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Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers

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World Journal of Radiology 2015年第11期7卷 382-393页

作者： Musaddiq J Awan Farzan Siddiqui David Schwartz Jiankui Yuan Mitchell Machtay Min Yao Department of Radiation Oncology Case Comprehensive Cancer Center University Hospitals and Case Western Reserve University School of Medicine Department of Radiation Oncology Henry Ford Health System Department of Radiation Oncology University of Texas Southwestern Medical Center

18-fluorodeoxygluocose positron emission tomography/computed tomography(18FDG-PET/CT) provides significant information in multiple settings in the management of head and neck cancers(HNC). This article seeks to define the additional benefit of PET/CT as related to radiation treatment planning for squamous cell carcinomas(SCCs) of the head and neck through a review of relevant literature. By helping further define both primary and nodal volumes, radiation treatment planning can be improved using PET/CT. Special attention is paid to the independent benefit of PET/CT in targeting mucosal primaries as well as in detecting nodal metastases. The utility of PET/CT is also explored for treatment planning in the setting of SCC of unknown primary as PET/CT may help define a mucosal target volume by guiding biopsies for examination under anesthesia thus changing the treatment paradigm and limiting the extent of therapy. Implications of the use of PET/CT for proper target delineation in patients with artifact from dental procedures are discussed and the impact of dental artifact on CT-based PET attenuation correction is assessed. Finally, comment is made upon the role of PET/CT in the high-risk post-operative setting, particularly in the context of radiation dose escalation. Real case examples are used in these settings to elucidate the practical benefits of PET/CT as related to radiation treatment planning in HNCs.

关键词： Head and neck cancer Radiation treatment planning

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Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia school of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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人牙髓干细胞来源的外泌体在体外促进人牙髓干细胞分化及矿化

人牙髓干细胞来源的外泌体在体外促进人牙髓干细胞分化及矿化

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2019年中华口腔医学会老年口腔医学专业委员会第十四次全国老年口腔医学学术年会

作者：龚婷吴红崑楼北雁 Peter X.Ma 口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院老年口腔科 Department of Biologic and Materials Science School of DentistryUniversity of Michigan

目的:外泌体(Exosomes,Exos)是一种包含了复杂RNA和蛋白质的由细胞分泌的直径为50-150nm的盘状囊泡。由于外泌体可调节受体细胞相关生物活动,并且没有天然或组织工程干细胞移植的免疫排异反应,因而在组织再生领域逐渐受到重视。本研究... 详细信息

目的:外泌体(Exosomes,Exos)是一种包含了复杂RNA和蛋白质的由细胞分泌的直径为50-150nm的盘状囊泡。由于外泌体可调节受体细胞相关生物活动,并且没有天然或组织工程干细胞移植的免疫排异反应,因而在组织再生领域逐渐受到重视。本研究旨在探讨人牙髓干细胞(human dental pulp stem cells,hDPSCs)外泌体在体外促进hDSPCs分化及矿化的作用。方法:hDPSCS在促矿化培养基(odontogenic media,OM)中培养14天后,从上清液中分离出外泌体,命名为OM-hDPSCExos。通过直径表征和特异性表面标记物证明提取的为外泌体。利用hDPSCs研究外泌体对其迁移、分化和矿化的影响。结果:茜素红染色显示,OM+OM-hDPSC-Exos处理后14天,基质矿化程度明显高于单纯OM处理。实时聚合酶链反应结果显示,在OM中添加OM-hDPSC-Exos 14天后,牙本质唾液磷蛋白(DSPP)和runt相关转录因子2 (RUNX2)表达上调。Transwell迁移实验表明,OM-hDPSCExos引起细胞迁移的多少与外泌体浓度成正比。结论:OM-hDPSC-Exos与OM协同诱导hDPSCs向成牙细胞分化,并在体外诱导矿化。来自hDPSCs的外泌体可能是一种很有前途的促进牙本质再生的工具。

关键词：外泌体人牙髓干细胞矿化

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50例威廉姆斯综合征希腊患儿的临床表征和分子学研究

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 62-62页

作者： Amenta S. Sofocleous C. Kolialexi A. H. Fryssira 贺文龙 Athens University School of Medicine Aghia Sophia Children's Hospital Goudi P.C. 11527 A thens Greece Dr.

Williams syndrome (WS) is a well- recognized neurodevelopmental disorder man ifested by both connective tissue and CNS abnormalities. The study depicts the 8 - y experience and follow- up of 50 Greek children with the clinical diagnosis of WS. Clinical data on the facial features and cardiovascular, endocrinologic, and neurodevelopmental evaluation are presented. The most consistent findings w ere dysmorphic features (100% ), followed by dental anomalies (90% ) and hyper acousis (90% ). Only eight of 50 children had severe cardiovascular defects tha t required surgical intervention during the first year of life. Supravalvular ao rtic stenosis was less frequent (28% ) than shown in the literature. Severe hyp ertension was noticed in 22% of our patients, and infantile hypercalcemia was noticed in 6% . Twelve percent of our patients showed an elevation of CPK. Most children presented with moderate to severe mental retardation with IQ ranging f rom 20 to 85. Elastin hemizygosity was detected by fluorescence in situ hybridiz ation. Dinucleotide repeat polymorphism analysis was performed in an attempt to correlate phenotype with genotype. The origin of deletions was more frequently m aternal (59% ), and a more severe phenotype seemed to be associated with those deletions. This is the first report on WS patients in the Greek population.

