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Association between Meeting 24-Hour Movement Guidelines and Psychological Features of Chinese Emerging Adults

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International Journal of Mental Health Promotion 2024年第5期26卷 399-406页

作者： Yanjie Zhang Jin Kuang Xun Luo Mengxian Zhao Xiaolei Liu Physical Education Unit School of Humanities and Social ScienceChinese University of Hong Kong–ShenzhenShenzhen518172China Physical Activity and Health Promotion Laboratory Chinese University of Hong Kong–ShenzhenShenzhen518172China Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China School of Physical Education Shenzhen UniversityShenzhen518060China Chinese Traditional Regimen Exercise intervention research center Beijing Sport UniversityBeijing100084China

Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health *** studies have associated these changes with an unhealthy *** 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual ***,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be *** cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging ***:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this *** participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging *** logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four ***:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)***,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.0

关键词： 24-h movement behavior physical activity sedentary behavior sleep psychological health emerging adults

LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

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BIOCELL 2024年第3期48卷 501-511页

作者： YAN LI HUZHI CAI XIAOLING PENG YOUHUI LIU QINGYANG CHEN XIANGDONG LIN XINYU CHEN Department of Vascular and Tumor intervention The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensive Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Nursing research The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensivie Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Endocrinology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Preventive Treatment center The First Hospital of Hunan University of Chinese MedicineChangsha410007China

Background:Renalﬁbrosis is an important process in the development of chronic kidney *** the pathogenesis andﬁnding effective treatments for renalﬁbrosis is *** study aims to investigate whether a newly discovered long non-coding RNA(lncRNA)called LOC103694972 could be a potential target for treatingﬁbrosis of NRK-49F ***:LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal *** dual-luciferase assay conﬁrmed the binding between miR-29c-3p and signal transducer and activator of transcription(STAT3),as well as between miR-29c-3p and lncRNA ***-LOC103694972 and miR-29c-3p mimic were then transfected into TGF-β1-induced NRK-49F ***:The study found that LOC103694972 was highly expressed in TGF-β1-induced NRK-49F *** cells exhibited increased cell length and activity compared to the control *** expression levels of Collagen I,α-Smooth muscle actin(α-SMA),and tissue inhibitor of metalloproteinase(TIMP-1)were increased,while matrix Metalloproteinase 2(MMP2)and matrix Metalloproteinase 9(MMP9)expression was ***,transfection with si-LOC103694972 and miR-29c-3p mimics restored cell morphology and reduced cell *** led to a decrease in the levels of Collagen I,α-SMA,and TIMP-1,as well as an increase in MMP2 and MMP9 ***,TGF-β1-induced NRK-49F cells transfected with miR-29c-3p mimics activated the STAT3-Smad3/CTGF ***:Based on theseﬁndings,lncRNA LOC103694972 shows promise as a target for treating renalﬁ*** negatively regulates miR-29c-3p and activates the STAT3-Smad3/CTGF pathway.

关键词： Renal fibrosis lncRNA LOC103694972 lncRNA Chip miR-29c-3p STAT3-Smad3/CTGF

Advances in the study of gastric organoids as disease models

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1725-1736页

作者： Yi-Yang Liu De-Kun Wu Ji-Bing Chen You-Ming Tang Feng Jiang Graduate School Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Teaching Experiment and Training center Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Central Laboratory Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Digestive Disease Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina aids research center Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina

Gastric organoids are models created in the laboratory using stem cells and sophisticated three-dimensional cell culture *** models have shown great promise in providing valuable insights into gastric physiology and advanced disease *** review comprehensively summarizes and analyzes the research advances in culture methods and techniques for adult stem cells and induced pluripotent stem cell-derived organoids,and patient-derived *** potential value of gastric organoids in studying the pathogenesis of stomach-related diseases and facilitating drug screening is initially *** construction of gastric organoids involves several key steps,including cell extraction and culture,three-dimensional structure formation,and functional *** the structure and function of the human stomach by disease modeling with gastric organoids provides a platform to study the mechanism of gastric cancer induction by Helicobacter *** addition,in drug screening and development,gastric organoids can be used as a key tool to evaluate drug efficacy and toxicity in preclinical *** can also be used for precision medicine according to the specific conditions of patients with gastric cancer,to assess drug resistance,and to predict the possibility of adverse ***,despite the impressive progress in the field of gastric organoids,there are still many unknowns that need to be addressed,especially in the field of regenerative ***,the reproducibility and consistency of organoid cultures are major challenges that must be *** challenges have had a significant impact on the development of gastric ***,as technology continues to advance,we can foresee more comprehensive research in the construction of gastric *** research will provide better solutions for the treatment of stomach-related diseases and personalized medicine.

