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Atherogenic Indices and HDL Particle Size as laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

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Journal of Biophysical Chemistry 2014年第2期5卷 24-32页

作者： Ana Paula C.santos Marcos S.Vieira Debora F.Deus Rogerio Jorge Bde Oliveira Aleksandra T.Morikawa Roque Aras Ajax M.Atta Fabio D.Couto Raul C.Maranhao Ricardo D.Couto clinical Biochemistry laboratory Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Naval hospital of Salvador Brazilian Marine ForcesSalvadorBrazil Lipid Metabolism laboratory of the Heart Institute(InCor-clinical hospital of Medical School) Faculty of PharmacyUniversity of Sao Paulo/USPSao PauloBrazil Ana Neri hospital SESAB and Federal University of Bahia/UFBA Faculty of MedicineSalvadorBrazil laboratory of Research in Immunology(LAPIM) Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences(CCAAB-UFRB)Cruz das AlmasBrazil Faculty of Pharmaceutical Sciences Clinical Chemistry DepartmentUniversity of Sao Paulo/USPSao PauloBrazil central clinical laboratory of professor edgar santos university hospital Federal University of Bahia/UFBASalvadorBrazil

Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p < 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

关键词： Dyslipidemia Atherogenic Indices Cardiovascular Risk

Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents

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World Journal of Gastroenterology 2009年第4期15卷 473-477页

作者： Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt Daniel Batista Valente Barbosa Adméia Souza santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares Postgraduate Course in Medicine and Health Federal University of BahiaSchool of Medicine Federal university of Bahia School of Medicine NASH Project University Hospital Professor Edgard SantosFederal University of Bahia

AIM： To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease （NAFLD） among asymptomatic Brazilian adolescents. METHODS： Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia, northeastern Brazil. The children answered a questionnaire that in- cluded age, gender, race, and medical history, and were submitted to a complete physical exam and abdominal ultrasound. Biochemical exams included： ALT, AST, GGT, C reactive protein （CRP）, fasting glucose, insulin, cholesterol and triglycerides. Criteria for NAFLD included： the presence of steatosis in ultrasound and/or high level of ALT, negative or occasional historic of intake of alcohol （4 140 g/wk）, negative investigation for hepatitis A, B, C, auto-immune hepatitis, Wilson disease and ***： From October, 2005 to October, 2006, the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7± 2.0 years. One hun- dred ninety-nine had central obesity. The prevalence of NAFLD was 2.3%, most of whom were male and white. Insulin resistance （IR） was observed in 22.9% of them and had positive correlations with ALT and GGT （P 〈 0.05）. Elevated CRP was observed in 6.9% of the cases; however, it was not associated with WC, IR or liver enzymes. CONCLUSION： The prevalence of NAFLD in Brazilian adolescents was low. The ethnicity may have influence this frequency in the population studied, which had a large proportion of African descendents.

关键词： Nonalcoholic fatty liver disease Insulinresistance central obesity Ethnicity Adolescents

Hepatocellular carcinoma in patients without cirrhosis: relevance and clinical characteristics

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Hepatoma Research 2018年第5期4卷 22-27页

作者： Kellyane Santana Dias Carvalho Luciano E.Fonseca Helma P.Cotrim Medicine School Universidade Federal da BahiaSalvador 40110-060Brazil university hospital edgar santos Universidade Federal da BahiaSalvador 40110-060Brazil

Aim: The present study evaluated the frequency of hepatocellular carcinoma (HCC) in patients without cirrhosis. Methods: HCC patients were recruited from two reference centers for liver disease in Northeast Brazil from 2010 to 2016. The diagnosis of HCC and cirrhosis was based on international criteria. Results: A total of 169 patients were included, and 16% (27) of the patients did not have hepatocellular carcinoma in non-cirrhosis (HCC-NC). The mean age of HCC-NC was 64.4 ± 11.3 years, and 74.1% of the patients were male. The main risk factors were hepatitis C virus (HCV) in 29.6% (8), nonalcoholic steatohepatitis (NASH) in 14.8% (4) and hepatitis B virus (HBV) in 11.1% (3). Histological HCC diagnosis was performed in 81.5% (22) of the patients, and in 18.5% (5) of these patients, the diagnosis was performed by ultrasonography, computed tomography or nuclear magnetic resonance imaging methods. Single nodules were found in 56% of HCC-NC (14) when assessed by imaging methods. Conclusion: The frequency of HCC-NC was elevated and more common in males. HCV, NASH and HBV were the most frequent risk factors. These data contribute to discussion on future protocols and criteria for the early diagnosis and treatment of HCC in patients with chronic liver disease without cirrhosis.

