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imaging of Degenerative Pathologies of the Lumbar Spine: Professional Habits in Some Hospitals in Cameroon

Journal of Biosciences and Medicines 2021年第8期9卷 143-154页

作者： Mohamadou Aminou Yannick Onana Richard Mbozo’o Nvondo Samuel Neossi Nguena Mathurin Aissata Bintou Moctar Ngo Nyemeg Celenaie Claude Mbo Amvene Jeremie department of radiology and Medical imaging Faculty of Medicine and Biomedical Sciences University of Ngaoundere Ngaoundere Cameroon department of biomedical Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon department of radiology and Medical imaging Maroua Regional Hospital Maroua Cameroon department of radiology and Medical imaging Laquintinine Hospital Douala Cameroon

Background: The lumbar spine is the portion most frequently involved in degenerative pathologies. Everyone will suffer one day from “low back pain”. These pathologies are very frequent: epidemiological studies have shown that 65% to 90% of the general population could be affected by low back pain (lumbago) which could become chronic at acertain stage or could be complicated (2% to 4%) of cases could end up affecting nerve roots. Chronic low back pain causes a major public health problem in terms of morbidity and socioeconomic repercussions. Purpose: The overall purpose of this study is to evaluate the professional habits of exam applicants in case of degenerative pathologies of the lumbar spine, to Appreciate the knowledge of clinicians on the usefulness of medical imaging techniques in the event of suspicion of a degenerative pathology of the lumbar spine and finally to evaluate if the professional habits of requesting examinations in Cameroon comply with the Recommendations for Clinical Practice. Methods: A cross-sectional and descriptive study was used and was based on questionnaires distributed to those practitioners who requested for these diagnostic medical imaging studies and procedures at Yaoundé General Hospital (HGY), Yaoundé Central Hospital, La Cathédrale Medical center, Yaoundé University Teaching Hospital, the Douala General Hospital, the Laquintinie Hospital of Douala, the Military Hospital of Douala, the Daniel Muna Memorial Clinic of Douala, the International center for Clinical and Medicine imaging, the Ngaoundere Regional Hospital and the Protestant Hospital of Ngaoundere (HPN), from April 2020 to March 2021. Data collected was processed and analyzed via Epi Info version 12.0 and the statistical test used for correlation was Chi2. Results: 137 practitioners were retained among whom, 90 were male and 47 females, their average age being 46 years with working experience less than 5 y

关键词： Lumbar Spine Medical imaging Degenerative Pathologies Professional Habits Recommendations

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Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform

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National Science Review 2021年第6期8卷 148-159页

作者： Xiang Ling Zhaokui Jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong ProvinceInstitute of Microscale OptoelectronicsShenzhen University Guangdong Provincial Key Laboratory of biomedical Measurements and Ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen University department of Quantum and Energy Materials International Iberian Nanotechnology Laboratory (INL) departments of radiology and Medical Physics University of Wisconsin-Madison

Photothermal nanotheranostics, especially in the near infrared II（NIR-II） region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II ***-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSexnano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se（x = 0.43）. We have also discovered that the as-prepared TeSexnano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency（77.2%）,64Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions.

关键词： nanomedicine nano-alloys photothermal therapy cancer nanotheranostics biomedical imaging

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Hepatocellular carcinoma Liver imaging Reporting and Data Systems treatment response assessment: Lessons learned and future directions

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World Journal of Hepatology 2020年第10期12卷 738-753页

作者： Anum Aslam Richard Kinh Gian Do Avinash Kambadakone Bradley Spieler Frank H Miller Ahmed M Gabr Resmi A Charalel Charles Y Kim David C Madoff Mishal Mendiratta-Lala department of radiology University of MichiganAnn ArborMI 48019United States department of radiology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065United States Abdominal imaging and Interventional radiology Harvard Medical SchoolMassachusetts General HospitalBostonMA 02114United States department of radiology Louisiana State University Health Sciences CenterNew OrleansLA 70112United States department of radiology Northwestern University Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611United States department of Interventional radiology OHSU and Tanta UniversityEgyptPortlandOR 97239United States department of radiology Weill Cornell MedicineNew YorkNY 10065United States department of radiology Duke University Medical CenterDuke UniversityDurhamNC 27710United States department of radiology and biomedical imaging Yale School of MedicineNew HavenCT 06520United States School of Medicine 1500 East Medical Center DriveUniversity of MichiganAnn ArborMI 48109United States

Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence *** are a multitude of evolving treatment options,including locoregional therapies which can be used alone,in combination with each other,or in combination with systemic *** treatment options have shown to be effective in achieving remission,controlling tumor progression,improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage *** locoregional therapy(LRT),it is crucial to provide treatment response assessment to guide management and liver transplant ***,Liver imaging Reporting and Data Systems(LI-RADS)Treatment Response Algorithm(TRA)was created to provide a standardized assessment of HCC following *** TRA provides a step by step approach to evaluate each lesion independently for accurate tumor *** this review,we provide an overview of different locoregional therapies for HCC,describe the expected post treatment imaging appearance following treatment,and review the LI-RADS TRA with guidance for its application in clinical *** to other publications,we will also review emerging literature supporting the use of LI-RADS for assessment of HCC treatment response after LRT.

关键词： Hepatocellular carcinoma Liver imaging Reporting and Data Systems Treatment Response Algorithm Locoregional therapy Liver imaging Reporting and Data Systems Treatment Response equivocal Arterial phase hyper enhancement Stereotactic body radiotherapy

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Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage

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Neuroscience Bulletin 2020年第9期36卷 985-996页

作者： Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang Tanikawa Hiromi Jiaxing Tan Lichi Zhang Weijun Tang Dinggang Shen Institute for Medical imaging Technology Shanghai Jiao Tong UniversityShanghai 200030China department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200030China Neurosurgical Institute of Fudan University Shanghai Clinical Medical Center of NeurosurgeryShanghai Key Laboratory of Brain Function Restoration and Neural RegenerationShanghai 200030China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers center for Brain Science School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghai 200030China department of radiology Huashan HospitalFudan UniversityShanghai 200030China department of radiology and biomedical Research imaging center University of North Carolina at Chapel HillChapel HillNC 27599USA department of Brain and Cognitive Engineering Korea UniversitySeoul 02841Republic of Korea

Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the ***,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and *** non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is *** studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid *** applied a novel machine-learning method to find the most discriminative features from the multi-modal ***,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of *** experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual *** regression model has high potential for the evaluation of consciousness in clinical practice.

关键词： Hydrocephalus Disorder of consciousness Structural imaging Feature selection Regression

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CM-101:靶向Ⅰ型胶原蛋白测定肝纤维化的MR成像探针

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国际医学放射学杂志 2018年第4期 474-474页

作者： C.T.Farrar E.M.Gale R.Kennan I.Ramsay R.Masia G.Arora 何博 athinoula A. martinos center for biomedical imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical School

目的评价新型靶向Ⅰ型胶原蛋白MR探针CM-101的生物分布、代谢和药代动力学,并进一步评估该探针在动物模型中帮助量化肝纤维化的能力。材料与方法用质谱法测量分析大鼠中CM-101的生物分布、药代动力学和稳定性。动物分为2组,胆管结扎(BDL... 详细信息

目的评价新型靶向Ⅰ型胶原蛋白MR探针CM-101的生物分布、代谢和药代动力学,并进一步评估该探针在动物模型中帮助量化肝纤维化的能力。材料与方法用质谱法测量分析大鼠中CM-101的生物分布、药代动力学和稳定性。动物分为2组,胆管结扎(BDL)组和假手术组,所有动物术后19 d使用1.5 T临床MR成像设备进行扫描。实验组小鼠每周2次腹腔注射四氯化碳(CCl4)橄榄油混合物,对照组注射空白橄榄油,连续注射10周,并在CCl4注射前和最后一次注射后1周分别行7.0 T MR成像扫描,采集CM-101(10μmol/kg)注射前后的影像。注射CM-101后肝脏和肌肉组织之间的对比噪声比的变化(ΔCNR)用于量化肝纤维化。肝组织行天狼星红染色和羟脯氨酸含量分析。本实验研究获得动物保护研究机构小组委员会批准。结果 CM-101具有快速血浆清除率,主要经大鼠肾脏快速清除[半衰期:(6.8±2.4)min]。CM-101注射24 h后,体内组织钆含量低[<(3.9%±0.6%)ID/g],第14天时钆含量降低为1/10[<(0.33%±0.12%)ID/g],骨吸收量可忽略不计[在第1天和第14天分别显示为(0.07%±0.02%)ID/g和(0.010%±0.004%)ID/g]。与假手术组相比,BDL组ΔCNR显著升高(13.6±3.2∶5.2±1.0,P<0.001),与基线水平比较,CCl4注射后ΔCNR也显著升高(18.3±6.5∶5.2±1.0,P<0.001)。结论 CM-101具有快速血浆清除率和全身清除率,骨或组织中钆沉积量极少基本可忽略;BDL大鼠和CCl4诱导大鼠,利用CM-101能可靠地检测肝纤维化。

