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Glial progenitor heterogeneity and plasticity in the adult spinal cord

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Neural Regeneration Research 2024年第12期19卷 2567-2568页

作者： Haichao Wei Jia Qian Wu Department of Neurosurgery McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA center for Stem Cell and Regenerative Medicine UT Brown Foundation Institute of Molecular MedicineHoustonTXUSA MD Anderson Cancer center UTHealth Graduate School of Biomedical Sciences HoustonTXUSA

Glial progenitor cells were reported to have the capacity to generate various types of cells in both the central nervous system(CNS)and peripheral nervous *** progenitor cells can respond to diverse environmental signals and transform into distinct populations,each serving specific ***,the adult spinal cord hosts various populations of glial progenitors,a region integral to the central nervous *** development,glial progenitors express glial fibrillary acidic protein(GFAP;Dimou and Gotz,2014).However,the specific identities of GFAP-expressing progenitors in the adult spinal cord were not thoroughly investigated.

关键词： functions plasticity thoroughly

Alpha7 nicotinic receptors as potential theranostic targets for experimental stroke

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Neural Regeneration Research 2024年第5期19卷 939-940页

作者： Maider Garbizu Laura Aguado Abraham Martín Achucarro Basque center for Neuroscience LeioaSpain CIC biomaGUNE Basque Research and Technology AllianceSan SebastianSpain Ikerbasque Basque foundation for Science BilbaoSpain

Inflammatory reflex and cholinergic anti-inflammatory pathway:Innate immune system triggers a local inflammatory response following an injury or a pathogen ***,this inflammatory response is limited by rapid,localized,and adaptive anti-inflammatory responses which are crucial for maintaining ***,the loss of these responses converts a limited and protective inflammatory response into an excessive and harmful ***-inflammatory responses are integrated into the central nervous system,since the central nervous system accumulates information about harmful events,activates defenses,and builds memory for *** the same time,it has been demonstrated that hypothalamic neuronal signaling can be altered by inflammation in peripheral ***,immune cells release neuropeptides and neurotransmitters such as acetylcholine(ACh),the main neurotransmitter of the parasympathetic autonomic nervous system,evidencing the communication between the immune and nervous systems(Tracey,2002).

关键词： protective invasion Alpha

Applying deep learning technique to chiral magnetic wave search

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Chinese Physics C 2024年第8期48卷 170-176页

作者： Yuan-Sheng Zhao Xu-Guang Huang Physics Department and center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

The chiral magnetic wave(CMW)is a collective mode in quark-gluon plasma originated from the chiral magnetic effect(CME)and chiral separation *** detection in heavy-ion collisions is challenging owing to significant background ***[*** et al.,***.C 106,L051901(2022)],we constructed a neural network that accurately identifies the CME-related signal from the final-state pion *** this study,we have generalized this neural network to the case of CMW *** show that,after an updated training,the neural network effectively recognizes the CMW-related ***,we have assessed the performance of the neural network in comparison with other known methods for CMW search.

关键词： deep learning chiral magnetic wave relativistic heavy-ion collisions

Within-host models unravelling the dynamics of dengue reinfections

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Infectious Disease Modelling 2024年第2期9卷 458-473页

作者： Vizda Anam Bruno V.Guerrero Akhil Kumar Srivastav Nico Stollenwerk Maíra Aguiar Basque center for Applied Mathematics Basque CountrySpain Department of Mathematics and Statistics University of Basque CountryBasque CountrySpain Ikerbasque Basque Foundation for ScienceBasque CountrySpain

Caused by four serotypes,dengue fever is a major public health concern *** modeling efforts have mostly focused on primary and heterologous secondary infections,assuming that lifelong immunity prevents reinfections by the same ***,recent findings challenge this assumption,prompting a reevaluation of dengue immunity *** this study,we develop a within-host modeling framework to explore different scenarios of dengue *** previous studies,we go beyond a deterministic framework,considering individual immunological *** deterministic and stochastic models are calibrated using empirical data on viral load and antibody(IgM and IgG)concentrations for all dengue serotypes,incorporating confidence intervals derived from stochastic *** good agreement between the mean of the stochastic realizations and the mean field solution for each model,our approach not only successfully captures primary and heterologous secondary infection dynamics facilitated by antibody-dependent enhancement(ADE)but also provides,for the first time,insights into homotypic reinfection *** study discusses the relevance of homotypic reinfections in dengue transmission at the population level,highlighting potential implications for disease prevention and control strategies.

