Within-host models unravelling the dynamics of dengue reinfections

作     者：Vizda Anam Bruno V.Guerrero Akhil Kumar Srivastav Nico Stollenwerk Maíra Aguiar 

作者机构：Basque Center for Applied MathematicsBasque CountrySpain Department of Mathematics and StatisticsUniversity of Basque CountryBasque CountrySpain IkerbasqueBasque Foundation for ScienceBasque CountrySpain 

出 版 物：《Infectious Disease Modelling》 (传染病建模（英文）)

年 卷 期：2024年第9卷第2期

页      面：458-473页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Akhil kumar Srivastav acknowledged the financial support by the ministerio de ciencia e innovación(MICINN)of the Spanish Government through the juan de la cierva grant FJC2021-046826-I M.A.acknowledges the financial support by the Ministerio de Ciencia e Innovación(MICINN)of the Spanish Government through the Ramón y Cajal grant RYC 2021-031380-I This research is supported by the Basque Government through the“Mathematical Modeling Applied to Health”Project,BERC 2022–2025 program and by the Spanish Ministry of Sciences,Innovation and Universities:BCAM Severo Ochoa accreditation CEX 2021-001142-S/MICIN/AEI/10.13039/501100011033 

主　　题：infections immunity prevention 

摘      要：Caused by four serotypes,dengue fever is a major public health concern *** modeling efforts have mostly focused on primary and heterologous secondary infections,assuming that lifelong immunity prevents reinfections by the same ***,recent findings challenge this assumption,prompting a reevaluation of dengue immunity *** this study,we develop a within-host modeling framework to explore different scenarios of dengue *** previous studies,we go beyond a deterministic framework,considering individual immunological *** deterministic and stochastic models are calibrated using empirical data on viral load and antibody(IgM and IgG)concentrations for all dengue serotypes,incorporating confidence intervals derived from stochastic *** good agreement between the mean of the stochastic realizations and the mean field solution for each model,our approach not only successfully captures primary and heterologous secondary infection dynamics facilitated by antibody-dependent enhancement(ADE)but also provides,for the first time,insights into homotypic reinfection *** study discusses the relevance of homotypic reinfections in dengue transmission at the population level,highlighting potential implications for disease prevention and control strategies.