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Chinese Journal of Chemical engineering 2020年第2期28卷 340-347页

作者： M.Lavanya V.Ramachandra Murthy Padmalatha Rao Department of biotechnology Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnatakaIndia Department of Chemistry Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnatakaIndia

Erosion corrosion performance of 6061 aluminum alloy in simulated sea water slurry was investigated under multi-phase jet impingement conditions. The main objective of the work is to study erosion–corrosion of a material with engineering application and mitigate it using eco-friendly green inhibitor. Experiments were performed with the sand concentration of 0.3% and 0.3 μm size. The effect of temperature and flow rate on the performance of inhibitor was explored. Electrochemical methods were adopted for erosion-corrosion measurements. Experiments revealed that starch could mitigate erosion-corrosion with a maximum reduction efficiency of 58% at temperature of 303 K and flow rate of 4 L·min–1. Inhibition efficiency decreased with increase in flowrate and temperature. EIS spectrum demonstrated that the corrosion process in the presence on inhibitor was both charge transfer and mass transfer controlled. A key role of hydrodynamics in the performance of corrosion inhibitor was confirmed by the present study.

关键词： Erosion-corrosion Green-inhibitor Electrochemical studies Aluminum alloy Simulated sea water

Tumor-targeting Salmonella typhimurium,a natural tool for activation of prodrug 6MePdR and their combination therapy in murine melanoma model

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Tumor-targeting Salmonella typhimurium,a natural tool for ac...

Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response

2015中国酶工程与糖生物工程学术研讨会

作者： Guo Chen Bo Tang Bing-Ya Yang Jian-Xiang Chen Jia-Hua Zhou Jia-Huang Li Zi-Chun Hua The State Key Laboratory of pharmaceutical biotechnology Nanjing University Department of Biliary-Pancreatic Surgery Zhongda Hospital of Southeast University Shenzhen Research Institute of Nanjing University

＜正＞The PNP/6-methylpurine 2’-deoxyriboside（6MePdR）system is an efficient gene-directed enzyme prodrug therapy system with significant antitumor *** this system,Escherichia coli purine nucleoside phosphorylase（e...

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Animal Nutrition 2022年第4期11卷 402-412页

作者： Shao-Shuai Bi Milton Talukder Hai-Tao Jin Mei-Wei Lv Jing Ge Cong Zhang Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China College of biotechnology and pharmaceutical engineering of West Anhui University Lu’an 237012China Department of Physiology and Pharmacology Faculty of Animal Science and Veterinary MedicinePatuakhali Science and Technology UniversityBarishal8210Bangladesh Quality and Safety Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin 150010China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin 150030China

This study aims to investigate the role of metal regulatory transcription factor 1(MTF1)-mediated metal response in cadmium(Cd)-induced cerebellar injury,and to evaluate the antagonistic effects of nanoselenium(Nano-Se)against Cd toxicity.A total of 80 chicks(1 d old,male,Hy-Line Variety White)were randomly allocated to 4 treatment groups for 3 months:the control group(fed with a basic diet,n=20),the Nano-Se group(basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet,n=20),the NanoSe+Cd group(basic diet with 1 mg/kg Nano-Se and 140 mg/kg Cd Cl_(2),n=20)and the Cd group(basic diet with 140 mg/kg Cd Cl_(2),n=20).The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd ***,exposure to Cd caused a significant accumulation of Cd and ***,the contents of Se,iron,and zinc were decreased,thereby disturbing the metal homeostasis in the *** Cd exposure also resulted in high levels of malondialdehyde(MDA)and down regulation of selenoprotein ***,the expressions of MTF1,metallothionein 1(MT1),MT2,zinc transporter 3(ZNT3),ZNT5,ZNT10,zrt,irt-like protein 8(ZIP8),ZIP10,transferrin(TF),ferroportin 1(FPN1),ATPase copper transporting beta(ATP7B),and copper uptake protein 1(CTR1)were inhibited by Cd ***,all these changes were significantly alleviated by the supplementation of *** study proved that Cd could disorder metal homeostasis and induce oxidative stress,whereas Nano-Se could relieve all these negative effects caused by Cd via activating the MTF1-mediated metal response in the cerebellum of chicken.

关键词： Nano-selenium Cadmium Selenoprotein transcriptome MTF1-mediated metal response Cerebellar injury

Evaluation of safety profile of black shilajit after 91 days repeated administration in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 210-214页

作者： Velmurugan C Vivek B Wilson E Bharathi T Sundaram T Department of Pharmacology Sri Krishna Chaithanya College of Pharmacy Department of Pharmacology Sri K.V College of PharmacyM.G RoadChickballapurKarnataka SRF National Institute of Indian Medical HeritageHyderabad Department of pharmaceutical biotechnology Sri Krishna Chaithanya College of Pharmacy Department of Pharmaceutics Sri Krishna Chaithanya College of pharmacy

Objective:To evaluate the safety of shilajit by 91 days repeated administration in different dose levels in ***:In this study the albino rats were divided into four groups. Group Ⅰ received vehicle and group Ⅱ,Ⅲ and Ⅳ received 500,2500 and 5000 mg/kg of shilajit, *** animals were sacrificed and subjected to histopathology and iron was estimated by flame atomic absorption spectroscopy and graphite ***:The result showed that there were no significant changes in iron level of treated groups when compared with control except liver(5000 mg/kg) and histological slides of all organs revealed normal except negligible changes in liver and intestine with the highest dose of *** weight of all organs was normal when compared with ***:The result suggests that black shilajit,an Ayurvedic formulation,is safe for long term use as a dietary supplement for a number of disoniers like iron deficiency anaemia.

关键词： Shilajit Graphite furnace Histopathology Flame atomic absorption spectroscopy

Diversity and bioactivity of cultured aquatic fungi from the High Arctic region

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Advances in Polar Science 2017年第1期28卷 29-42页

作者： ZHANG Tao ZHAO Lili YU Caiyun WEI Tao YU Liyan China pharmaceutical Culture Collection Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences& Peking Union Medical College Beijing Key Laboratory of Bioactive Substances and Function Food Beijing Union University

This study assessed the diversity and α-glycosidase inhibitory activity of cultured fungi isolated from four aquatic environments （stream, pond, glacial ice, and estuary） in the *** region （Svalbard, Norway, High Arctic）. A total of 134 fungal isolates were obtained from 13 water samples. Based on morphological characteristics and sequence analyses of the nuclear ribosomal DNA internal transcribed spacer region, these fungal isolates were identified as belonging to 47 species, with 26 belonging to the Ascomycota, 20 to the Basidiomycota, and one to the Zygomycota. The most frequently detected fungal species were Vishniacozyma sp. 2, Cadophora sp. 2, Phenoliferia sp. 1, Dioszegia sp. 2, and Mortierella sp.; these species occurred in 10, eight, seven, six, and five of the samples, respectively. Among the 134 fungal isolates, 17 isolates of 15 species displayed high α-glycosidase inhibitory activity in culture. The results suggest that diverse and distinct populations of cultured fungi are present in Arctic aquatic environments, and they include taxa that are potential sources of bioactive molecules that may be used as prototype drugs for medicinal proposals.

关键词： aquatic habitats bioactivity diversity environmental mycology High Arctic

Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy

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Science China Materials 2018年第11期61卷 1404-1419页

作者： Lei Jiang Sensen Zhou Xiaoke Zhang Wei Wu Xiqun Jiang MOE Key Laboratory of High Performance Polymer Materials and Technology and Department of Polymer Science ＆ EngineeringCollege of Chemistry ＆ Chemical EngineeringNanjing UniversityNanjing 210093China State Key Laboratory of Natural Medicines Department of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

This review discusses recent studies on dendrimer-based nanoparticles in cancer chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of chemotherapy and gene therapy, it is essential to combine the unique features of dendrimers and the specific tumor microenvironment to target delivery and control release of therapeutic agents to tumor tissues and cells. Strategies to design the dendrimer-based delivery system in this review include non-modified dendrimers, dendrimer conjugates, assembled amphiphilic dendrimers, nanohybrid dendrimer carriers and dendrimers with inherent activity. In addition, specific functional groups on these dendrimers as stimuli-responsive system for targeting delivery and controlled release of therapeutic agents are discussed.

关键词： dendrimer-based nanoparticles cancer chemotherapy gene therapy

Ipomoea batatas HKT1 transporter homolog mediates K^+ and Na^+ uptake in Saccharomyces cerevisiae

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Journal of Integrative Agriculture 2017年第10期16卷 2168-2176页

作者： PARK Sung-chul YU Yi-cheng KOU Meng YAN Hui TANG Wei WANG Xin LIU Ya-ju ZHANG Yun-gang KWAK Sang-soo MA Dai-fu SUN Jian LI Qiang Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District/Key Laboratory for Biology and Genetic Breeding of Sweet Potato Ministry of Agriculture/Sweet Potato Research InstituteChinese Academy of Agricultural Science Institute of Integrative Plant Biology School of Life ScienceJiangsu Normal University Plant Systems engineering Research Center Korea Research Institute of Bioscience and Biotechnology

Soil salinity causes the negative effects on the growth and yield of crops. In this study, two sweet potato （Ipomoea batatas L.） cultivars, Xushu 28 （X-28） and Okinawa 100 （O-100）, were examined under 50 and 100 mmol L-1 NaCI stress. X-28 cultivar is relatively high salt tolerant than O-100 cultivar. Interestingly, real-time quantitative polymerase chain reaction （RT-qPCR） results indicated that sweet potato high-affinity K^＋ transporter 1 （IbHKT1） gene expression was highly induced by 50 and 100 mmol L-1 NaCI stress in the stems of X-28 cultivar than in those of O-100 cultivar, but only slightly induced by these stresses in the leaves and fibrous roots in both cultivars. To characterize the function of IbHKT1 transporter, we performed ion-flux analysis in tobacco transient system and yeast complementation. Tobacco transient assay showed that IbHKT1 could uptake sodium （Na^＋）. Yeast complementation assay showed that IbHKT1 could take up K^＋ in 50 mmol L^-1 K^＋ medium without the presence of NaCI. Moreover, Na^＋ uptake significantly increased in yeast overexpressing IbHKTI. These results showed that IbHKT1 transporter could have K^＋-Na^＋ symport function in yeast. Therefore, the modes of action of IbHKT1 in transgenic yeast could differ from the mode of action of the other HKT1 transporters in class I. Potentially, IbHKT1 could be used to improve the salt tolerance nature in sweet potato.

关键词： IbHKT1 Na^+/K^+transporter salt stress sweet potato

Plant G proteins interact with endoplasmic reticulum luminal protein receptors to regulate endoplasmic reticulum retrieval

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Journal of Integrative Plant Biology 2018年第7期60卷 541-561页

作者： Shanshan Wang Ke Xie Guoyong Xu Huarui Zhou Qiang Guo Jingyi Wu Zengwei Liao Na Liu Yan Wang Yule Liu MOE Key Laboratory of Bioinformatics Center for Plant Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Advanced biotechnology and Application Research Center School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China The Institute for Advanced Studies (IAS) Wuhan University Wuhan 430072 China

Maintaining endoplasmic reticulum （ER） homeostasis is essential for the production of biomolecules. ER retrieval, i.e., the retrograde transport of compounds from the Golgi to the ER, is one of the pathways that ensures ER homeostasis. However, the mechanisms underlying the regulation of ER retrieval in plants remain largely unknown. Plant ERD2-1ike proteins （ERD2s） were recently suggested to function as ER luminal protein receptors that mediate ER retrieval. Here, we demon- strate that heterotrimeric G protein signaling is involved in ERD2-mediated ER retrieval. We show that ERD2s interact with the heterotrimeric G protein Gα and Gγsubunits at the Golgi. Silencing of Gα, Gβ, or Gγ increased the retention of ER luminal proteins. Furthermore, overexpression of Gα, Gβ, or Gγ caused ER luminal proteins to escape from the ER, as did the co-silencing of ERD2a and ERD2b. These results suggest that G proteins interact with ER luminal protein receptors to regulate ER retrieval.

关键词： Chun-Ming Liu Institute of Crop Science CAAS Institute of Botany CAS China

Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

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Journal of pharmaceutical Analysis 2024年第6期14卷 823-839页

作者： Guiya Yang Yue Liu Yuying Hu Yue Yuan Yunan Qin Quan Li Shuangcheng Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Institute for Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing100050China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine School of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin301617China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of *** discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and *** the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological *** this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is *** pros and cons of each technique are also *** future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

关键词： Electron microscopy Spectroscopy Traditional Chinese medicine Bio-soft matter Structural characterization

Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling:a review

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2024年第4期25卷 280-292页

作者： Siyi LIN Xinyu HE Ying WANG Yu CHEN Aifu LIN College of Medicine Zhejiang UniversityHangzhou 310058China College of Life Sciences Zhejiang UniversityHangzhou 310058China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene engineering of Zhejiang Province Hangzhou 310058China International School of Medicine International Institutes of Medicinethe Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310058China Future Health Laboratory Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Cells within tissues are subject to various mechanical forces,including hydrostatic pressure,shear stress,compression,and *** mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes,shaping the microenvironment and maintaining cellular physiological *** studies have demonstrated the roles of Yes-associated protein(YAP)and its homolog transcriptional coactivator with PDZ-binding motif(TAZ)as mechanotransducers,exerting dynamic influence on cellular phenotypes including differentiation and disease *** regulatory function entails the involvement of the cytoskeleton,nucleoskeleton,integrin,focal adhesions(FAs),and the integration of multiple signaling pathways,including extracellular signal-regulated kinase(ERK),wingless/integrated(WNT),and Hippo ***,emerging evidence substantiates the implication of long non-coding RNAs(lncRNAs)as mechanosensitive molecules in cellular *** this review,we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical ***,we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.

关键词： YAP/TAZ Long non-coding RNA(lncRNA) Mechanotransduction F-actin