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Chinese Journal of Natural Medicines 2023年第12期21卷 884-885页

作者： HOU Xiaoying LIU Yuchen DU Hongzhi Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan 430000China Cancer Institute School of MedicineJianghan UniversityWuhan 430000China School of Pharmacy Hubei University of Chinese MedicineWuhan 430000China center of Traditional Chinese Medicine Modernization for Liver diseases Hubei University of Chinese MedicineWuhan 430000China

Emerging epidemiological findings indicate a rising incidence of primary liver cancer,now a foremost contributor to cancer-related mortalities worldwide[1].Several factors play a pivotal role in liver cancer etiology,including infections from the Hepatitis B/C virus,a spectrum of liver diseases like alcoholic and nonalcoholic fatty liver diseases(NAFLD,ASH,and NASH),metabolic aberrations(e.g.,obesity,diabetes),exposure to hepatocarcinogens(e.g.,aflatoxin,aristolochic acid,and iron overload),and disruptions in gut *** liver diseases,encompassing conditions such as NAFLD and NASH,represent hepatic expressions of metabolic syndrome and bear the potential to culminate in liver cancer.

关键词： cancer diseases liver

The molecular and cellular basis of Apert syndrome

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The molecular and cellular basis of Apert syndrome

Screening and expression analysis of lncRNAs in high-risk MDS

第八届全国医学生物化学与分子生物学第五届全国临床应用生物化学与分子生物学2013华东六省一市生物化学与分子生物学联合学术研讨会

作者： Liu Chao Cui YaZhou Luan Jing Zhou XiaoYan Han JinXiang Shandong Academy of Medical Sciences Shandong Medical Biotechnology CenterKey Laboratory for Biotech-Drugs of the Ministry of Health

Apert syndrome(AS) is an autosomal dominant *** by craniosynostosis,midface hypoplasia,and severe syndactyly of the hands and feet,with a prevalence of 1 in 65,000 *** patients generally require lifelong multidisciplinary *** the last several *** studies have been done to gain a better understanding of molecular basis of the *** balance between the proliferation,differentiation and apoptosis of osteoblasts is essential for the cranial bone and limb *** fgfr2 gain-of-function mutation(S252 W and P253 R) which caused most Apert syndromes alter the *** this ***’ll focus on how the mutated fgfr2 change the balance and their signal *** will provide us a new insight into the pathogenesis of the Apert syndrome.

关键词： Apert syndrome Fgfr2 Osteoblast pathogenesis

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Screening and expression analysis of lncRNAs in high-risk MD...

The influence of agriculture in the process of population integration and cultural interaction during the Eastern Zhou Period in central-south, Inner Mongolia: Carbon and nitrogen stable isotope analysis of human bones from the Dabaoshan cemetery, Helingee

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Wei,Sixi Huang,Yanjie Ma,Yucan Zhao,Juanjuan Ma,Li Kong,Weiying Bi,Ying Huang,Hai Division of Clinical Biochemistry and Molecular Diagnostics in center for Clinical Laboratory Medicine Affiliated Hospital to Guizhou Medical University

Objection:Aimed to screen out the differentially expressed lncRNAs and verify its expression,exploring lncRNAs marker for diagnosis and therapeutics relevant to ***:Three cases bone marrow from patients with high-risk MDS and three healthy donors were collected respectively for lncRNA microarray;bioinformatics analysis was performed to predict the potential interactional targets of lncRNA;Peripheral blood of 20 patients with high-risk MDS and 20 healthy donors were employed for expression verification and co-expression analysis by SYBR-green ***:Microarray profiling indicated 150 differentially expressed lncRNAs in bone marrow of patients with high-risk MDS,of which 119 lncRNAs showed *** CDKN2-AS as a study target,which over-expressed in MDS with 3.27 folds of logFC compared to healthy *** analysis showed that RUNX1 was a potential target of mutual effect to CDKN2-AS;CDKN2-AS was highly expressed in 20 high-risk MDS patients,with a relative expression of 49.74±109.55,while low expressed in healthy donors with a relative expression of 0.56±2.35,significant difference was showed between the two groups,p<0.01;while RUNX1 was low expressed in high-risk MDS patients,the relative expression level indicated significant difference in MDS and healthy donors,p < ***:CDKN2-AS is a potential marker of MDS and its’ expression is associated with the prognosis of MDS.

关键词： Myelodysplastic syndrome long-chain non-coding RNA lncRNA CDKN2-AS RUNX1 bioinformatics analysis

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Science China Earth Sciences 2018年第2期61卷 205-214页

作者： ZHANG XinYu ZHANG Xu SUO MingJie WEI Dong HU YaoWu Department of Archaeology and Anthropology University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Palaeontology and Palaeoanthropology Chinese Academy of Sciences Beijing 100044 China Institute of Archaeology Chinese Academy of Social Sciences Beijing 100710 China College of Culture and History Inner Mongolia Normal University Hohhot 010022 China Research center of Chinese Frontier Archaeology of Jilin University Changchun 130012 China

Central-south Inner Mongolia, China, is highly sensitive to the cultural interactions between sedentary agriculturalists and nomadic pastoralists during the Eastern Zhou Period(770–256 BC). The previous pattern of multiple cultures and diverse ethnic groups has been transformed to the increasingly dominated cultural system of Central Plain since the middle and late Warring States Period, when the states of Zhao and Qin have conquered the most parts of central-south Inner ***, the variation of subsistence strategies during this historical process has never been evaluated. Particularly, as the typical representative of Central Plain cultures, the effect of intensive millet agriculture is still unknown in the process of population integration and culture interaction. Thus, to explore the shift of subsistence pattern, carbon and nitrogen stable isotope analysis of bone collagen from Dabaoshan site(410–180 BC) have been performed. The isotopic result indicates a large amount of C_4-based animal protein consumed by Dabaoshan humans. According to the archaeological backgrounds, we propose the Dabaoshan persons intensively relied on the millet agriculture and developed the agro-pastoral economy, which hinted the comprehensive influences from Central plain civilizations in late Warring States Period. Further compared with other published isotopic data in the same region during different periods, we suggest the millet agriculture has played the positive role in the process of population integration and culture fusion in central-south Inner Mongolia during the Eastern Zhou Period.

关键词： Dabaoshan cemetery Central-south Inner Mongolia Millet agriculture Carbon and nitrogen stable isotope

Mechanisms of Plant Responses and Adaptation to Soil Salinity

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The Innovation 2020年第1期1卷 69-109页

作者： Chunzhao Zhao Heng Zhang Chunpeng Song Jian-Kang Zhu Sergey Shabala Shanghai center for Plant Stress Biology and CAS center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesShanghai 200032China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China State Key Laboratory of Plant Molecular Genetics Shanghai Center for Plant Stress BiologyCenter of Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907USA International Research Centre for Environmental Membrane Biology Foshan UniversityFoshan 528000China Tasmanian Institute of Agriculture University of TasmaniaHobartTAS 7001Australia

Soil salinity is a major environmental stress that restricts the growth and yield of *** the physiological,metabolic,and biochemical responses of plants to salt stress and mining the salt tolerance-associated genetic resource in nature will be extremely important for us to cultivate salt-tolerant *** this review,we provide a comprehensive summary of the mechanisms of salt stress responses in plants,including salt stress-triggered physiological responses,oxidative stress,salt stress sensing and signaling pathways,organellar stress,ion homeostasis,hormonal and gene expression regulation,metabolic changes,as well as salt tolerance mechanisms in *** questions regarding salt tolerance that need to be addressed in the future are discussed.

关键词： stress Plant salinity

Enhancing cell adhesive and antibacterial activities of glass-fibre-reinforced polyetherketoneketone through Mg and Ag PIII

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Regenerative Biomaterials 2023年第1期10卷 1278-1293页

作者： Xin Tan Zhongyi Wang Xin Yang Ping Yu Manlin Sun Yuwei Zhao Haiyang Yu State Key Laboratory of Oral diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduChina Chongqing Key Laboratory of Oral diseases and Biomedical Sciences College of StomatologyChongqing Medical UniversityChongqingChina Jiangsu Key Laboratory of Oral diseases Affiliated Hospital of StomatologyNanjing Medical UniversityNanjingChina Department of Stomatology Chengdu Second People’s HospitalChengduChina

Glass-fibre-reinforced polyetherketoneketone(PEKK-GF)shows great potential for application as a dental implant restoration material;however,its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue,which is critical in the long-term success of implant ***,functional magnesium(Mg)and silver(Ag)ions were introduced into PEKK-GF by plasma immersion ion implantation(PIII).Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII *** tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg^(2+)and Ag^(+)modulated by Giavanni *** vitro experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and *** addition,the treated samples inhibited the metabolic viability and adhesion of Streptococcus mutans and Porphyromonas gingivalis on their surfaces,distorting bacterial ***/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF,which will further support and broaden its adoption in dentistry.

关键词： glass-fibre-reinforced polyetherketoneketone plasma immersion ion implantation human gingival fibroblasts antibacterial activity

Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

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Journal of Molecular Cell Biology 2021年第2期13卷 151-154页

作者： Ying Jin Wei Gu Weichang Chen Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Institute for Cancer Genetics and Department of Pathology and Cell Biologyand Herbert Irving Comprehensive Cancer CenterCollege of Physicians&SurgeonsColumbia UniversityNew YorkNY 10032USA Department of Gastroenterology Suzhou Ninth People’s HospitalSuzhou 215200China

Dear Editor,p53 acts as a transcription factor to modulate various types of cellular processes to suppress tumor development(Tackmann and Zhang,2017).The exquisite regulation of p53 functions is of vital importance for cell fate *** it is well accepted that p53-mediated cell-cycle arrest,senescence,and apoptosis serve as major tumor suppression mechanisms,recent studies suggest that other unconventional activities such as ferroptosis are also critically involved in its tumor suppressor function(Li et al.,2012).We and others found that p53 plays an important role in modulating ferroptotic responses through its metabolic targets(Jiang et al.,2015;Jennis et al.,2016;Wang et al.,2016).Ferroptosis is a regulated form of iron-dependent,non-apoptotic cell death characterized by excessive reactive oxygen species(ROS)generation and accumulation of lipid peroxidates(Stockwell et al.,2020).Lipid peroxides are normally eliminated by glutathione peroxidase 4(GPX4)and its co-factor glutathione(GSH),which convert lipid hydroperoxides to non-toxic lipid ***,ferroptosis can be artificially induced by pharmacological agents that disrupt this lipid repair system,allowing lethal accumulation of lipid *** agents include direct GPX4 enzymatic inhibitors,as well as the small molecule erastin,which suppress glutathione synthesis and indirectly suppress GPX4 activation(Stockwell et al.,2020).Although activation of p53 expression is able to modulate ferroptosis induced by GPX4 inhibition in certain cell types(Jiang et al.,2015),p53-mediated ferroptotic responses are also observed upon ROS-induced stress,apparently through a GPX4-independent manner(Chu et al.,2019).Nevertheless,the molecular factors that modulate p53-dependent ferroptosis upon ROS stress need further ***3 is a NAD-dependent deacetylase predominantly localized in mitochondria,which functions in multiple metabolic pathways,including electron transport chain,fatty acid oxidation,a

关键词： metabolism Lipid stress

Inner ear barriers to nanomedicine-augmented drug delivery and imaging

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Journal of Otology 2016年第4期11卷 -页

作者： Jing Zou Ilmari Pyykk Jari Hyttinen Department of Otolaryngology e Head and Neck Surgery Center for Otolaryngology e Head & Neck Surgery of Chinese PLAChanghai HospitalSecond Military Medical University Hearing and Balance Research Unit Field of OtolaryngologySchool of MedicineUniversity of Tampere Department of Electronics and Communications Engineering Bio Medi TechTampere University of Technology

There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.

关键词： Inner ear Nanotechnology Imaging Gene delivery Contrast agents

Osmol gap method for the detection of diethylene glycol in human serum

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World Journal of Emergency Medicine 2010年第2期1卷 104-107页

作者： Michael G Holland Jamie Nelsen Thomas G Rosano Department of Emergency Medicine SUNY Upstate Medical University/Upstate New York Poison Center Syracuse New York/Department of Occupational Medicine Glens Fal Hospital Glens Fall＇ New York U S. Department of Pathology and Laboratory Medicine Albany Medical Center Hospital and College Albany New York US

BACKGROUND： Measurement of the osmol gap （OG） is a technique that is used frequently in toxic alcohol poisonings （ethylene glycol （EG） and methanol） as a rapid means to estimate exposure, and can be performed in virtually all hospital laboratories. The value of the OG has not been previously evaluated for diethylene glycol （DEG） exposures. The primary objective of this study was to evaluate the utility of the OG in estimating DEG serum concentrations using the most common formula that is currently used for estimating methanol, ethanol, and ethylene glycol ***： This was a controlled laboratory investigation using serum samples individually spiked with a known quantity of toxic alcohol compared to no toxic alcohol. Test samples were spiked with ethanol, DEG, EG, and methanol. Serum chemistries and osmolality and osmolarity were determined, and the OG was determined for each ***： The percent error of estimating DEG concentrations of 26.3% was similar to the mean percent error for estimating other alcohol concentrations, 30.5%±5.6% （P〉0.05, 95% confidence interval 16.7%-44.3%）.CONCLUSION： The severity of metabolic effects associated with DEG and the need to appropriately determine rescue treatments mandate early detection of significant exposures for effective triage and patient management. Our results indicate that the percent error of the osmol gap method for estimating DEG concentration is similar to that of other toxic alcohols; this simple technique could be a valuable clinical tool, since quantitative DEG analysis is rarely available.

关键词： Diethylene glycol Osmol gap metabolic acidosis

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关节镜下骨-髌腱-骨移植重建前十字韧带

中华骨科杂志 2004年第3期24卷 137-140页

作者：冯世庆郭世绂王沛马信龙郑永发孙振辉刘涛 Jeyan Krishnan 天津医科大学总医院骨科 300052 Flinders Medical center Ade-laideAustralia

目的关节镜下以可吸收界面螺钉固定骨-髌腱-骨(bone-patellartendon-bone,BPB)重建膝前十字韧带(ACL),并分析影响疗效的因素。方法1999年12月～2003年6月,采用关节镜下可吸收界面螺钉固定BPB移植修复ACL损伤32例,男22例,女10例;年龄20... 详细信息

目的关节镜下以可吸收界面螺钉固定骨-髌腱-骨(bone-patellartendon-bone,BPB)重建膝前十字韧带(ACL),并分析影响疗效的因素。方法1999年12月～2003年6月,采用关节镜下可吸收界面螺钉固定BPB移植修复ACL损伤32例,男22例,女10例;年龄20～45岁,平均32.5岁;左膝18例,右膝14例。急性损伤8例,陈旧性损伤24例。术前膝关节功能Lysholm评分平均为(52.1±5.6)分。行膝前小切口切取BPB并修整,建立骨隧道,安放胫骨侧骨块时外旋90°以适应ACL前内和后外两束的解剖结构和生理功能,采用可吸收界面螺钉固定BPB两端骨块。同时,在关节镜下处理合并损伤。术后早期行CPM功能锻炼。结果32例患者均获随访,随访6～40个月,平均32个月。采用改良Lysholm评分标准评价疗效:优24例,良7例,可1例;术后膝关节功能Lysholm评分为(98.7±3.6)分,与术前相比差异有显著性(P<0.05)。结论关节镜下可吸收界面螺钉固定BPB移植重建ACL是一种微创手术,操作简单,疗效肯定。

关键词：关节镜骨-髌腱-骨移植重建前十字韧带