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Paraneoplastic Anti-Tif1-gamma Autoantibody-positive Dermatomyositis as Clinical Presentation of Hepatocellular Carcinoma Recurrence

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 253-259页

作者： Marco Ferronato Claudine Lalanne Chiara Quarneti Michele Cevolani Chiara Ricci Alessandro Granito Luigi Muratori Marco Lenzi Division of Internal Medicine and Immunorheumatology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System University of BolognaBolognaItaly Department of Medical and Surgical Sciences University of BolognaBolognaItaly Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly

Hepatocellular carcinoma(HCC)is rarely associated with autoimmune paraneoplastic *** report a case of anti-transcriptional intermediary factor-1 gamma(TIF1-γ)-positive dermatomyositis(DM)as clinical presentation of HCC recurrence in a 72-year-old male patient admitted to our hospital due to fatigue,myalgia,and typical skin *** medical history was notable for hepatitis C-related cirrhosis,successful treatment with direct-acting antiviral agents,and previously efficacious treatment of *** testing showed significant rhabdomyolysis with antiTIF1-γantibodies at high titer,and DM was *** a careful diagnostic workup,HCC recurrence was *** first-line corticosteroid treatment,azathioprine and intravenous immunoglobulin treatments were administered;unfortunately,he mounted only partial *** to the compromised performance status,no HCC treatment was feasible,and,according to international guidelines,he received only best supportive ***,we discuss the diagnostic,prognostic,and pathogenic roles of anti-TIF1-γantibodies associated with paraneoplastic DM and the scant literature data on its occurrence in HCC *** the TIF1 gene family’s established role in oncogenesis,we also review the role of TIF1-γas a tumor-related neoantigen,leading to the development of clinically overt antiTIF1-γantibodies-positive DM.

关键词： Dermatomyositis Anti-transcriptional intermediary factor-1 gamma(tif1-γ)antibodies Hepatocellular carcinoma Paraneoplastic syndrome

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Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 745-756页

作者： Valeria Tonini Manuel Zanni Department of Medical and Surgical Sciences University of BolognaBologna 40138BolognaItaly

Colorectal cancer(CRC)is one of the most common malignancies in the *** significant improvements in surgical technique,postoperative complications still occur in a fair percentage of patients undergoing colorectal *** most feared complication is anastomotic *** negatively affects shortterm prognosis,with increased post-operative morbidity and mortality,higher hospitalization time and ***,it may require further surgery with the creation of a permanent or temporary *** there is no doubt about the negative impact of anastomotic dehiscence on the short-term prognosis of patients operated on for CRC,still under discussion is its impact on the long-term *** authors have described an association between leakage and reduced overall survival,disease-free survival,and increased recurrence,while other Authors have found no real impact of dehiscence on long term *** purpose of this paper is to review all the literature about the impact of anastomotic dehiscence on long-term prognosis after CRC *** main risk factors of leakage and early detection markers are also summarized.

关键词： Anastomotic leakage Colorectal surgery Colon cancer Rectal cancer Long term prognosis Long term survival

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Early diagnosis of pancreatic cancer:What strategies to avoid a foretold catastrophe

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World Journal of Gastroenterology 2022年第31期28卷 4235-4248页

作者： Valeria Tonini Manuel Zanni Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

While great strides in improving survival rates have been made for most cancers in recent years,pancreatic ductal adenocarcinoma(PDAC)remains one of the solid tumors with the worst *** mortality often overlaps with *** resection is the only potentially curative treatment,but it can be performed in a very limited number of *** order to improve the prognosis of PDAC,there are ideally two possible ways:the discovery of new strategies or drugs that will make it possible to treat the tumor more successfully or an earlier diagnosis that will allow patients to be operated on at a less advanced *** aim of this review was to summarize all the possible strategies available today for the early diagnosis of PDAC and the paths that research needs to take to make this goal ever *** the most recent studies on risk factors and screening modalities,new laboratory tests including liquid biopsy,new imaging methods and possible applications of artificial intelligence and machine learning were reviewed and commented ***,in 2022 the results for this type of cancer still remain discouraging,while a catastrophic increase in cases is expected in the coming *** article was also written with the aim of highlighting the urgency of devoting more attention and resources to this pathology in order to reach a solution that seems more and more unreachable every day.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Early diagnosis Liquid biopsy Pancreatic cancer biomarkers Artificial intelligence Pancreatic cancer screening

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Management of gastro-esophageal reflux disease:Practice-oriented answers to clinical questions

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World Journal of Gastroenterology 2023年第5期29卷 773-779页

作者： Leonardo Frazzoni Lorenzo Fuccio Rocco Maurizio Zagari Department of Digestive Diseases IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S OrsolaBologna 40138Italy Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

Gastro-esophageal reflux disease(GERD)is a condition which is frequently faced by primary care physicians and *** management of GERD is crucial to maximise both patient care and resource *** fact,the management of patients with GERD is complex and poses several questions to the clinician who faces them in clinical *** instance,many aspects should be considered,including the appropriateness of indication to endoscopy,the quality of the endoscopic examination,the use and interpretation of ambulatory reflux testing,and the choice and management of anti-reflux treatments,i.e.,protonpump inhibitors and *** of the present review was to provide a comprehensive update on the clinical management of patients with GERD,through a literature review on the diagnosis and management of patients with GER *** details,we provide practice-oriented concise answers to clinical questions,with the aim of optimising patient management and healthcare resource use.