关键词： Organoids Stomach neoplasms Helicobacter pylori Drug evaluation Preclinical Precision

Development of underwater electric manipulator based on interventional autonomous underwater vehicle (AUV)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 238-250页

作者： Xiaohui HU Jiawang CHEN Hang ZHOU Ziqiang REN Ocean cllege Zhejiang UniversityZhoushan 316021China Hainan Institute Zhejiang UniversitySanya 572025China The Engineering research center of Oceanic Sensing Technology and Equipment Ministry of EducationZhoushan 316021China

In applications such as marine rescue,marine science,archaeology,and offshore industries,autonomous underwater vehicles(AUVs)are frequently used for survey missions and monitoring tasks,with most operations being performed by manned submersibles or remotely operated vehicles(ROVs)equipped with robotic arms,as they can be operated remotely for days without ***,they require expensive marine vessels and specialist pilots to operate *** exploring oceans are no longer satisfied with the use of manned submersibles and *** is a growing desire for seabed exploration to be performed using smarter,more flexible,and automated *** improving the field operation and intervention capability of AUVs,large-scale and long-range seafloor exploration and sampling can be performed without the support of a mother ship,making it a more effective,economical,convenient,and rapid means of seafloor exploration and sampling operations,and playing a critical role in marine resource *** this study,we explored the integration technology of underwater electric robotic arms and AUVs and designed a new set of electric manipulators suitable for water depths greater than 500 *** reliability of the key components was analyzed by finite element analysis and,based on the theory of robot kinematics and dynamics,simulations were performed to verify the reliability of the key *** were conducted on land and underwater,trajectory tracking experiments were completed,and the experimental data in air and water were compared and ***,the objectives for further research on the autonomous control of the manipulator underwater were proposed.

关键词： Underwater electric manipulator Inverse kinematics Trajectory planning Trajectory tracking accuracy

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1690-1705页

作者： Yan Fu Keyu Shen Hao Wang Shun Wang Xufeng Wang Le Zhu Yan Zheng Tiantian Zou Hongfei Ci Qiongzhu Dong Lun-Xiu Qin Hepatobiliary Surgery Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan University200040 ShanghaiChina center of interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast University87 Dingjiaqiao Road210009 NanjingChina institutes of Biomedical Sciences Fudan University200032 ShanghaiChina Key Laboratory of Whole-period Monitoring and Precise intervention of Digestive Cancer Shanghai Municipal Health CommissionMinhang HospitalFudan UniversityShanghaiChina

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor *** cells could exhibit a"neural addiction"property and build up local nerve networks to achieve an enhanced neurotransmitter-initiated signaling through nerve growth factor-mediated *** the dysregulated nervous systems might represent a novel strategy for cancer ***,whether intrahepatic cholangiocarcinoma(ICC)could build its own nerve networks and the role of neurotransmitters in the progression ICC remains largely *** staining and Enzyme-linked immunosorbent assay suggested that IcC cells and the infiltrated nerves could generate a tumor microenvironment rich in acetylcholine that promotes IcC metastasis by inducing epithelial-mesenchymal transition(EMT).Acetylcholine promoted iCC metastasis through interacting with its receptor,alpha 5 nicotine acetylcholine receptor subunits(CHRNA5).Furthermore,acetylcholine/CHRNA5 axis activated GSK3β/β-catenin signaling pathway partially through the influx of Ca^(2+)-mediated activation of Ca/calmodulin-dependent protein kinases(CAMKll).In addition,acetylcholine signaling activation also expanded nerve infiltration through increasing the expression of Brain-Derived Neurotrophic Factor(BDNF),which formed a feedforward acetylcholine-BDNF axis to promote ICC ***93,a small-molecule inhibitor of CAMKIll,significantly inhibited the migration and enhanced the sensitivity to gemcitabine of ICC *** all,Acetylcholine/CHRNA5 axis increased the expression ofβ-catenin to promote the metastasis and resistance to gemcitabine of ICC via CAMKIl/GSK3βsignaling,and the CAMKIl inhibitor KN93 may be an effective therapeutic strategy for combating ICC metastasis.

关键词： GSK3β metastasis Alpha

Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

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Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine research center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global center for Infectious Disease and Policy research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

Aspirin interruption before neurosurgical interventions:A controversial problem

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World Journal of Cardiology 2024年第4期16卷 191-198页

作者： Alexander Kulikov Anton Konovalov Pier Paolo Pugnaloni Federico Bilotta Department of Anesthesiology Burdenko National Medical Research Center of NeurosurgeryMoscow 125047Russia Department of Vascular Neurosurgery Burdenko National Medical Research Center of NeurosurgeryMoscow 125047Russia Department of Anesthesiology Critical Care and Pain MedicineUniversity of Rome“Sapienza”Rome 00161Italy

Aspirin is widely used for primary or secondary prevention of ischemic *** the same time,chronic aspirin consumption can affect blood clot formation during surgical intervention and increase intraoperative blood *** is especially important for high-risk surgery,including *** European Society of Cardiology guidelines recommend aspirin interruption for at least 7 d before neurosurgical intervention,but this suggestion is not supported by clinical *** narrative review presents evidence that challenges the necessity for aspirin interruption in neurosurgical patients,describes options for aspirin effect monitoring and the clinical implication of these methods,and summarizes current clinical data on bleeding risk associated with chronic aspirin therapy in neurosurgical patients,including brain tumor surgery,cerebrovascular procedures,and spinal surgery.

