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Neuroprotective effects of Shaoyao Gancao decoction against excitatory damage in PC12 cells based on the Src-NR2-nNOS pathway

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 293-302页

作者： Xiaoxu Fan Hongyan Ma Tiantian Zhou Min Fu Zhiyuan Qiao Yingtong Feng Zhen Wang Yiwei Shen Jingxia Wang School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese medicine Xinjiang Medical UniversityUrumqi 830017China The centre for Translational Biology Research Institute of McGill University Health CentreMontréal H4A 3J1Canada

Objective To explore the neuroprotective effects of the Shaoyao Gancao decoction(SGD)against excitatory damage in PC12 cells and the role of the Src-NR2-nNOS pathway mediation by SGD in regulatingγ-aminobutyric acid(GABA)-glutamate(Glu)*** N-Methyl-d-aspartic acid(NMDA)was used to establish a PC12 cell excitability injury *** investigate the neuroprotective effect of SGD,a cell counting kit-8(CCK-8)assay was used to determine PC12 cell viability,Annexin V/Propidium Iodide(Annexin V/PI)double staining was used to determine PC12 cell apoptosis,and Ca^(2+)concentration was observed using laser confocal *** receptor agonists and antagonists were used to analyze the neuroprotective interactions betweenγ-aminobutyric acid(GABA)and NMDA ***,molecular biology techniques were used to determine mRNA and protein expression in the Src-NR2-nNOS *** analyzed the correlations between the regulatory sites of GABA and NMDA interactions,excitatory neurotoxicity,and brain damage at the molecular *** NMDA excitotoxic injury manifested as a significant decrease in cell activity,increased apoptosis and caspase-3 protein expression,and a significant increase in intracellular Ca^(2+)*** of SGD,a GABAA receptor agonist(muscimol),or a GABAB receptor agonist(baclofen)decreased intracellular Ca^(2+)concentrations,attenuated apoptosis,and reversed NMDA-induced upregulation of caspase-3,Src,NMDAR2A,NMDAR2B,and ***,a GABA_(A)receptor antagonist(bicuculline)and a GABA_(B)receptor antagonist(saclofen)failed to significantly increase excitatory *** Taken together,these results not only provide an experimental basis for SGD administration in the clinical treatment of central nervous system injury diseases,but also suggest that the Src-NR2A-nNOS pathway may be a valuable target in excitotoxicity treatment.

关键词： Shaoyao Gancao decoction PC12 N-Methyl-D-aspartic acid(NMDA) γ-aminobutyric acid(GABA) Src nNOs

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Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology,molecular docking,and in vitro experiments

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 55-66页

作者： Shuangqiao Liu Xin Liu Sijia Jiang Min Fu Jinxi Hu Jiaqi Liu Xiaoxu Fan Yingtong Feng Shujing Zhang Jingxia Wang School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese medicine Xinjiang Medical UniversityUrumqi 830017China The centre for Translational Biology Research Institute of McGill University Health CentreMontr eal H4A 3J1Canada

Objective:To explore and validate the potential targets of Paeoniae Radix Alba(***,Bai Shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell ***:Network pharmacology was used to identify the common potential targets of *** and chemical liver *** docking was used to fit the components,which were subsequently verified in vitro.A cell model of hepatic fibrosis was established by activating hepatic stellate cell(HSC)-LX2 cells with 10 ng/mL transforming growth factor-β*** cells were exposed to different concentrations of total glucosides of paeony(TGP),the active substance of ***,and then evaluated using the cell counting kit-8 assay,enzyme-linked immunosorbent assay,and western ***:Analysis through network pharmacology revealed 13 key compounds of ***,and the potential targets for preventing chemical liver injury were IL-6,AKT serine/threonine kinase 1,jun protooncogene,heat shock protein 90 alpha family class A member 1(HSP90AA1),peroxisome proliferator activated receptor gamma(PPARG),PTGS2,and *** Ontology(GO)enrichment analysis indicated the involvement of response to drugs,membrane rafts,and peptide *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis revealed that the main pathways involved lipid and atherosclerosis and chemical carcinogenesis-receptor *** and albiflorin exhibited strong affinity for HSP90AA1,PTGS2,PPARG,and *** concentrations of TGP can inhibit the expression of COL-I,COL-III,IL-6,TNF-a,IL-1β,HSP-90a,and PTGS2 while increasing the expression of PPAR-γand CASP3 in activated HSC-LX2 ***:*** primarily can regulate targets such as HSP90AA1,PTGS2,PPARG,***,the main active compound of ***,protects against chemical liver injury by reducing the inflammatory response,activating apoptotic proteins,and promoting the apoptosis of activated HSCs.