关键词： Ⅰ型胶原蛋白肝纤维化 MR CM-101

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imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles

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Advances in Molecular imaging 2012年第4期2卷 31-37页

作者： Aristarchos Papagiannaros Valeria Righi George G. Day Laurence G. Rahme Philip K. Liu Alan J. Fischman Ronald G. Tompkins A. Aria Tzika athinoula A. martinos center of biomedical imaging Department of Radiology Massachusetts General Hospital Boston USA department of Surgery Massachusetts General Hospital Harvard Medical School Boston USA Molecular Surgery Laboratory Department of Surgery Massachusetts General Hospital and Shriners Burns Institute Harvard Medical School and Massachusetts General Hospital Boston USA NMR Surgical Laboratory Department of Surgery Massachusetts General Hospital and Shriners Burns Institute Harvard Medical School Boston USA

MR imaging of gene transcription is important as it should enable the non-invasive detection of mRNA alterations in disease. A range of MRI methods have been proposed for in vivo molecular imaging of cells based on the use of ultra- small super-paramagnetic iron oxide (USPIO) nanoparticles and related susceptibility weighted imaging methods. Al-though immunohistochemistry can robustly differentiate the expression of protein variants, there is currently no direct gene assay technique that is capable of differentiating established to differentiate the induction profiles of c-Fos mRNA in vivo. To visualize the differential FosB gene expression profile in vivo after burn trauma, we developed MR probes that link the T2* contrast agent [superparamagnetic iron oxide nanoparticles (SPION)] with an oligodeoxynucleotide (ODN) sequence complementary to FosB mRNA to visualize endogenous mRNA targets via in vivo hybridization. The presence of this SPION-ODN probe in cells results in localized signal reduction in T2*-weighted MR images, in which the rate of signal reduction (R2*) reflects the regional iron concentration at different stages of amphetamine (AMPH) exposure in living mouse tissue. Our aim was to produce a superior contrast agent that can be administered using sys- temic as opposed to local administration and which will target and accumulate at sites of burn injury. Specifically, we developed and evaluated a PEGylated lipid coated MR probe with ultra-small super-paramagnetic iron oxide nanoparti- cles (USPION, a T2 susceptibility agent) coated with cationic fusogenic lipids, used for cell transfection and gene de- livery and covalently linked to a phosphorothioate modified oligodeoxynucleotide (sODN) complementary to c-Fos mRNA (SPION-cFos) and used the agent to image mice with leg burns. Our study demonstrated the feasibility of monitoring burn injury using MR imaging of c-Fos transcription in vivo, in a clinically relevant mouse model of burn injury for the first ti

关键词： Positive Contrast Transverse Relaxation in the Rotating Frame (T2r) Superparamagnetic Iron-Oxide (Uspio) Burn Skeletal Muscle C-Fos

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Derivatization based on tetrazine scaffolds:synthesis of tetrazine derivatives and their biomedical applications

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Organic Chemistry Frontiers 2022年第2期9卷 481-498页

作者： Hongbao Sun Qinghe Xue Chang Zhang Haoxing Wu Ping Feng Huaxi MR Research center(HMRRC) Department of RadiologyFrontiers Science Center for Disease-related Molecular NetworkNational Clinical Research Center for GeriatricsFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China Clinical Trial center West China Hospital of Sichuan UniversityChengdu 610041China

Bioorthogonal chemistry is widely used in biological systems and has been trialed in patients,attracting a lot of attention in this ***-based bioorthogonal reactions are essential in chemical biology applications,including cellular labeling,live-cell imaging,diagnosis,drug release,and oncotherapy,due to their tunable rapid reaction kinetics and unique fluorogenic ***,the scope of de novo tetrazine synthesis is restricted due to the limited supply of commercial starting ***,derivatization based on tetrazine scaffolds has been used to synthesize various tetrazine derivatives to enhance the applications of tetrazine bioorthogonal ***,the recent advances in tetrazine scaffold-based derivatizations,including tetrazine skeletons,aromatic substituents and alkyl substituents of tetrazines,have been *** advantages and limitations of the derivatization methods and applications of the developed tetrazine derivatives in bioorthogonal chemistry have also been highlighted.