关键词：分子学威廉姆斯神经发育主动脉瓣膜狭窄高钙血症发育性面部畸形听觉过敏中枢神经系统半合子

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不确定事宜感染性心内膜炎发生风险患者在牙科操作前需要应用抗生素吗？

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英国医学杂志中文版 2018年第1期21卷 47-54页

作者： Thomas J Cahill Mark Dayer Martin Thornhill 梁平平仲琳杨军 Oxford Heart Centre Oxford UniversityHospitals NHSFoundation TrustOxford UK Department ofcardiology Tauntonand Somerset NHSFoundation TrustMusgrove ParkTaunton UK Department ofcardiology Guy's andSt Thomas' HospitalsNHS FoundationTrust London UK Department of oraland maxillofacialmedicine surgery &pathology Universityof Sheffield School of Clinical DentistrySheffield. UK 青岛大学附属烟台毓璜顶医院心内科

研究表明感染性心内膜炎的年病死率可达30％，是一种能威胁生命安全的疾病。每10万人群中每年有3～10个人感染该病，也就是说全科医生平均每20年遇到1例该患者。细菌通过口腔、肠道或皮肤进入血液，并在心脏内繁殖形成“植被”，

关键词：不确定事宜感染性心内膜炎患者牙科

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疑似的视网膜激光损伤的诊断

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 32-32页

作者：秦雪娇 Mainster M.A Stuck B.E Brown Jr.J Department of Ophthalmol og y Uni-versity of Kansas Medical SchoolMa il Stop 30093901Rainbow Blvd.Kansas CityKS 66160-7379U-nited States.Dr

Accidental retinal laser injuries a re easily diagnosed when there are known laser sources,typic al macular injuries,and visual deficits consistent with retinal ***-sions are more difficult when retinal findings are subtle or absent,despite reported visual pro blems and somatic *** diagnosis o f an ocular laser injury can precipitate a costly,lengthy se quence of medical and legal *** of laser-tissue interactions and the characteristics of unambiguous retinal laser injuries provide6key questions to facilitate diffic ult *** reports demonstrate the usefulness of answering these questions before making diagnostic *** laser lesions that cause serious visual pr oblems are readily ap-parent ophthalmoscopically and ***-dental,intentional,or clinical re tinal laser lesions do not cause chronic eye,face,or head pain *** of a retinal laser injury should be evidence based,not a matter of conjecture or speculation.

关键词：激光损伤视力损害检眼镜检查眼部症状激光源血管造影协助诊断

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如何设计高质量针刺临床研究:基于证据的专家共识

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英国医学杂志中文版 2022年第6期25卷 325-337页

作者：张誉清焦睿珉 Claudia M Witt 劳力行刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟刘保延刘志顺刘岩郑晖吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 中国中医科学院针灸研究所中国中医科学院广安门医院中加整合医学循证医学研究合作中心 Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonONCanada 宁波诺丁汉大学宁波诺丁汉GRADE中心中国中医药循证医学中心 Institute for Complementary and Integrative Medicine University Hospital Zurich and University of ZurichZurichSwitzerland Virginia University of Integrative Medicine FairfaxVAUSA 北京中医药大学循证医学中心北京中医药大学国际循证中医药研究院 Department of Medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada Kaiser Permanente Washington Health Research Institute Seattle WAUSA Department of Epidemiology University of WashingtonSeattle WAUSA British Medical Acupuncture Society LondonUK Patient and Public Engagement Clinical Trials OntarioTorontoONCanada Department of Western Medicine Virginia University of Integrative MedicineFairfaxVAUSA Korean Medicine Clinical Trial Center SeoulRepublic of Korea Korean Medicine Hospital SeoulRepublic of Korea Kyung Hee University SeoulRepublic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Korean Convergence Medicine University of Science and TechnologyDaejeonRepublic of Korea National Jewish Health DenverCOUSA Institute of Social Medicine Epidemiology and Health EconomicsCharitéUniversit?ts medizin BerlinFreie Universit?t Berlin and Humboldt-Universittzu BerlinBerlinGermany Integrative Medicine Service Memorial Sloan Kettering Cancer CenterBendheim Integrative Medicine CenterNew YorkNY USA Translational Health Research Institute Western Sydney UniversityPenrithNew South WalesAustralia 中国中医科学院中国中医科学院广安门医院北京中医药大学东直门医院中医内科学教育部重点实验室成都中医药大学针灸推拿学院/第三附属医院 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究... 详细信息

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。

关键词：临床流行病学针刺试验临床试验临床医生专家共识随机对照试验资助者期刊编辑

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