检索结果-南通市图书馆

Mechanisms of Helicobacter pylori antibiotic resistance:An updated appraisal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2011年第3期2卷 35-41页

作者： Vincenzo De Francesco Angelo Zullo Cesare Hassan Floriana Giorgio Rosa Rosania Enzo Ierardi Section of Gastroenterology Department of Medical SciencesUniversity of Foggia Gastroenterology and Digestive endoscopy 'Nuovo Regina Margherita' Hospital

Helicobacter pylori(H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin,metronidazole,quinolones,amoxicillin and tetracycline are accurately detailed(point mutations,redox intracellular potential,pump efflux systems,membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms,the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap,feasible and reliable laboratory test to predict the outcome of a therapeutic scheme.

关键词： Helicobacter pylori Clarithromycin Metronidazole Levofloxacin Amoxicillin Tetracycline Resistance Antibiotic Point mutation

Gastric cancer in 2022:Is there still a role for endoscopic ultrasound?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal endoscopy 2023年第1期15卷 1-9页

作者： Gemma Rossi Maria Chiara Petrone Andrew J Healey Paolo Giorgio Arcidiacono Pancreato-Biliary endoscopy and Endosonography Division Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita Salute San Raffaele UniversityMilan 20132Italy Department of Clinical Surgery University of EdinburghRoyal Infirmary of EdinburghEdinburgh EH164SAUnited Kingdom

Gastric cancer(GC)represents the fourth leading cause of cancer death worldwide and many factors can influence its development(diet,geographic area,genetic,Helicobacter pylori or Epstein-Barr virus infections).High quality endoscopy represents the modality of choice for GC *** correct morphologic classification during a high-resolution endoscopy is fundamental for oncologic diagnosis,staging and therapeutic *** its initial introduction in clinical practice the endoscopic ultrasound(EUS)has been considered a valuable tool for tumor(T-)and lymph nodes(N-)staging also in GC,in order to establish the best therapeutic strategy for the patient(e.g.,upfront surgery vs neoadjuvant treatments).EUS tools as elastography,Doppler and contrast administration can improve diagnosis mainly in case of malignant lymph node *** has a marginal role in disease staging but has a fundamental role in case of a pre-endoscopic resection management and in the new era of endoscopic mucosal resection or submucosal dissection as minimally invasive *** and locoregional staging of GC with EUS are a method of inarguable value for the assessment of gastric wall involvement and presence of infiltrated paragastric lymph *** can also have a role in disease restaging in those patients who have undergone neoadjuvant *** can also have a role in the advanced phases of the disease,in facilitating palliative,minimallyinvasive treatments,such as gastroenterostomy or biliary *** review intends to discuss the modern role of EUS in GC topic.

关键词： Gastric cancer Endoscopic ultrasound Endoscopic resection Neoadjuvant chemotherapy therapeutic endoscopic ultrasound

Capsule endoscopy in neoplastic diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第34期14卷 5245-5253页

作者： Marco Pennazio Emanuele Rondonotti Roberto de Franchis Division of Gastroenterology 2 Department of Gastroenterology and Clinical Nutrition S. Giovanni A.S. Hospital University of Milan IRCCS Policlinico MangiagalliRegina Elena Foundation Gastroenterology and Gastrointestinal Endoscopy Unit University of Milan IRCCS Policlinico MangiagalliRegina Elena Foundation Gastroenterology and Gastrointestinal Endoscopy Unit

Until recently, diagnosis and management of small-bowel tumors were delayed by the diffi culty of access to the small bowel and the poor diagnostic capabilities of the available diagnostic techniques. An array of new methods has recently been developed, increasing the possibility of detecting these tumors at an earlier stage. Capsule endoscopy (CE) appears to be an ideal tool to recognize the presence of neoplastic lesions along this organ, since it is non-invasive and enables the entire small bowel to be visualized. High- quality images of the small-bowel mucosa may be captured and small and ? at lesions recognized, without exposure to radiation. Recent studies on a large population of patients undergoing CE have reported small-bowel tumor frequency only slightly above that reported in previous surgical series (range, 1.6%-2.4%) and have also confirmed that the main clinical indication to CE in patients with small-bowel tumors is obscure gastrointestinal (GI) bleeding. The majority of tumors identified by CE are malignant; many were unsuspected and not found by other methods. However, it remains difficult to identify pathology and tumor type based on the lesion’s endoscopic appearance. Despite its limitations, CE provides crucial information leading in most cases to changes in subsequent patient management. Whether the use of CE in combination with other new diagnostic (MRI or multidetector CT enterography) and therapeutic (Push- and-pull enteroscopy) techniques will lead to earlier diagnosis and treatment of these neoplasms, ultimately resulting in a survival advantage and in cost savings,remains to be determined through carefully-designed studies.