关键词： Aspirin Neurosurgery Postoperative complications Bleeding risk Brain tumor surgery Cerebrovascular surgery Spinal surgery

Effectiveness of onsite and online education in enhancing knowledge and use of human immunodeficiency virus pre-and postexposure prophylaxis

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World Journal of Clinical Cases 2024年第22期12卷 5042-5050页

作者： Ying Shao Mei Zhang Li-Jun Sun Hong-Wei Zhang An Liu Xi Wang Ruo-Lei Xin Jian-Wei Li Jiang-Zhu Ye Yue Gao Zhang-Li Wang Zai-Cun Li Tong Zhang Clinic of center for Infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases and Medical Immunology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and aids Prevention and Control Beijing 100050China Institute of STD/aids Prevention and Control Beijing Center for Disease Prevention and ControlBeijing 100013China

BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)***-risk behaviors prevalent among sexually transmitted infection clinic outpatients underscore the need for increased PrEP/PEP education in this *** To investigate the effects of both onsite and online health education on the knowledge of,and willingness to use,PrEP and PEP among individuals receiving PEP *** Participants were drawn from a cohort study on PEP service intervention at an STD/aids outpatient clinic in designated HIV/aids hospitals in Beijing,conducted from January 1 to June 30,*** education was provided both onsite and online during *** assessing knowledge of,and willingness to use,PrEP/PEP were administered at baseline and again at 24 wk *** A total of 112 participants were enrolled in the study;105 completed the follow-up at week *** percentage of participants with adequate knowledge of,and willingness to use,PrEP significantly increased from 65.2%and 69.6%at baseline to 83.8%and 82.9%at the end of the intervention(both P<0.05).Similarly,those with adequate knowledge of,and willingness to use,PEP increased from 74.1%and 77.7%at baseline to 92.4%and 89.5%at week 24(P<0.05).Being between 31 years and 40 years of age,having a postgraduate degree or higher,and reporting a monthly expenditure of RMB 5000 or more were found to be significantly associated with knowledge of PrEP and PEP(both P<0.05).CONCLUSION The findings show that both onsite and online health education significantly improved the knowledge of,and increased willingness to use,PrEP and PEP in individuals utilizing PEP services.

关键词： Human immunodeficiency virus Pre-exposure prophylaxis Post-exposure prophylaxis Health education intervention

Analyses of fin ray types to detect strontium markers in juvenile blunt-snout bream Megalobrama amblycephala

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Ecological Processes 2024年第1期13卷 206-216页

作者： Yahua Zhu Tao Jiang Xiubao Chen Hongbo Liu Quinton Phelps Jian Yang Wuxi Fisheries College Nanjing Agricultural University (WFCNAU) Laboratory of Fishery Microchemistry Freshwater Fisheries Research Center Chinese Academy of Fishery Sciences (FFRCCAFS) Department of Biology Missouri State University (DBMSU)

Background Restocking by introducing hatchery-reared fish into wild habitats aids in the restoration of fishery aquatic ecosystems and reefs to increase the abundance of fish resources, restore the ecological balance of water bodies, and enhance ecosystem functioning. Accurately, rapidly, and effectively evaluating the success of restocking using chemical markers（e.g., strontium [Sr]） remains challenging for fisheries management. Consequently, for nonlethal fish sampling, hard tissues, such as fin rays, have received increasing attention as a target for marking method. However, data on the differences in marking different types of fin rays remain limited. Therefore, we exposed juvenile blunt snout bream individuals（Megalobrama amblycephala） to 0（control group） or 800 mg/L of SrCl2·6H2O（marked group） for 5 days and transferred them into normal aerated water for post-immersion culture. We sampled their pectoral, dorsal, ventral, anal, and caudal fin rays. The Sr marks among the fin types were sampled at 0 and 20 days post-immersion and evaluated using an electron probe micro-analyzer（EPMA） for the five-day Sr/Ca ratios, along with line transect and Sr mapping *** Sr marking signatures were observed in all fin types in the marked group, with a success rate of up to 100%. Although marking efficiency varied among the different fin ray types, the highest Sr/Ca ratios were most often detected in the dorsal fin. Cross-sectional Sr concentration maps of all fin rays sampled showed high-Sr domains in the marked group; in contrast, the entire cross-sections of the control group displayed low Sr contents, indicating successful marking *** Fin ray Sr marking is a successful method for juvenile M. amblycephala, with the advantages of nonlethality and negligible sampling injuries, facilitating the rapid and effective evaluation of Sr marking in restocking M. amblycephala.

关键词： Megalobrama amblycephala Juvenile Fin ray Strontium marking Electron probe micro-analyzer