573(2.015-10.378);≥4 surgeries:5.741(1.347-24.470)],bilateral hepatolithiasis[1.965(1.039-3.717)],absence of immediate clearance[2.398(1.304-4.409)],neutrophil-to-lymphocyte ratio≥2.462[1.915(1.099-3.337)],and albumin-to-globulin ratio≤1.5[1.949(1.056-3.595)]were found to be independent factors influencing the *** nomogram constructed on the basis of these variables showed good reliability in the training(C-index:0.748)and validation(C-index:0.743)*** with predictions using traditional classification models,those using our nomogram showed better agreement with actual observations in the calibration curve for the probability of endpoints and the receiver operating characteristic *** and clinical impact curves showed a larger net benefit of the *** The nomogram developed in this study demonstrated superior performance and discriminative power compared to the three traditional *** is easy to use,highly accurate,an

关键词： Gallstones Reoperation Risk factors Nomogram Prognosis Model

METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： Ling-Shang Kong Ran Tao Yi-Fan Li Wen-Bin Wang Xue Zhao Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina Department of Scientific Research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina Department of Scientific Research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various ***,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains *** To investigate the role of METTL5 in *** We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell *** elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream *** vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and *** Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable *** vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and ***,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor *** The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer