检索结果-南通市图书馆

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2021年第10期7卷 1413-1423页

作者： Wei Mu Yajie Xu Pengfei Gu Wenbo Wang Jingquan Li Yang Ge Hui Wang center for Single-Cell Omics School of Public Health Shanghai Jiao Tong University School of Medicine CAS Key Laboratory of Nutrition Metabolism and Food Safety Shanghai Institute of Nutrition and Health Chinese Academy of Sciences national research center for Translational Medicine Shanghai Jiao Tong University School of Medicine

Rapid metastasis to vital organs such as the lung,liver,and brain is responsible for the vast majority of pancreatic cancer *** metastasis of pancreatic cancer accounts for the high mortality rate in *** derived from pancreatic cancer cells tend to be enriched in proteins that are anchored to the cell membrane,supporting the reprogramming of the tumor microenvironment and the progression of distant metastatic *** the first time,our study has demonstrated that cluster of differentiation 44(CD44),a transmembrane glycoprotein delivered by exosomes,is involved in the metastatic process of pancreatic ***,CD44 was found to interact with integrin α6β4 to form a complex,thereby remodeling intracellular skeleton proteins,and to promote tumor cell motility through the activation of the Src and Ras signaling ***,we also demonstrated that the CD44-α6β4 complex can be delivered to the target region via the paracrine effects of *** selective uptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways and generated a pre-metastatic niche by stimulating the cytokines,proinflammatory factors,and growth factors that ultimately support tumor *** results suggest the potential application of exosomal CD44 as a biomarker for the clinical diagnosis of and therapy for pancreatic cancer.

关键词： Pancreatic cancer Organotropic metastasis Exosomes Pre-metastatic niche CD44

Molecular mechanisms of exercise contributing to tissue regeneration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第12期7卷 4368-4391页

作者： Jibao Chen Ren Zhou Ye Feng Lin Cheng Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation center) Tongji University School of MedicineShanghaiChina Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Physical activity has been known as an essential element to promote human health for ***,exercise intervention is encouraged to battle against sedentary *** rapid advances in molecular biotechnology have demonstrated that both endurance and resistance exercise training,two traditional types of exercise,trigger a series of physiological responses,unraveling the mechanisms of exercise regulating on the human ***,exercise has been expected as a candidate approach of alleviating a wide range of diseases,such as metabolic diseases,neurodegenerative disorders,tumors,and cardiovascular *** particular,the capacity of exercise to promote tissue regeneration has attracted the attention of many researchers in recent *** most adult human organs have a weak regenerative capacity,it is currently a key challenge in regenerative medicine to improve the efficiency of tissue *** research progresses,exercise-induced tissue regeneration seems to provide a novel approach for fighting against injury or senescence,establishing strong theoretical basis for more and more“exercise mimetics.”These drugs are acting as the pharmaceutical alternatives of those individuals who cannot experience the benefits of ***,we comprehensively provide a description of the benefits of exercise on tissue regeneration in diverse organs,mainly focusing on musculoskeletal system,cardiovascular system,and nervous *** also discuss the underlying molecular mechanisms associated with the regenerative effects of exercise and emerging therapeutic exercise mimetics for regeneration,as well as the associated opportunities and *** aim to describe an integrated perspective on the current advances of distinct physiological mechanisms associated with exercise-induced tissue regeneration on various organs and facilitate the development of drugs that mimics the benefits of exercise.

关键词： organs mechanisms exercise

Biomarker Discovery in Parkinson's disease:Present Challenges and Future Opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第5期33卷 481-482页

作者： Song Li Weidong Le clinical research center on Neurological diseases The First Affiliated Hospital Dalian Medical UniversityDalian 116011 China Liaoning Provincial Key Laboratory for research on the Pathogenic Mechanisms of Neurological diseases The First Affiliated Hospital Dalian Medical UniversityDalian 116011 China Collaborative Innovation center for Brain Science The First Affiliated Hospital Dalian Medical UniversityDalian 116011 China

Parkinson＇s disease （PD） is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the substantia nigra and cytoplasmic inclusions composed of insoluble protein aggregates （Lewy bodies）, which lead to a pro- gressive movement disorder including the classic triad of tremor, bradykinesia, and rigidity.

关键词： PD In Biomarker Discovery in Parkinson’s disease Present Challenges and Future Opportunities

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

在线全文

学校读者我要写书评

暂无评论

Nano research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第11期19卷 1302-1310页

作者： Qiaoli Peng Runhong Zhou Na Liu Hui Wang Haoran Xu Meiqing Zhao Dawei Yang Ka-Kit Au Haode Huang Li Liu Zhiwei Chen AIDS Institute Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China national clinical research center for Infectious diseases HKU AIDS Institute Shenzhen Research LaboratoryThe Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdongPR China Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China Centre for Virology Vaccinology and Therapeutics LimitedThe University of Hong KongHong Kong Special Administrative RegionPR China HKU AIDS Institute Joint Laboratory Department of Clinical Microbiology and Infection ControlThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdongPR China State Key Laboratory of Emerging Infectious disease The University of Hong KongHong Kong Special Administrative RegionPR China

