Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling:a review

作     者：Siyi LIN Xinyu HE Ying WANG Yu CHEN Aifu LIN Siyi LIN;Xinyu HE;Ying WANG;Yu CHEN;Aifu LIN

作者机构：College of MedicineZhejiang UniversityHangzhou 310058China College of Life SciencesZhejiang UniversityHangzhou 310058China Cancer CenterZhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang ProvinceHangzhou 310058China International School of MedicineInternational Institutes of Medicinethe Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationHangzhou 310058China Future Health LaboratoryInnovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2024年第25卷第4期

页      面：280-292页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation for Distinguished Young Scholars of China(No.32225014) the“Lingyan”R&D Research and Development Project(No.2023C03023) the National Key R&D Program of China(No.2021YFC2700903) the National Natural Science Foundation of China(Nos.81672791 and 81872300) the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(No.LR18C060002) 

主　　题：YAP/TAZ Long non-coding RNA(lncRNA) Mechanotransduction F-actin 

摘      要：Cells within tissues are subject to various mechanical forces,including hydrostatic pressure,shear stress,compression,and *** mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes,shaping the microenvironment and maintaining cellular physiological *** studies have demonstrated the roles of Yes-associated protein(YAP)and its homolog transcriptional coactivator with PDZ-binding motif(TAZ)as mechanotransducers,exerting dynamic influence on cellular phenotypes including differentiation and disease *** regulatory function entails the involvement of the cytoskeleton,nucleoskeleton,integrin,focal adhesions(FAs),and the integration of multiple signaling pathways,including extracellular signal-regulated kinase(ERK),wingless/integrated(WNT),and Hippo ***,emerging evidence substantiates the implication of long non-coding RNAs(lncRNAs)as mechanosensitive molecules in cellular *** this review,we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical ***,we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.