Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

作     者：Ana Paula C.Santos Marcos S.Vieira Debora F.Deus Rogerio Jorge Bde Oliveira Aleksandra T.Morikawa Roque Aras Ajax M.Atta Fabio D.Couto Raul C.Maranhao Ricardo D.Couto 

作者机构：Clinical Biochemistry LaboratoryDepartment of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Naval Hospital of SalvadorBrazilian Marine ForcesSalvadorBrazil Lipid Metabolism Laboratory of the Heart Institute(InCor-Clinical Hospital of Medical School)Faculty of PharmacyUniversity of Sao Paulo/USPSao PauloBrazil Ana Neri HospitalSESAB and Federal University of Bahia/UFBA Faculty of MedicineSalvadorBrazil Laboratory of Research in Immunology(LAPIM)Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Laboratory of Molecular Biology and Genetics at Center of AgriculturalEnvironmental and Biological Sciences(CCAAB-UFRB)Cruz das AlmasBrazil Faculty of Pharmaceutical SciencesClinical Chemistry DepartmentUniversity of Sao Paulo/USPSao PauloBrazil Central Clinical Laboratory of Professor Edgar Santos University HospitalFederal University of Bahia/UFBASalvadorBrazil 

出 版 物：《Journal of Biophysical Chemistry》 (生物物理化学（英文）)

年 卷 期：2014年第5卷第2期

页      面：24-32页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Foundation for Research Support of the State of Bahia—FAPESB/SESAB/MS/CNPq Foundation of Research Support and Extension—FAPEX/UFBA 

主　　题：Dyslipidemia Atherogenic Indices Cardiovascular Risk 

摘      要：Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.