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Human genetic and immunological determinants of critical COVID-19 pneumonia

四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical institute Paris France The Rockefeller University & Howard Hughes Medical institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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Effects of biscuit-type feeding supplementation on the neurocognitive outcomes of HIV-affected school-age children:a randomized,double-blind,controlled intervention trial in Kenya

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Family Medicine and Community Health 2017年第4期5卷 245-258页

作者： Kek Khee Loo Shemra Rizzo Qiaolin Chen Robert E.Weiss Catherine A.Sugar Grace Ettyang Judith Ernst Goleen Samari Charlotte G.Neumann Kaiser Permanente Los Angeles Medical Center Department of Pediatrics1526 Edgemont Street5th FloorLos AngelesCAUSA Department of Statistics University of CaliforniaRiverside1438 Olmsted Hall900 University AvenueRiversideCAUSA Novartis Pharmaceuticals Corporation One Health Plaza337/A03.3CEast HanoverNJUSA Department of Biostatistics UCLA Fielding School of Public Health650 Charles Young Drive SouthLos AngelesCAUSA Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLALos AngelesCAUSA School of Public Health Moi UniversityP.O.Box 4606EldoretKenya Department of Nutrition and Dietetics Indiana University School of Health and RehabilitationColeman HallCF 2241140 W.Michigan StreetIndianapolisINUSA Population Research Center University of Texas at Austin305 E.23rd StreetStop G1800AustinTXUSA Department of Community Health Sciences UCLA Fielding School of Public Health650 Charles Young Drive SouthLos AngelesCAUSA

Objective:To determine if meat or soy protein dietary supplementation will enhance the neuro-cognitive performance of HIV-affected children at-risk of malnutrition and food ***:A randomized,double-blind,controlled intervention trial evaluated the effect of nu-tritional supplementation on the neurocognitive outcomes of 49 HIV-affected school-age children in western *** intervention consisted in providing the mother,target child,and siblings with one of three isocaloric biscuit-type supplements-soy,wheat,or beef-on 5 days per week for 18 *** outcomes of the target children were assessed by a battery of eight measures and followed up longitudinally for up to 24 ***:Mixed effects modeling demonstrated significant differences in the rates of increase over time among all three groups(F test degrees of freedom of 2,P<0.05)for Raven’s progressive matrices performance,but not for verbal meaning,arithmetic,digit span backward,forward,and total,embedded figure test,and Beery visual-motor integration ***:HIV-affected school-age children provided with soy protein supplementation showed greater improvement in nonverbal cognitive(fluid intelligence)performance compared with peers who received isocaloric beef or wheat *** nutrients may have an enhancing effect on neurocognitive skills in HIV-affected school-age children.

关键词： Neurocognition neurodevelopment malnutrition HIV nutrition Africa animal source foods meat soy proteins

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Endoscopic ultrasonography guided drainage:Summary of consortium meeting,May 21,2012,San Diego,california

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World Journal of Gastroenterology 2015年第3期21卷 726-741页

作者： Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Monica Gaidhane Carlos Rondon Takao Itoi Marc Giovannini Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medical CenterNew YorkNY 10021United States Department of Surgery University of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil Endoscopy Unit Hospital Universitario Rio Hortega47012 ValladolidSpain Department of Gastroenterology and Hematology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology PaoliCalmettes Institute13273 MarseilleFrance

Endoscopic retrograde cholangiopancreatography(ERCP) is the preferred procedure for biliary and pancreatic *** ERCP is successful in about 95% of cases,a small subset of cases are unsuccessful due to altered anatomy,peri-ampullary pathology,or malignant *** ultrasound-guided drainage is a promising technique for biliary,pancreatic and recently gallbladder decompression,which provides multiple advantages over percutaneous or surgical biliary *** retrospective and some prospective studies have shown endoscopic ultrasoundguided drainage to be safe and *** on the currently reported literature,regardless of the approach,the cumulative success rate is 84%-93% with an overall complication rate of 16%-35%.endoscopic ultrasoundguided drainage seems a viable therapeutic modality for failed conventional drainage when performed by highly skilled advanced endoscopists at tertiary centers with expertise in both echo-endoscopy and therapeutic

关键词： Endoscopic ultrasound Endoscopic ultrasoundguided

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Red Palm Weevil, Rhynchophorus ferrugineus （Olivier）： Economic Importance, Biology, Biogeography and Integrated Pest Management