关键词： materials. synthesis substituent

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Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study

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Neural Regeneration Research 2021年第3期16卷 531-536页

作者： Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu department of radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina department of radiology the Affiliated Zhuzhou Hospital of Xiangya College of MedicineCentral South UniversityZhuzhouHunan ProvinceChina Lister Hill National center for biomedical Communication National Library of MedicineBethesdaMDUSA Medical Psychological center the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch *** underlying neural mechanisms of congenital amusia have been actively ***,little attention has been paid to the changes in the motor rain within congenital *** this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control *** found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback *** found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia *** conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital *** evidence supports the view that sensorimotor coupling plays an important role in memory and musical *** study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(***20180101GZ01)on February 9,2019.

关键词： congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis

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Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

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National Science Review 2020年第9期7卷 1428-1436页

作者： Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen University Guangdong Provincial Key Laboratory of biomedical imaging and Guangdong Provincial Engineering Research center of Molecular imaging The Fifth Affiliated HospitalSun Yat-sen University center for Interventional Medicine The Fifth Affiliated HospitalSun Yat-sen University department of Pharmacy The Fifth Affiliated HospitalSun Yat-sen University department of Respiratory and Critical Care Medicine Sun Yat-sen Memorial HospitalSun Yat-sen University Clinical Research center Office The Fifth Affiliated HospitalSun Yat-sen University department of radiology The Fifth Affiliated HospitalSun Yat-sen University department of Stomatology The Fifth Affiliated HospitalSun Yat-sen University department of Hematology The Fifth Affiliated HospitalSun Yat-sen University department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen University

Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19. In this multicenter prospective observational study, we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces. Eligible patients received chloroquine phosphate500 mg, orally, once(half dose) or twice(full dose) daily. Patients treated with non-chloroquine therapy were included as historical controls. The primary endpoint is the time to undetectable viral RNA. Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14, hospitalization time, duration of fever, and adverse events. A total of 197 patients completed chloroquine treatment, and 176 patients were included as historical controls. The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days; 95% CI-6.0 to-4.0). The duration of fever is shorter in chloroquine(geometric mean ratio 0.6; 95% CI 0.5 to 0.8). No serious adverse events were observed in the chloroquine group. Patients treated with half dose experienced lower rate of adverse events than with full dose. Although randomized trials are needed for further evaluation, this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 treatment chloroquine

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Magnetic resonance imaging in personalized medicine

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Science China(Life Sciences) 2017年第1期60卷 1-4页

作者： Xiaoying Wang Xiaohong Joe Zhou radiology department Peking University First Hospital center for Magnetic Resonance Research and departments of radiology Neurosurgery and BioengineeringUniversity of Illinois at Chicago

Continued biomedical advances and increased demands on quality health care have led to a new era of personalized medicine--a concept of medicine that uses specific infor- mation to an individual to help diagnose disease, plan treatment, assess treatment efficacy, and/or predict progno- sis. This concept has evolved from the idea of ＂pa- tient-centered care＂, which intends to shift the focus of health care from diseases to patients （Abujudeh et al., 2016）. Medical imaging is essential in the practice of mod- em medicine, and its role in personalized medicine has nev- er been greater. In particular, magnetic resonance （MR） imaging--a versatile and growing medical imaging modal- ity--is at the forefront leading the transformation from tra- ditional practice to personalized medicine. In 2001, a survey of leading physicians ranked MR imaging as well as CT scan as the most important medical innovations since 1980s （Fuchs et al., 2001）. Over the past four decades, MR imag- ing has shown an explosive growth and become the modal- ity of choice for assessment of the central nervous system,

关键词：个性化医疗磁共振成像生物医学中枢神经系统医学影像学医疗保健现代医学医疗成像

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