关键词： Paeoniae Radix Alba Total glycosides of paeony Chemical liver injury Liver fibrosis Network pharmacology Hepatic stellate cells

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Co-enhancement of thermal conduction and radiation through morphologies controlling of graphene functional layer for chip thermal management

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Nano Research 2024年第10期17卷 8885-8892页

作者： Shuting Cheng Kun Wang Shichen Xu Yi Cheng Ruojuan Liu Kewen Huang Hao Yuan Wenjuan Li Yuyao Yang Fushun Liang Fan Yang Kangyi Zheng Zhiwei Liang Ce Tu Mengxiong Liu Xiaomin Yang Jingnan Wang Xuzhao Gai Yuejie Zhao Xiaobai Wang Yue Qi Zhongfan Liu State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China centre for Nanochemistry Beijing Science and Engineering Centre for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute(BGI) Beijing 100095China College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhou 215006China Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China

With the continuous advancements in electronics towards downsizing and integration,efficient thermal dissipation from chips has emerged as a critical factor affecting their lifespan and operational *** fan-less chip cooling system has two critical interfaces for thermal transport,which are the contact interface between the base and the chip dominated by thermal conduction,and the surface of the fins dominated by thermal *** different thermal transfer modes of these two critical interfaces pose different requirements for thermal management *** the study,a novel approach was proposed by developing graphene thermal transport functional material whose morphology could be intentionally designed via reformed plasmaenhanced chemical vapor deposition(PECVD)methods to meet the diverse requirements of heat transfer ***,graphene with multilevel branching structure of vertical graphene(BVG)was fabricated through the hydrogenassisted PECVD(H_(2)-PECVD)strategy,which contributed a high emissivity of~*** was deposited on the fins’surface and functioned as the radiation enhanced layer to facilitate the rapid radiation of heat from the heat sinks into the surrounding ***,the well-oriented vertical graphene(OVG)was successfully prepared through the vertical electric field-assisted PECVD process(EF-PECVD),which showed a high directional thermal conductivity of~53.5 W·m^(-1)·K^(-1).OVG was deposited on the contact interface and functioned as the thermal conduction enhanced layer,allowing for the quick transmission of heat from the chip to the heat *** this design concept,the two critical interfaces in the chip cooling system can be jointly enhanced,resulting in a remarkable cooling efficiency enhancement of~30.7%,demonstrating that this novel material possessed enormous potential for enhancing the performance of cooling ***,this research not only provided new design concepts for the cooling system

关键词： chip thermal management thermal conduction thermal radiation graphene morphology control

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Alginate nanobeads interspersed fibrin network as in situ forming hydrogel for soft tissue engineering

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Bioactive Materials 2018年第2期3卷 194-200页

作者： S.Deepthi R.Jayakumar centre for nanosciences and molecular medicine Amrita UniversityKochi682041India

Hydrogels are a class of materials that has the property of injectability and in situ gel *** property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin *** nanobeads developed by calcium cross-linking yielded a size of 200e500 *** alginate nanobeads fibrin hydrogel was formed using dual syringe *** of the in situ injectable hydrogel was done by SEM,FTIR and *** developed hydrogel showed mechanical strength of 19 kPa which provides the suitable compliance for soft tissue *** studies using human umbilical cord blood derived mesenchymal stem cells showed good attachment,proliferation and infiltration within the hydrogel similar to fibrin *** developed in situ forming hydrogel could be a suitable delivery carrier of stem cells for soft tissue regeneration.

