The role of exosomal long non-coding RNAs in cancer drug resistance
作者机构：Department of Experimental TherapeuticsThe University of Texas MD Anderson Cancer CenterHoustonTX 77054USA Research Center for Functional GenomicsBiomedicine and Translational MedicineIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 40015Romania Department of SurgeryFundeni Clinical HospitalCarol Davila University of Medicine and PharmacyBucharest 022328Romania Center for RNA Interference and Non-coding RNAsThe University of Texas MD Anderson Cancer CenterHoustonTX 77054USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第4期
页 面：1178-1192页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Dr.Calin is the Felix L.Endowed Professor in Basic Science.Work in Dr.Calin’s laboratory is supported by National Institutes of Health(NIH/NCATS)grant UH3TR00943-01 through the NIH Common Fund Office of Strategic Coordination(OSC)the NCI grants 1R01 CA182905-01 and 1R01CA222007-01A1 an NIGMS 1R01GM122775-01 grant a U54 grant#CA096297/CA096300-UPR/MDACC Partnership for Excellence in Cancer Research 2016 Pilot Project a Team DOD(CA160445P1)grant a Ladies Leukemia League grant a Chronic Lymphocytic Leukemia Moonshot Flagship project a Sister Institution Network Fund(SINF)2017 grant and the Estate of C.G.Johnson Jr
主 题：Tumor microenvironment extracellular vesicles exosomes non-coding RNA long non-coding RNA drug resistance
摘 要：One of the major challenges in oncology is drug resistance,which triggers relapse and shortens patients’*** order to promote drug desensitization,cancer cells require the establishment of an ideal tumor microenvironment that accomplishes specific *** achieve this objective,cellular communication is a key ***,cells were believed to restrictively communicate by ligand-receptor binding,physical cell-to-cell interactions and ***,the crosstalk between tumor cells and stroma cells has also been recently reported to be mediated through exosomes,the smallest extracellular vesicles,which transport a plethora of functionally active molecules,such as:proteins,lipids,messenger RNA,DNA,microRNA or long non-coding RNA(lncRNAs).LncRNAs are RNA molecules greater than 200 base pairs that are deregulated in cancer and other *** lncRNAs are highly stable and can be found in several body fluids,being considered potential biomarkers for tumor liquid *** lncRNAs promote angiogenesis,cell proliferation and drug *** role of exosomal lncRNAs in drug resistance affects the main treatment strategies in oncology:chemotherapy,targeted therapy,hormone therapy and ***,knowing the molecular mechanisms by which exosomal lncRNA induce pharmacologic resistance could improve further drug development and identify drug resistance biomarkers.
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