关键词： Gastro-esophageal reflux disease Diagnosis Management Proton-pump inhibitor

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Virological and histological evaluation of intestinal samples in COVID-19 patients

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World Journal of Gastroenterology 2022年第44期28卷 6282-6293页

作者： Dajana Cuicchi Liliana Gabrielli Maria Lucia Tardio Giada Rossini Antonietta D’Errico Pierluigi Viale Tiziana Lazzarotto Gilberto Poggioli Department of Medical and Surgical Sciences Surgery of the Alimentary TractIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicineMicrobiology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicinePathology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department for Integrated Infectious Risk Management Infectious Diseases UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Infectious Diseases Unit Department for Integrated Infectious Risk ManagementUniversity of BolognaBologna 40138Italy Section of Microbiology Department of ExperimentalDiagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is the pathogen responsible for pandemic coronavirus disease 2019(COVID-19).It is a highly contagious virus which primarily affects the respiratory tract,nevertheless,the lungs are not the only target organs of the *** intestinal tract could represent an additional tropism site for *** observations have collectively suggested that enteric infections can occur in COVID-19 ***,the detection of viral RNA in gastrointestinal(GI)tissue samples has not been adequately investigated and results are *** To detect the presence of SARS-CoV-2 RNA in intestinal mucosa samples and to evaluate histological *** The COVID-19 patients hospitalized at an Italian tertiary hospital from April 2020 to March 2021 were evaluated for enrollment in an observational,monocentric *** study population was composed of two groups of adult *** the first group(biopsy group,30 patients),patients were eligible for inclusion if they had mild to moderate disease and if they agreed to have a rectal biopsy;in the second group(surgical specimen group,6 patients),patients were eligible for inclusion if they underwent intestinal resection during index ***-nine intestinal mucosal samples were *** Viral RNA was not detectable in any of the rectal biopsies performed(0/53).Histological examination showed no enterocyte damage,but slight edema of the lamina propria with mild inflammatory lymphoplasmacytic *** was no difference in inflammatory infiltrates in patients with and without GI ***-CoV-2 RNA was detected in fecal samples in 6 cases out of 14 cases examined(42.9%).In the surgical specimen group,all patients underwent emergency intestinal *** RNA was detected in 2 surgical specimens of the 6 examined,both of which were from patients with active neoplastic *** examination also pointed

关键词： COVID-19 SARS-CoV-2 Intestinal infection Intestinal samples Intestinal tropism Rectal samples

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Empowering digital twins with eXtended reality collaborations

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Virtual Reality & Intelligent Hardware 2022年第6期4卷 487-505页

作者： Lorenzo STACCHIO Alessia ANGELI Gustavo MARFIA Department for Life Quality Studies University of BolognaItaly Department of Computer Science and Engineering University of BolognaItaly Department of the Arts University of BolognaItaly

Background The advancements of Artificial Intelligence,Big Data Analytics,and the Internet of Things paved the path to the emergence and use of Digital Twins(DTs)as technologies to“twin”the life of a physical entity in different fields,ranging from industry to *** the same time,the advent of eXtended Reality(XR)in industrial and consumer electronics has provided novel paradigms that may be put to good use to visualize and interact with *** technologies can support human-to-human interactions for training and remote assistance and could transform DTs into collaborative intelligence *** We here present the Human Collaborative Intelligence empowered Digital Twin framework(HCLINT-DT)integrating human annotations(e.g.,textual and vocal)to allow the creation of an all-in-one-place resource to preserve such *** framework could be adopted in many fields,supporting users to learn how to carry out an unknown process or explore others’past *** The assessment of such a framework has involved implementing a DT supporting human annotations,reflected in both the physical world(Augmented Reality)and the virtual one(Virtual Reality).Con-clusions The outcomes of the interface design assessment confirm the interest in developing HCLINT-DT-based ***,we evaluated how the proposed framework could be translated into a manufacturing context.

关键词： Digital twin eXtended reality Human collaborative intelligence

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3D imaging lipidometry in single cell by in-flow holographic tomography

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Opto-Electronic Advances 2023年第1期6卷 10-25页

