Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers
Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers作者机构：Department of Radiation Oncology Case Comprehensive Cancer Center University Hospitals and Case Western Reserve University School of Medicine Department of Radiation Oncology Henry Ford Health System Department of Radiation Oncology University of Texas Southwestern Medical Center
出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第11期
页 面：382-393页
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 100106[医学-放射医学] 10[医学]
主 题：Head and neck cancer Radiation treatment planning
摘 要：18-fluorodeoxygluocose positron emission tomography/computed tomography(18FDG-PET/CT) provides significant information in multiple settings in the management of head and neck cancers(HNC). This article seeks to define the additional benefit of PET/CT as related to radiation treatment planning for squamous cell carcinomas(SCCs) of the head and neck through a review of relevant literature. By helping further define both primary and nodal volumes, radiation treatment planning can be improved using PET/CT. Special attention is paid to the independent benefit of PET/CT in targeting mucosal primaries as well as in detecting nodal metastases. The utility of PET/CT is also explored for treatment planning in the setting of SCC of unknown primary as PET/CT may help define a mucosal target volume by guiding biopsies for examination under anesthesia thus changing the treatment paradigm and limiting the extent of therapy. Implications of the use of PET/CT for proper target delineation in patients with artifact from dental procedures are discussed and the impact of dental artifact on CT-based PET attenuation correction is assessed. Finally, comment is made upon the role of PET/CT in the high-risk post-operative setting, particularly in the context of radiation dose escalation. Real case examples are used in these settings to elucidate the practical benefits of PET/CT as related to radiation treatment planning in HNCs.
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