关键词： Alginate nanobeads Fibrin hydrogel Soft tissue engineering

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Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3798-3819页

作者： Matteo Micucci Bian-Zhao Xiang Chen-Min Ting Hiu-Yee Kwan Michele Mari Michele Retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli Department of Biomolecular Sciences University of Urbino Carlo BoUrbino 61029Italy Hong Kong Chinese medicine Clinical Study centre Chinese EQUATOR CentreSchool of Chinese MedicineChinese Clinical Trial Registry(Hong Kong)Hong Kong Baptist UniversityHong Kong 999077China centre for Chinese Herbal medicine Drug Development Hong Kong Baptist UniversityHong Kong 999077China centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Department of Chemistry College of ScienceSalahaddin University-ErbilErbil 44001Iraq Department of Pharmacognosy Faculty PharmacyTishk International UniversityErbil 44001Iraq Institute of Oncology Research Bellinzona CH6500Switzerland Universitàdella Svizzera Italiana Lugano CH6900Switzerland

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and *** review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer *** advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical *** on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated *** agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive *** convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health *** approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease *** combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关键词： Traditional Chinese medicine Precision medicine molecular network Phytochemistry Food chemistry Nutraceuticals Gastric cancer

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Molecule configurations modulate packing array and charge transfer in cocrystal engineering

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Science China Chemistry 2024年第2期67卷 512-516页

作者： Shenglong An Mengyuan Qiao Xin Jin Xuanying Chen Jianhua Su Lifang Guo Zhiyun Zhang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and molecular Engineering Feringa Nobel Prize Scientist Joint Research CentreFrontiers Science Center for Materiobiology and Dynamic ChemistryEast China University of Science&TechnologyShanghai200237China

Organic cocrystal as an emerging assembly strategy has received increasing attention in constructing multiple functional materials,through continually screening suitable constituent monomers or changing their stoichiometry ***,the role of molecule configuration in the cocrystal field is rarely explored despite the fascinating potential in regulating the packing *** this study,the N,N′-diphenyl-5,10-dihydrophenazine derivatives(DPPs) with the flexible scaffold and different methyl substitutions are selected as the donors bearing various molecular *** a simple collaborative way,a series of cocrystals based on DPPs and OFN(octafluoronaphthalene) are fabricated,exhibiting two self-adaptive molecular stacking arrays.X-ray crystallographic analysis and theoretical calculation unveil their different π···π interactions and charge transfer characters,leading to the significant emission redshift up to 125 nm compared with individual *** a result,controllable molecule stacking structure,tunable emission,and charge transfer properties can be *** study provides a new perspective to reveal the structure-property relationships at the molecular level by controlling the molecule configuration in cocrystal engineering,contributing to the development of cocrystal theoretical physics and organic functional materials.

关键词： cocrystals molecular configuration self-adaptive packing mode charge transfer

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Advances in advanced solution-synthesis-based structural materials for tactile sensors and their intelligent applications

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InfoMat 2024年第1期6卷 31-64页

作者： Hongsen Niu Ning Li Eun-Seoung Kim Young Kee Shin Nam-Young Kim Guozhen Shen Yang Li School of Information Science and Engineering University of JinanJinanthe People's Republic of China RFIC centre Department of Electronics EngineeringKwangwoon UniversitySeoulRepublic of Korea Department of molecular medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingthe People's Republic of China School of Microelectronics Shandong UniversityJinanthe People's Republic of China

Intelligent applications,with tactile sensors at their core,represent significant advancement in the field of artificial ***,achieving perception abilities in tactile sensors that match or exceed human skin remains a formidable ***,the design and implementation of hierarchical structural materials are considered the optimal solution to this *** contrast to conventional methods,such as complicated lithography and three-dimensional printing,the cost-effective and scalable nature of advanced solution-synthesis methods makes them ideal for preparing diverse tactile sensors with hierarchical structural ***,the process and applicability of advanced solution synthesis methods have yet to form a seamless ***,the development and intellectualization of tactile sensors based on advanced solution synthesis methods are still in their early stages,and require a comprehensive and systematic review to usher in *** study delves into the advantages and disadvantages of various advanced solution synthesis methods,providing detailed ***,the positive effects of hierarchical structural materials constructed using these methods in tactile sensors and their intelligent applications are also discussed in ***,the challenges and future opportunities faced by this emerging field are summarized.