作者： Daniele Pirone Daniele Sirico Lisa Miccio Vittorio Bianco Martina Mugnano Danila del Giudice Gianandrea Pasquinelli Sabrina Valente Silvia Lemma Luisa Iommarini Ivana Kurelac Pasquale Memmolo Pietro Ferraro CNR-ISASI Institute of Applied Sciences and Intelligent Systems“E.Caianiello”Via Campi Flegrei 34PozzuoliNapoli 80078Italy Department of Electrical Engineering and Information Technologies University of Naples“FedericoⅡ”via Claudio 21Napoli 80125Italy Department of Chemical Materials and Production Engineering of the University of Naples FedericoⅡPiazzale Tecchio 80Napoli 80125Italy Department of Mathematics and Physics University of Campania“Luigi Vanvitelli”Caserta 81100Italy Biotechnology and Methods in Laboratory Medicine Department of ExperimentalDiagnostic and Specialty Medicine(DIMES)University of BolognaBologna 40126Italy Subcellular Nephro-Vascular Diagnostic Program Pathology Unit S.Orsola IRCCSUniversity of BolognaBologna 40126Italy Unit of Medical Genetics Department of Medical and Surgical Sciences(DIMEC)University of BolognaVia Massarenti 9Bologna 40138Italy Study and Research Center on Gynecological Neoplasias Department of Medical and Surgical Sciences(DIMEC)University of BolognaVia Massarenti 9Bologna 40138Italy Center for Applied Biomedical Research(CRBA) University of BolognaBologna 40138Italy Department of Pharmacy and Biotechnology(FABIT) University of BolognaBologna 40126Italy

The most recent discoveries in the biochemical field are highlighting the increasingly important role of lipid droplets(LDs)in several regulatory mechanisms in living *** are dynamic organelles and therefore their complete characterization in terms of number,size,spatial positioning and relative distribution in the cell volume can shed light on the roles played by *** now,fluorescence microscopy and transmission electron microscopy are assessed as the gold standard methods for identifying LDs due to their high sensitivity and ***,such methods generally only provide 2D assays and partial ***,both can be destructive and with low productivity,thus limiting analysis of large cell numbers in a *** we demonstrate for the first time the capability of 3D visualization and the full LD characterization in high-throughput with a tomographic phase-contrast flow-cytometer,by using ovarian cancer cells and monocyte cell lines as models.A strategy for retrieving significant parameters on spatial correlations and LD 3D positioning inside each cell volume is *** information gathered by this new method could allow more in depth understanding and lead to new discoveries on how LDs are correlated to cellular functions.

关键词： lipid droplets label-free phase-contrast imaging in-flow tomography 3D imaging

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Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli Aude Simongiovanni Tristan Chalvon-Demersay Maddalena Zini Luciano Fusco Paolo Bosi Paolo Trevisi Department of Agricultural and Food Sciences University of Bologna40127 BolognaItaly Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(P<0.05)in the sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(P<0.10)in the sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,Erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(P<0.05).Furthermore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(P<0.05)in the sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,P<0.10)at d 20 in the milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

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Multiple influences of the COVID-19 pandemic on children with diabetes:Changes in epidemiology,metabolic control and medical care

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World Journal of Diabetes 2023年第3期14卷 198-208页

作者： Stefano Zucchini Andrea Scozzarella Giulio Maltoni Department of Pediatric IRCCS AOU di BolognaBologna 40138Italy

The coronavirus disease 2019(COVID-19)pandemic has heavily affected health worldwide,with the various forms of diabetes in children experiencing changes at various levels,including epidemiology,diabetic ketoacidosis rates and medical *** 1 diabetes showed an apparent increase in incidence,possibly owing to a direct damage of the virus to theβ-*** ketoacidosis also increased in association with the general fear of referring patients to the *** children with diabetes(both type 1 and type 2)did not show a worsening in metabolic control during the first lockdown,possibly owing to a more controlled diet by their *** sensor and hybrid closed loop pump technology proved to be effective in all patients with type 1 diabetes during the pandemic,especially because the downloading of data allowed for the practice of *** has in fact grown around the world and National Health Systems have started to consider it as a routine activity in clinical *** present review encompasses all the aspects related to the effects of the pandemic on the different forms of diabetes in children.

关键词： Diabetes COVID-19 Children Diabetic ketoacidosis Telemedicine

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Geophysical evidence of large-scale silica-rich fluid flow above the continental subduction interface

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Science China Earth Sciences 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSà Stefano SOLARINO Silvia PONDRELLI Baolu SUN Coralie AUBERT Simone SALIMBENI Elena EVA Stéphane GUILLOT State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences Department of Earth and Environmental Sciences University of Milano-Bicocca Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale Terremoti Istituto Nazionale di Geofisica e Vulcanologia Sezione di Bologna univ.rsité Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerre

Fluids in subduction zones can have major effects on subduction dynamics. However, geophysical constraints on the scale and impact of fluid flow during continental subduction are still limited. Here we analyze the VP/VSratios in the Western Alpine region, hosting one of the best-preserved fossil continental subduction zones worldwide, to investigate the impact of fluid flow during continental subduction. We found a belt of high VP/VSratios >1.9 on the upper-plate side of the subduction zone,consistent with a partially serpentinized upper-plate mantle, and a belt of unusually low VP/VSratios <1.7 on the lower-plate side,at depths shallower than 30 km. We propose that these low VP/VSratios result from a widespread network of silica-rich veins,indicating past fluid flow along the continental subduction interface. Our results suggest that past fluid flow may have reduced the effective stress along the subduction interface thus favoring continental subduction.

关键词： Western Alps Crustal structure Receiver function VP/VS ratio Silica enrichment

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