Mutations in SARS-CoV-2 variants of concern(VOCs)have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies(NAbs).How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be *** entry efficiency of individual spike mutations was determined in vitro using pseudotyped ***/c mice were immunized with 2-dose DNA vaccines encoding B.1.1.7,B.1.351,B.1.1.529 and their single *** and humoral immune responses were then compared to determine the impact of individual mutations on *** the B.1.1.7 lineage,Del69–70 and Del 144 in NTD,A570D and P681H in SD1 and S982A and D1118H in S2 significantly increased viral entry,whereas T716I resulted in a *** the B.1.351 lineage,L18F and Del 242–244 in the NTD,K417N in the RBD and A701V in S2 also increased viral entry.S982A weakened the generation of binding *** sera showed reduced cross-neutralization activity against B.1.351,B.1.617.2(Delta)and B.1.1.529(Omicron BA.1).S982A,L18F,and Del 242–244 hindered the induction of cross-NAbs,whereas Del 69–70,Del144,R246I,and K417N showed the opposite effects.B.1.351 elicited adequate broad cross-NAbs against both B.1.351 and *** immunogens tested,however,showed low neutralization against circulating *** addition,T-cell responses were unlikely affected by mutations tested in the *** conclude that individual spike mutations influence viral infectivity and vaccine *** VOC-targeted vaccines is likely necessary to overcome immune evasion from current vaccines and neutralizing antibodies.

关键词： SARS-CoV-2 Variants of Concern Single mutation neutralizing antibody T cell responses vaccine immunogenicity

Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2021年第3期16卷 482-488页

作者： Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand national Eye Centre University of AucklandAucklandNew Zealand Centre for Brain research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain research New Zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

在线全文

学校读者我要写书评

暂无评论

Military Medical research 2022年第5期9卷 543-552页

作者： Kun Xiao Du-Chao Zhang Ye Hu Li-Cheng Song Jian-Qiao Xu Wan-Xue He Pan Pan Yu-Wei Wang Li-Xin Xie center of Pulmonary and Critical Care Medicine Chinese People's Liberation Army(PLA)General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China Department of Pulmonary and Critical Care Medicine Beijing Shijitan HospitalBeijing 100071China Medical School of Chinese People's Liberation Army(PLA) Chinese PLA General HospitalBeijing 100853China Department of Geriatric Comprehensive Surgery the Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China

Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be *** current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy *** patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data *** male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 ***:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients *** healthy control(P<0.001),as well as in the sepsis non-survivor group *** sepsis survivor group(P<0.001,P=0.0338,or P=0.0013,respectively).Lower serum VDBP level was associated with higher Acute Physiology and Chronic Health Evaluation(APACHE)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,P<0.001)and total protein(TP,r=0.263,P=0.02).In CLP mice,there was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day *** was also decreased in LPS-treated THLE2 cells(P<0.001).VDBP overexpression reduced LPS-induced THLE2 *** damage was associated with decreased oxidative stress and inactivation of the c-Jun N-terminal kinase signaling ***:VDBP may be protective against sepsis-induced liver injury.

关键词： Vitamin D binding protein Sepsis Human Mouse Liver Injury c-Jun N-terminal kinase

Twelve weeks of dance exergaming in overweight and obese adolescent girls:Transfer effects on physical activity,screen time,and self-efficacy

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2017年第1期6卷 4-10,127页

作者： Amanda E.Staiano Robbie A.Beyl Daniel S.Hsia Peter T.Katzmarzyk Robert L.Newton Jr Pennington Biomedical research center Baton RougeLA 70808USA

Background: Given the low levels of physical activity(PA) among adolescent girls in the US, there is a need to identify tools to motivate increased PA. Although there is limited evidence that adolescents transfer PA from one context to another, exergames(i.e., video games that require gross motor activity) may act as a gateway to promote overall PA outside game play. The purpose of this study was to examine potential transfer effects(i.e., influences on external behaviors and psychological constructs) of a 12-week exergaming intervention on adolescent girls' PA, screen time,and self-efficacy toward PA, as well as the intrinsic motivation of ***: Participants were 37 girls aged 14–18 years(65% African American, 35% white) who were overweight or obese(body mass index ≥ 85 th percentile) and were recruited from the community via school, physicians, news media, and social media websites. Adolescents were randomly assigned to a 12-week group exergaming intervention(thirty-six 60 min sessions of group-based dance exergaming in a research laboratory using Kinect for Xbox360(Microsoft Corporation, Redmond, WA, USA)) or to a no-treatment control group. Outcome variables included objectively measured PA(total) and self-reported leisure-time PA(discretionary time only) 1 week before vs. 1 week after the intervention; selected type and intensity of PA when placed in a gym setting for 30 min("cardio free choice"); screen time; self-efficacy toward PA; and intrinsic motivation toward ***: Attendance at the exergaming sessions was high(80%). Compared with the control group, the intervention group self-reported an increase in PA(p = 0.035) and fewer hours watching television or videos(p = 0.01) after the intervention, but there were no significant differences in sedentary, light, moderate, or vigorous PA measured by accelerometry. The intervention group significantly improved self-efficacy toward PA(p = 0.028). The intervention group highly rated intri

关键词： Active video games Leisure activity Motivation Screen time Self-efficacy Television