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Journal of Agricultural Science and Technology(A) 2011年第1X期1卷 1-23页

作者： R. A. A. M. EI-Mergawy A. M. Al-Ajlan IRD UR 0 72 Laboratory of Evolution Genomes and Spdciation UPR 9034 CNRS 91198 Gif-sur-Yvette France University Paris-Sud 11 Orsay Cedex 91405 France Department of Molecular Biology Genetic Engineering and Biotechnology Research Institute Sadat City Minoufeya UniversityEgypt Department of Arid Land Agriculture College of Agriculture & Food Sciences King Faisal University P.O. Box 55009 Hofuf 31982 Kingdom of Saudi Arabia

The Red Palm Weevil (RPW), Rhynchophorus ferrugineus (Olivier), (Coleoptera, Curculionidae, Rhynchophorinae), is an invasive species that is originated from Southeast Asia. It has invaded Middle East and several countries of the Mediterranean Basin during the last three decades where it attacks palm trees. During the last three decades, multiple introductions of RPW to the Middle East, Europe and Caribbean (Island of Curacao, Netherland Antilles), Lebanon and United States of America (Laguna Beach, Orange County, california) (USA) have occurred and the RPW is now a serious pest of many palm species. Duration of all life parameters varies significantly where the entire life cycle takes about 45 to 298 days. Different artificial diets were developed and were tested for mass rearing of RPW. Control of RPW is difficult due to the concealed nature of the life cycle of the pest. Integrated Pest Management (IPM) strategy has been applied successfully to deal with RPW problem. The IPM strategy consists of various preventive and curative methods; those methods were categorized in nine categories in this review. The main objective of this work was to review the existing knowledge on RPW’s different aspects, with an ultimate aim of revealing the actual situation of the research on RPW.

关键词：锈赤扁谷盗红棕象甲生物地理学管理虫害生物学外来入侵物种工程控制

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Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort

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World Journal of Hepatology 2015年第11期7卷 1586-1594页

作者： Jen-Jung Pan Susan P Fisher-Hoch Chaoru Chen Ariel E Feldstein Joseph B Mc Cormick Mohammad H Rahbar Laura Beretta Michael B Fallon Division of Gastroenterology Hepatology and Nutrition Department of Internal Medicine the University of Texas Health Science Center at Houston School of Public Health Brownsville Campus the University of Texas Health Science Center at Houston Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics University of California at San Diego Division of Clinical and Translational Sciences Department of Internal Medicine the University of Texas Health Science Center at Houston Division of Epidemiology Human Genetics and Environmental Sciences School of Public Health the University of Texas Health Science Center at Houston Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer Center

AIM: To investigate the potential burden of nonalcoholic steatohepatitis(NASH) and advanced fibrosis in a hispanic ***: Four hundred and forty two participants with available ultrasonography data from the Cameron County Hispanic Cohort were included in this study. Each participant completed a comprehensive questionnaire regarding basic demographic information, medical history, medication use, and social and family history including alcohol use. Values of the nonalcoholic fatty liver disease fibrosis score(NFS), FIB4 index, BARD score, and Aspartate aminotransferase to Platelet Ratio Index(APRI) were computed using the blood samples collected within 6 mo of liver ultrasonography from each participant. Hepatic steatosis was determined by ultrasonography. As part of univariable analysis, for continuous variables, comparisons among groups were performed with student-t test, one way analysis of variance, and Mann-Whitney test. Pearson χ2 and the Fisher exact test are used to assess differences in categorical variables. For multivariable analyses, logistic regression analyses were performed to identify characteristics associated with hepatic steatosis. All reported P values are based two-sided tests, and a P value of less than 0.05 was considered to indicate statistical ***: The mean age and body mass index(BMI) of the study participants were 49.1 years and 31.3 kg/m2, respectively. Among them, 65.6% were females, 52% had hepatic steatosis, 49.5% had metabolic syndrome, and 29% had elevated aminotransferases. Based on established cut-offs for diagnostic panels, between 17%-63% of the entire cohort was predicted to have NASH with indeterminate or advanced fibrosis. Participants with hepatic steatosis had significantly higher BMI(32.9 ± 5.6 kg/m2 vs 29.6 ± 6.1 kg/m2, P < 0.001) and higher prevalence rates of elevation of ALT(42.2% vs 14.6%, P < 0.001), elevation of aspartate aminotransferase(38.7% vs 18.9%, P < 0.001), and metabolic syndrome(6

