Inner ear barriers to nanomedicine-augmented drug delivery and imaging

作     者：Jing Zou Ilmari Pyykk Jari Hyttinen 

作者机构：Department of Otolaryngology e Head and Neck SurgeryCenter for Otolaryngology e Head & Neck Surgery of Chinese PLAChanghai HospitalSecond Military Medical University Hearing and Balance Research UnitField of OtolaryngologySchool of MedicineUniversity of Tampere Department of Electronics and Communications EngineeringBio Medi TechTampere University of Technology 

出 版 物：《Journal of Otology》 (中华耳科学杂志（英文版）)

年 卷 期：2016年第11卷第4期

页      面：-页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(grant number:81170914/H1304) 

主　　题：Inner ear Nanotechnology Imaging Gene delivery Contrast agents 

摘      要：There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.