Diversity and bioactivity of cultured aquatic fungi from the High Arctic region

作     者：ZHANG Tao ZHAO Lili YU Caiyun WEI Tao YU Liyan 

作者机构：China Pharmaceutical Culture CollectionInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences& Peking Union Medical College Beijing Key Laboratory of Bioactive Substances and Function FoodBeijing Union University 

出 版 物：《Advances in Polar Science》 (极地科学进展（英文版）)

年 卷 期：2017年第28卷第1期

页      面：29-42页

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (NSFC) (Grant nos.31670025 and 31300115) Projects of the Chinese Arctic and Antarctic Administration,State Oceanic Administration (Grant no.2013YR06006) the National Infrastructure of Microbial Resources (Grant no.NIMR-2017-3) the CAMS Innovation Fund for Medical Sciences (Grant no.2016-I2M-2-002) 

主　　题：aquatic habitats bioactivity diversity environmental mycology High Arctic 

摘      要：This study assessed the diversity and α-glycosidase inhibitory activity of cultured fungi isolated from four aquatic environments （stream, pond, glacial ice, and estuary） in the *** region （Svalbard, Norway, High Arctic）. A total of 134 fungal isolates were obtained from 13 water samples. Based on morphological characteristics and sequence analyses of the nuclear ribosomal DNA internal transcribed spacer region, these fungal isolates were identified as belonging to 47 species, with 26 belonging to the Ascomycota, 20 to the Basidiomycota, and one to the Zygomycota. The most frequently detected fungal species were Vishniacozyma sp. 2, Cadophora sp. 2, Phenoliferia sp. 1, Dioszegia sp. 2, and Mortierella sp.; these species occurred in 10, eight, seven, six, and five of the samples, respectively. Among the 134 fungal isolates, 17 isolates of 15 species displayed high α-glycosidase inhibitory activity in culture. The results suggest that diverse and distinct populations of cultured fungi are present in Arctic aquatic environments, and they include taxa that are potential sources of bioactive molecules that may be used as prototype drugs for medicinal proposals.