关键词： infections immunity prevention

Quantifying the strength of magnetic fields using baryon electric charge correlation

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Nuclear Science and Techniques 2024年第8期35卷 5-8页

作者： Xu‑Guang Huang Physics Department and center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

Although heavy-ion collisions generate strong magnetic fields,their direct measurement is a challenging task.A new observable,the baryon electric charge correlation,was recently found to be sensitive to the magnetic field strength and thus could be used as a magnetometer for heavy-ion ***,this observable may shed light on the equation of state and phase structure of quantum chromodynamics(QCD)under magnetic *** and understanding the phase structure of quantum chromodynamics(QCD)is important in contemporary physics[1].

关键词： charge observable magnetic

Astrocyte syncytium:from neonatal genesis to aging degeneration

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Neural Regeneration Research 2024年第2期19卷 395-396页

作者： Min Zhou Shiying Zhong Alexei Verkhratsky Department of Neuroscience Ohio State University Wexner Medical CenterColumbusOHUSA Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achücarro Basque center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain

Modern neuroscience began from all reaching and fierce conflict between“neuronismo and reticulismo”——between neuronal and reticular theories of the organization of the nervous system;the conflict culminated in December of 1906 in Stockholm where Santiago Ramon y Cajal(the proponent of the neuronal doctrine)and Camillo Golgi(who advocated the syncytial reticular organization of neural networks)delivered their Noble prize lectures(Verkhratsky,2009).

关键词： degeneration neonatal aging

Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： Xiao-Hui Zheng Allan Hildesheim Wei-Hua Jia State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical Investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NPC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages I and II are often ***,NPC patients are usually diagnosed with advanced-stage(stages III and IV)at their first *** of NPC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NPC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NPC early ***,we summarize recent advances in biomarkers for the early detection of NPC.

关键词： patients nasopharyngeal Nasopharyngeal

Distributed Region Tracking and Perimeter Surveillance for Second-Order Multi-Agent Systems in Star-Shaped Sets

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Journal of Systems Science & Complexity 2024年第5期37卷 1995-2020页

作者： SHANG Juan MO Lipo MI Rongxin CAO Xianbing School of Mathematics and Statistics Beijing Technology and Business University The Department of foundation Shijiazhuang Institute of Railway Technology School of Computer and Artificial Intelligence Beijing Technology and Business University Research Centre for Agri-Product Quality Traceability Beijing Technology and Business University Coordination center of China National Computer Network Emergency Response Technical Team

This paper investigates region tracking and perimeter surveillance of second-order multi-agent systems, where all agents move within a star-shaped set. First, by coordination transformations,the region tracking problem is converted from the star-shaped sets to a circular region. The authors employ communication and collaboration to complete region tracking and perimeter surveillance tasks,and then revert back to the star-shaped set by using inverse transformations. Second, the authors propose a distributed control strategy based on attractive and interaction potential functions, under which all agents can quickly track a given circular region and move around the perimeter. Finally,the authors validate the effectiveness and performance advantages of the proposed method through simulation experiments.

关键词： Distributed control multi-agent systems star-shaped sets target tracking

Spin asymmetry and dipole moments inτ-pair production with ultraperipheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 15-21页

作者： Dingyu Shao Bin Yan Shu-Run Yuan Cheng Zhang Department of Physics Center for Field Theory and Particle PhysicsFudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research center for Theoretical Nuclear Physics National Natural Science Foundation of China(NSFC)and Fudan UniversityShanghai 200438China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics Peking UniversityBeijing 100871China

The anomalous magnetic(MDM)and electric(EDM)dipole moments of theτlepton serve as crucial indicators of new physics beyond the standard *** azimuthal angular asymmetry as a novel tool in ultraperipheral collisions(UPCs),we attain unparalleled precision in the study of these key *** by the highly linear polarization of coherent photons,this method uniquely enables both the MDM and EDM to contribute to the cos 2φangular distribution in similar ***,our approach substantially narrows the parameter space,excluding more than half of it compared to expected UPC-based measurements reliant solely on the total *** method not only provides improved constraints but also minimizes the need for additional theoretical assumptions,and offers a novel avenue to probe the EDM effects.

关键词： ultraperipheral collisions magnetic and electric dipole moments spin asymmetry