关键词： aqueous phase reduction artificial intelligence hydrothermal growth in situ polymerization tactile sensor

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WO_(3) passivation layer-coated nanostructured TiO_(2): An efficient defect engineered photoelectrode for dye sensitized solar cell

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Journal of Semiconductors 2021年第5期42卷 91-98页

作者： Arya Babu Arya Vasanth Shantikumar Nair Mariyappan Shanmugam Amrita centre for nanosciences and molecular medicine Amrita Vishwa VidyapeethamKochiKerala-682041India

Major loss factors for photo-generated electrons due to the presence of surface defects in titanium dioxide(Ti O_2)were controlled by RF-sputtered tungsten trioxide(WO_3) passivation. X-ray photoelectron spectroscopy assured the coating of WO3 on the Ti O_2 nanoparticle layer by showing Ti 2 p, W 4 f and O 1 s characteristic peaks and were further confirmed by X-ray diffraction studies. The coating of WO_3 on the Ti O_2 nanoparticle layer did not affect dye adsorption significantly. Dye sensitized solar cells(DSSCs) fabricated using WO_3-coated Ti O_2 showed an enhancement of ~10% compared to DSSCs fabricated using pristine Ti O_2-based photo-electrodes. It is attributed to the WO_3 passivation on Ti O_2 that creates an energy barrier which favored photo-electron injection by tunneling but blocked reverse electron recombination pathways towards holes available in highest occupied molecular orbital of the dye molecules. It was further evidenced that there is an optimum thickness(duration of coating) of WO_3 to improve the DSSC performance and longer duration of WO_3 suppressed photo-electron injection from dye to Ti O_2 as inferred from the detrimental effect in short circuit current density values. RF-sputtering yields pinhole-free,highly uniform and conformal coating of WO_3 onto any area of interest, which can be considered for an effective surface passivation for nanostructured photovoltaic devices.

关键词： charge transport recombination tungsten oxide solar cell interface defects

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Synthesis of Co3O4 Nanoparticles Wrapped Within Full Carbon Matrix as an Anode Material for Lithium Ion Batteries

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 164-170页

作者： Subhalaxmi Mohapatra Shantikumar V.Nair Alok Kumar Rai Amrita centre for nanosciences and molecular medicine Amrita Vishwa Vidyapeetham Amrita University Kochi Kerala 682041 India

A facile polyol-assisted pyro-synthesis method was used to synthesize Co3O4 nanoparticles embedded into carbon matrix without using any conventional carbon source. The surface analysis by scanning electron microscopy showed that the Co3O4 nanoparticles（-20 ± 5 nm） are tightly enwrapped within the carbon matrix. CHN analysis determined the carbon content was only 0.11% in the final annealed sample. The Co3O4@carbon exhibited high capacities and excellent cycling performance as an anode at various current rates（such as 914.4 and 515.5 mAh g^-1 at 0.25 and1.0 C, respectively, after 50 cycles; 318.2 mAh g^-1 at a high current rate of 5.0 C after 25 cycles）. This superior electrochemical performance of the electrode can be attributed to the various aspects, such as,（1） the existence of carbon matrix, which acts as a flexible buffer to accommodate the volume changes during Li^＋ion insertion/deinsertion and facilitates the fast Li^＋and electron transfer and（2） the anchoring of Co3O4 nanoparticles within the carbon matrix prevents particles agglomeration.

关键词： Co3O4 Carbon matrix Pyro-synthesis Anode Lithium ion battery

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Curcumin for gastric cancer:Mechanism prediction via network pharmacology,docking,and in vitro experiments

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui Yang Ya-Nan Wei Bi-Juan Xiao Si-Yi Li Xin-Long Li Liang-Jun Yang Hua-Feng Pan Geng-Xin Chen The Second School of Clinical medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina centre for Translational medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacological approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OMIM,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer Network pharmacology molecular docking Survival analysis

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