关键词： Noninvasive biomarkers Nonalcoholic fattyliver disease Hispanics Ultrasonography Liver fibrosis

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Theranostic applications:Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy

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World Journal of Radiology 2011年第10期3卷 249-255页

作者： Sergio Casciaro National Council of Research Institute of Clinical PhysiologyBioengineering DivisionCampus Universitario EcotekneVia per Monteroni73100 LecceItaly

Modern medicine is expanding the possibilities of receiving "personalized" diagnosis and therapies,providing minimal invasiveness,technological solutions based on non-ionizing radiation,early detection of pathologies with the main objectives of being operator independent and with low cost to *** research activities aim to strongly contribute to these trends by improving the capabilities of current diagnostic imaging systems,which are of key importance in possibly providing both optimal diagnosis and therapies to *** medical diagnostics,cellular imaging aims to develop new methods and technologies for the detection of specific metabolic processes in living organisms,in order to accurately identify and discriminate normal from pathological *** fact,most diseases have a "molecular basis" that detected through these new diagnostic methodologies can provide enormous benefits to ***,this possibility is mainly related to the use of Positron Emission Tomography,with an exposure to ionizing radiation for patients and operators and with extremely high medical *** future possible development of non-ionizing cellular imaging based on techniques such as Nuclear Magnetic Resonance or Ultrasound,would represent an important step towards modern and personalized *** the last decade,the field of nanotechnology has made important progress and a wide range of organic and inorganic nanomaterials are now available with an incredible number of further combinations with other compounds for cellular *** availability of these new advanced nanosystems allows new scenarios in diagnostic methodologies which are potentially capable of providing morphological and functional information together with metabolic and cellular indications.

关键词： Intelligent nanosystems for cellular targeting Magnetic resonance and ultrasound Molecular imaging Non-ionizing diagnostic techniques Personalized medicine in the oncological and vascular field

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Strong tunability of cooperative energy transfer in Mn2＋-doped （Yb3＋, Er3＋）/NaYF4 nanocrystals by coupling with silver nanorod array

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Nano Research 2015年第9期8卷 2970-2977页

作者： Yalan Wang Fan Nan Ziqiang Cheng Junbo Han Zhonghua Hao Hongxing Xu Ququan Wang Department of Physics Wuhan University Wuhan 430072 China Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Wuhan 430074 China The Center for Nanoscience and Nanotechnology the School of Physics and Technology & the Institute of Advanced Research Wuhan University Wuhan 430072 China

Fluorescent rare-earth ions are useful for efficient energy transfer via multi- channels with different properties. Tuning these transfer processes in functional rare-earth materials has attracted considerable attention to satisfy the various demands of diverse practical applications. In this study, strong tunabilities of cooperative energy transfer and nonlinear upconversion emissions are realized using （Yb3＋, Er3＋）/NaYF4 nanocrystals with and without doped Mn2~ ions by adopting a plasmonic nanocavity composed of a silver nanorod array. The plasmon nanocavity can not only increase the energy transfer between Mn2＋ and （Yb3＋, Er3＋） but also significantly enhance the radiative emission. This reveals a prominent nonlinear gain in the nanocavity nanosystems. These observations suggest the prospective applications in the design and preparation of rare-earth nanocrystals with excellent tunabilities of multiple functionalities.

关键词： surface plasmon resonance,rare-earth nanocrystal,silver nanorod array,upconversionphotoluminescence,cooperative energy transfer

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A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael J.Parsley Edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

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COMMONLY USED RADIOACTIVE SOURCES

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Chinese Physics C 2014年第9期38卷 466-466页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington S.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck-institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

Table 36.1. Revised November 1993 by E. Browne （LBNL）.＂Emission probability＂ is the probability per decay of a given emission; because of cascades these may total more than 100%. Only principal emissions are liste... 详细信息

关键词： In Pb COMMONLY USED RADIOACTIVE SOURCES Cs

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SU(3) ISOSCALAR FACTORS AND REPRESENTATION MATRICES

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Chinese Physics C 2014年第9期38卷 506-506页

Written by R.L. Kelly （LBNL）. The most commonly used SU（3） isoscalar factors, corresponding to the singlet, octet, and deeuplet content of 8 8 and 10 8, are shown at the right. The notation uses particle names to identify the coefficients, so that the pattern of relative couplings may be seen at a glance. We illustrate the use of the coefficients below.

关键词： EK SU ISOSCALAR FACTORS AND REPRESENTATION MATRICES

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