关键词： Hepatocellular carcinoma primary liver tumor liver cirrhosis

Factors Associated with Low Intake of Dietary Fiber in Inflammatory Bowel Disease Patients

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Health 2014年第11期6卷 1300-1309页

作者： Vanessa Rosa Brito Oliveira Raquel Rocha Mirella Brasil Lopes Fernanda Gomes Coqueiro Naiade Silveira Almeida Sandra santos Valois Genoile Oliveira Santana Department of Sciences of Nutrition School of Nutrition Federal University of Bahia Salvador Brazil Gastroenterology Unit University Hospital Professor Edgard Santos Federal University of Bahia Salvador Brazil

Inflammatory bowel disease patients reduce their intake of foods rich in dietary fibers in an attempt to prevent recurrence of the disease, predisposing these patients to nutritional losses. The aim of this study was to evaluate the intake of dietary fiber and associated factors in a group of patients with inflammatory bowel disease. This was a cross-sectional study with 61 inflammatory bowel disease patients, and all participants were outpatients in Salvador, Bahia. Patients completed a semi-structured questionnaire that included questions about demographics, socioeconomic status and anthropometric and clinical information and a food frequency questionnaire to assess the intake of dietary fiber. The mean intake of dietary fiber was 28.2 ± 14.8 g/day for inflammatory bowel disease patients, 27.9 ± 10.1 g/day for ulcerative colitis (UC) patients and 28.9 ± 21.1 g/days for those with Crohn’s disease (CD) (p > 0.05). Most inflammatory bowel disease patients (52.5%) had intake below that recommended for dietary fiber. Inadequate consumption was present in 56.3% of CD patients and 43.8% of those with UC (p = 0.28). Men had lower fiber intake than women (p = 0.04). No significant associations between fiber intake and disease activity, location, presence of complications, gastrointestinal complaints, and nutrition counseling were found (p > 0.05). The low intake of dietary fiber was present in most patients, and the greatest inadequacy was found in males. Insufficient intake of dietary fiber appears to be linked to demographic features and not necessarily clinical characteristics relevant to inflammatory bowel disease.

关键词： Inflammatory Bowel Disease Dietary Fiber Eating

The role of exosomal long non-coding RNAs in cancer drug resistance

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Cancer Drug Resistance 2019年第4期2卷 1178-1192页

作者： Mireia Cruz De los santos Mihnea P.Dragomir George A.Calin Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA Research Center for Functional Genomics Biomedicine and Translational MedicineIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 40015Romania Department of Surgery Fundeni Clinical HospitalCarol Davila University of Medicine and PharmacyBucharest 022328Romania Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA

One of the major challenges in oncology is drug resistance,which triggers relapse and shortens patients’*** order to promote drug desensitization,cancer cells require the establishment of an ideal tumor microenvironment that accomplishes specific *** achieve this objective,cellular communication is a key ***,cells were believed to restrictively communicate by ligand-receptor binding,physical cell-to-cell interactions and ***,the crosstalk between tumor cells and stroma cells has also been recently reported to be mediated through exosomes,the smallest extracellular vesicles,which transport a plethora of functionally active molecules,such as:proteins,lipids,messenger RNA,DNA,microRNA or long non-coding RNA(lncRNAs).LncRNAs are RNA molecules greater than 200 base pairs that are deregulated in cancer and other *** lncRNAs are highly stable and can be found in several body fluids,being considered potential biomarkers for tumor liquid *** lncRNAs promote angiogenesis,cell proliferation and drug *** role of exosomal lncRNAs in drug resistance affects the main treatment strategies in oncology:chemotherapy,targeted therapy,hormone therapy and ***,knowing the molecular mechanisms by which exosomal lncRNA induce pharmacologic resistance could improve further drug development and identify drug resistance biomarkers.

关键词： Tumor microenvironment extracellular vesicles exosomes non-coding RNA long non-coding RNA drug resistance

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy