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bioactivity of mackerel peptides on obesity and insulin resistance,an in-vivo study

Food Bioscience 2022年第3期47卷 394-402页

作者： Soheila Abachi Hokmabadinazhad Jean-Philippe Songpadith Vanessa P.Houde Geneviève Pilon Ismail Fliss André Marette Laurent Bazinet Lucie Beaulieu Institute of Nutrition and Functional Foods (INAF) Université LavalQuebecQuebecCanada Department of Food Science Faculty of Agricultural and Food SciencesUniversité LavalQuebecQuebecCanada Department of Medicine Faculty of MedicineCardiology Axis of the Quebec Heart and Lung InstituteQuebecQuebecCanada

Of many metabolic irregularity risk factors,glucose intolerance,insulin resistance,and abdominal obesity are the main ones.The risk of vascular diseases and cancers is rather high in such individuals therefore its treatment and prevention are equally important for the health of population.Marine including fish biopeptides have frequently shown to prevent and or ameliorate these risk factors.In our earlier studies,Atlantic mackerel hydrolysate and its fractions showed promising effects on immunity and hypertension.We,therefore,in the current study,aimed to examine the effects of mackerel hydrolysate along its cationic peptides,isolated at pH3 using electrodialysis with ultrafiltration membrane,on metabolic disorder factors in diet-induced insulin resistant obese mice.Mice were fed the chow and or the hypercaloric diet (high fat high sucrose) for the duration of 8-weeks.Subsequently the hypercaloric fed insulin resistant obese mice were gavaged daily either the vehicle and or the test material at the dosage of 208 mg of sample protein per kg mice body weight.According to our observations,mackerel peptides could not effectively modulate food intake,weight gain,adiposity,plasma glucose and insulin concentrations,hepatic cholesterol,and triglyceride levels.Thus,obesity and metabolic impairments could not be averted by the treatments in insulin resistant obese mice.In conclusion,anti-hypertensive,and immunomodulatory attributes of mackerel peptides at the tested concentrations do not seem to be correlated with its metabolic syndrome benefiting effects.To presume a general statement about the metabolic syndrome benefiting potency of Atlantic mackerel's biopeptides further research is warranted.

关键词： Atlantic mackerel bioactivity Cationic peptides Diabetes Obesity

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Using immune cell-based bioactivity assays to compare the inflammatory activities of oil sands process-affected waters from a pilot scale demonstration pit lake

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Journal of Environmental Sciences 2023年第6期128卷 55-70页

作者： Dustin M.E.Lillico Nora A.S.Hussain Yemaya Y.Choo-Yin Rui Qin Zuo Tong How Mohamed Gamal El-Din James L.Stafford Department of Biological Sciences University of AlbertaAlberta T6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaAlberta T6G 2E9Canada

In this study,we provide evidence that oil sands process-affected waters(OSPW)contain factors that activate the antimicrobial and proinflammatory responses of immune cells.Specifically,using the murine macrophage RAW 264.7 cell line,we establish the bioactivity of two different OSPW samples and their isolated fractions.Here,we directly compared the bioactivity of two pilot scale demonstration pit lake(DPL)water samples,which included expressed water from treated tailings(termed the before water capping sample;BWC)as well as an after water capping(AWC)sample consisting of a mixture of expressed water,precipitation,upland runoff,coagulated OSPW and added freshwater.Significant inflammatory(i.***.macrophage activating)bioactivity was associated with the AWC sample and its organic fraction(OF),whereas the BWC sample had reduced bioactivity that was primarily associated with its inorganic fraction(IF).Overall,these results indicate that at non-toxic exposure doses,the RAW 264.7 cell line serves as an acute,sensitive and reliable biosensor for the screening of inflammatory constituents within and among discrete OSPW samples.

关键词： OSPW Oil sands Tailings ponds Remediation Macrophages bioactivity Bioindicator Immunoecotoxicology

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Biocompatibility pathways and mechanisms for bioactive materials:The bioactivity zone

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Bioactive Materials 2022年第4期7卷 306-322页

作者： David F.Williams Wake Forest Institute of Regenerative Medicine 391 Technology Way.Winston-SalemNorth Carolina27101USA

This essay analyzes the scientific evidence that forms the basis of bioactive materials,covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of biomaterials.This is a detailed assessment of performance in areas such as bone-induction,cell adhesion,immunomodulation,thrombogenicity and antimicrobial behavior.bioactivity is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host tissue.Although the term‘bioactive material’is widely used and has a well understood general meaning,it would be useful now to concentrate on this interfacial region,considered as‘the bioactivity zone’.bioactivity phenomena are either due to topographical/micromechanical characteristics,or to biologically active species that are presented in the bioactivity zone.Examples of topographical/micromechanical effects are the modulation of the osteoblast-osteoclast balance,nanotopographical regulation of cell adhesion,and bactericidal nanostructures.Regulation of bioactivity by biologically active species include their influence,especially of metal ions,on signaling pathways in bone formation,the role of cell adhesion molecules and bioactive peptides in cell attachment,macrophage polarization by immunoregulatory molecules and antimicrobial peptides.While much experimental data exists to demonstrate the potential of such phenomena,there are considerable barriers to their effective clinical translation.This essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials,especially when the material is modified in a manner designed to specifically induce that activity.

关键词： bioactivity Host response Biomaterial Medical technology Cell signaling

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Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation

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Journal of Materials Science & Technology 2022年第5期100卷 137-149页

作者： Sen Yu Zhe Yu Dagang Guo Hui Zhu Minghua Zhang Jianye Han Zhentao Yu Yemin Cao Gui Wang State Key Laboratory for Mechanical Behavior of Materials School of Material Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Shaanxi Key Laboratory of biomedical metallic materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016China Orthopedics Oncology Institute of Chinese PLA Tangdu HospitalAir Force Medical UniversityXi’an 710038China Shanghai Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Centre for Advanced Materials Processing and Manufacturing(AMPAM) The University of QueenslandSt LuciaQLD 4072Australia

The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte containing calcium and phosphate,a hydrothermal treatment enabled secondary microporous hydroxyapatite(HA)coating,and a further bone morphogenetic protein-2(BMP-2)loading treatment through immersion and freeze-drying.The treatment led to an orderly secondary microporous coating containing HA nano-particles and evenly distributed BMP-2 in the porous coatings.As a result,osteoblasts could adhere and grow well on the coatings with a high cell adhesion rate and cell functional activity.The in-situ shear testing indicated that the interfacial strength had been enhanced significantly.Improvement of the bond formation and osseointegration with the titanium implant is attributed to increased surface area for the cell to attach,creating voids for the cell to grow in,and activating titanium surface by introducing bioactive ingredients such as HA and BMP-2.

关键词： Graded porosity titanium Secondary microporous bioactivity Ti3Zr2Sn3Mo25Nb alloy Interface binding strength

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bioactivity analysis of the Ta(Ⅴ) doped SiO2–Ca O–Na2O–P2O5 ceramics prepared by solid state sintering method

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Progress in Natural Science:Materials International 2016年第1期26卷 41-48页

作者： Rehana Zia Madeeha Riaz Nida ul nasir Farhat Saleemi Zora Kayani Safia Anjum Farooq Bashir Tousif Hussain Department of Physics Lahore College for Women University 2. Government College for Women University 3. CASP Government College

The main objective of the study was to control the degradation rate of material at a higher degradation rate improving the chemical stability of the material. Ta is known to have good chemical resistance, biocompatibility and show no adverse biological response. In the present study, Si O–NaO–Ca O–PObioceramics with different TaOcontents was prepared by solid state sintering method at 1000 °C. The as-sintered ceramics were subjected to immersion studies in stimulated body fluid(SBF) for 21 days under static condition and characterized by XRD, FTIR, SEM, and AAS. The findings of the research indicate that the addition of TaOcontrolled degradability, and all samples showed sufficient bioactivity.

关键词： Crystallization bioactivity Ta2O5 Degradation rate Bioceramic

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Advances in chemistry and bioactivity of the genus Erythroxylum

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Natural Products and Bioprospecting 2022年第1期12卷 179-198页

作者： Yulian Lv Tian Tian Yong-Jiang Wang Jian-Ping Huang Sheng-Xiong Huang State Key Laboratory of Phytochemistry and Plant Resources in West China CAS Center for Excellence in Molecular Plant SciencesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Erythroxylum P.Browne is the largest and most representative genus of Erythroxylaceae family.It contains approxi-mately 230 species that are mainly distributed in tropical and subtropical regions.Some species in this genus,such as E.monogynum and E.coca,have been used as folk medicines in India or South America for a long history.It is well known that Erythroxylum plants are rich in tropane alkaloids,and the representative member cocaine shows remarka-ble activity in human central nervous system.However,many other types of active compounds have also been found in Erythroxylum along with the broadening and deepening of phytochemical research.To date,a total of 383 com-pounds from Erythroxylum have been reported,among which only 186 tropane alkaloids have been reviewed in 2010.In this review,we summarized all remained 197 compounds characterized from 53 Erythroxylum species from 1960 to 2021,which include diterpenes,triterpenes,alkaloids,flavonoids,and other derivates,providing a comprehensive overview of phytoconstituents profile of Erythroxylum plants.In addition,the biological activities of representative phytochemicals and crude extracts were also highlighted.

关键词： Erythroxylum Natural products Phytoconstituent bioactivity

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Mulberry Diels-Alder-type adducts:isolation,structure,bioactivity,and synthesis

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Natural Products and Bioprospecting 2022年第1期12卷 442-504页

作者： Si-Yuan Luo Jun-Yu Zhu Ming-Feng Zou Sheng Yin Gui-Hua Tang School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

Mulberry Diels-Alder-type adducts(MDAAs)are unique phenolic natural products biosynthetically derived from the intermolecular[4+2]-cycloaddition of dienophiles(mainly chalcones)and dehydroprenylphenol dienes,which are exclusively distributed in moraceous plants.A total of 166 MDAAs with diverse skeletons have been isolated and identified since 1980.Structurally,the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups(Types A−H),while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs(Type I).These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures,remarkable biological activities,and synthetic challenges.The present review provides a comprehensive summary of the structural properties,bioactivities,and syntheses of MDAAs.Cited references were collected between 1980 and 2021 from the SciFinder,Web of Science,and China National Knowledge Internet(CNKI).

关键词： Mulberry Diels-Alder-type adducts MDAAs Natural products bioactivity Synthesis

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bioactivity of quaternary glass prepared from bentonite clay

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Journal of Advanced Ceramics 2016年第1期5卷 47-53页

作者： Luqman A.ADAMS Enobong R.ESSIEN Department of Chemistry University of Lagos Nigeria Department of Chemical Sciences Bells University of Technology P.M.B 1015 Ota Ogun Nigeria

Alkoxysilane precursors are the most widely used silica source for sol–gel preparation of silicate-based bioactive glass. However, due to their high cost, alternative sources such as bentonite clay are desirable. In the present work, bentonite clay was reacted with sodium hydroxide (NaOH) to extract sodium metasilicate (Na2SiO3). The obtained Na2SiO3 was converted to gel which was then sintered at 950 ℃ for 3 h to give the bioactive glass in the quaternary composition SiO2–NaO–CaO–P2O5. The resulting glass was incubated in simulated body fluid (SBF) for 0–7 days to evaluate the bioactivity. Furthermore, glass samples were characterized before and after SBF study by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Results obtained showed the presence of Na2Ca2Si3O9 (combeite) crystal as the major crystalline phase and the formation of hydroxyapatite (HA) and hydroxycarbonated apatite (HCA) on the surface of the glass after immersion in SBF. The material showed potentials for application as scaffold in bone tissue repair.

关键词： bentonite clay bioactivity alkoxysilane hydroxyapatite (HA) bone repair

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A brief overview of classical natural product drug synthesis and bioactivity

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Organic Chemistry Frontiers 2022年第2期9卷 517-571页

作者： Gen Li Mingliang Lou Xiangbing Qi aNational Institute of Biological Sciences(NIBS) 7 Science Park Road ZGC Life Science ParkBeijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 100084China

Traditional medicines consisting of compounds derived from natural organisms have been used for human health care worldwide since ancient times.Since the last century,huge numbers of bioactive natural entities with diverse chemical scaffolds have been discovered,and some have been explored as clinical medications to treat various diseases.The advent of modern technologies has promoted the discovery of natural product-based pharmaceutical agents.The synthesis of natural products not only paves the way to confirm their molecular structures but also offers the structural modification opportunity to rationally optimize the drug-likeness parameters and evaluate the bioactivity of analogs.By providing a brief overview of a miscellaneous collection of complex natural products synthesis and the efforts of the structure–activity relationship,the present report aims to highlight the impact of chemical synthesis in natural product generation,diversification,bioactivity evaluation,and natural product-based drug development.

关键词： synthesis bioactivity rational

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Ethnopharmacology,chemodiversity,and bioactivity of Cephalotaxus medicinal plants

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Chinese Journal of Natural Medicines 2021年第5期19卷 321-338页

作者： HAO Da-Cheng HOU Xu-Dong GU Xiao-Jie XIAO Pei-Gen GE Guang-Bo Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Cephalotaxus is the only genus of Cephalotaxaceae family,and its natural resources are declining due to habitat fragmentation,excessive exploitation and destruction.In many areas of China,folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison,many of which are cancer.Not only among Han people,but also among minority ethnic groups,Cephalotaxus is used to treat various diseases,e.g.,cough,internal bleeding and cancer in Miao medicine,bruises,rheumatism and pain in Yao medicine,and ascariasis,hookworm disease,scrofula in She medicine,etc.Medicinal values of some Cephalotaxus species and compounds are acknowledged officially.However,there is a lack of comprehensive review summarizing the ethnomedicinal knowledge o f Cephalotaxus,relevant medicinal phytometabolites and their bioactivities.The research progresses in ethnopharmacology,chemodiversity,and bioactivities of Cephalotaxus medicinal plants are reviewed and commented here.Knowledge gaps are pinpointed and future research directions are suggested.Classic medicinal books,folk medicine books,herbal manuals and ethnomedicinal publications were reviewed for the genus Cephalotaxus(Sanjianshan in Chinese).The relevant data about ethnobotany,phytochemistry,and pharmacology were collected as comprehensively as possible from online databases including Scopus,NCBI PubMed,Bing Scholar,and China National Knowledge Infrastructure(CNKI).44 Cephalotaxus"',and the respective species name were used as keywords in database search.The obtained articles of the past six decades were collated and analyzed.Four Cephalotaxus species are listed in the official medicinal book in China.They are used as ethnomedicines by many ethnic groups such as Miao,Yao,Dong,She and Han.Inspirations are obtained from traditional applications,and Cephalotaxus phytometabolites are developed into anticancer reagents.Cephalotaxine-type alkaloids,homoerythrina-type alkaloids and homoharringtonine(HHT)are abundant in Cephalotaxus,e.g.,C.lanceolata,C.fortunei var.alpina,C.

关键词： Cephalotaxus Ethnomedicine Chemodiversity Alkaloids bioactivity Pharmacology

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