关键词：胶囊内窥镜检查法消化道出血消化系统疾病息肉病

First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第43期26卷 6710-6769页

作者： Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi Gastroenterology and endoscopy Department Ibrahim Bin Hamad Obaid Allah HospitalMinistry of Health and PreventionRas Al KhaimanUnited Arab Emirates Department of Gastroenterology Sheikh Shakbout Medical CityAbu DhabiUnited Arab Emirates Department of Gastroenterology Valiant ClinicDubaiUnited Arab Emirates Department of Gastroenterology and endoscopy American HospitalDubaiUnited Arab Emirates Gastroenterology and endoscopy Unit Al Zahra HospitalDubaiUnited Arab Emirates Gastroenterology Division Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Digestive Disease Unit Rashid HospitalDubaiUnited Arab Emirates Digestive Disease Institute Cleveland ClinicAbu DhabiUnited Arab Emirates Department of Gastroenterology Mediclinic City HospitalDubaiUnited Arab Emirates Gastroenterology and Hepatology Tawam HospitalAl AinUnited Arab Emirates Department of Gastroenterology The Pennine Acute Hospitals NHS TrustManchester Academic Health SciencesUniversity of ManchesterManchester M85RBUnited Kingdom

Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal *** incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is *** progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with *** guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based *** up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications.

关键词： Ulcerative colitis Crohn’s disease Infliximab Adalimumab Vedolizumab Ustekinumab Tofacitinib

IN VIVO NEAR-INFRAREDFLUORESCENCEIMAGING OF HUMANCOLONADENOCARCINOMABY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEDMUCIN

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DACOSTA YING TANG TUULA KALLIOMAKI RAYMOND M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARCON BRIAN C.WILSON Division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada Department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA Division of Clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada Campbell Family Institute for Breast Cancer Research University Health Network/Ontario Cancer Institute Department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital Center for therapeutic endoscopy and Endoscopic Oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

Role of endoscopy in the management of acute diverticular bleeding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第13期14卷 1981-1983页

作者： Charalampos Pilichos Emmanouil Bobotis Department of Digestive endoscopy Sismanogleion General Hospital Athens 15126 Greece Department of Surgery Sismanogleion General Hospital Athens 15126 Greece

Colonic diverticulosis is one of the most common causes of lower gastrointestinal bleeding. endoscopy is not only a useful diagnostic tool for localizing the bleeding site, but also a therapeutic modality for its management. To date, haemostatic methods have included adrenaline injection, mechanical clipping, thermal and electrical coagulation or combinations of them. The results of all published data are herein reviewed.

关键词：憩室病内窥镜检查法治疗肠疾病

Helicobacter pylori and functional dyspepsia: An unsolved issue?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第27期20卷 8957-8963页

作者： Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici Raffaele Manta Silverio Tomao Bruno Annibale Dino Vaira Gastroenterology and Digestive endoscopy "Nuovo Regina Margherita" Hospital Gastroenterology Unit "Riuniti" Hospital Digestive endoscopy Unit "IRCCS Istituto Clinico Humanitas" 20089 Milan Italy Gastroenterology and endoscopy Unit "Nuovo S Agostino" Hospital Oncology Unit "SM Goretti" Hospital Latina "Sapienza" University Department of Digestive and Liver Diseases "Sant’Andrea" Hospital "Sapienza" University Department of Internal Medicine and Gastroenterology University of Bologna

Patients with Helicobacter pylori(H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small(10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this

关键词： Helicobacter pylori Dyspepsia Symptoms Therapy Pat

advanced endoscopic submucosal dissection with traction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal endoscopy 2014年第7期6卷 286-295页

作者： Hiroyuki Imaeda Naoki Hosoe Kazuhiro Kashiwagi Tai Ohmori Naohisa Yahagi Takanori Kanai Haruhiko Ogata Department of General Internal Medicine Saitama Medical UniversitySaitama 350-0495Japan Center for Diagnostic and therapeutic endoscopy School of MedicineKeio University108-8345 TokyoJapan Division of Research and Development for Minimally Invasive Treatment Cancer CenterSchool of MedicineKeio University108-8345 TokyoJapan Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineKeio University108-8345 TokyoJapan

Endoscopic submucosal dissection(ESD)has been established as a standard treatment for early stage gastric cancer(EGC)in Japan and has spread *** has been used not only for EGC but also for early esophageal and colonic ***,ESD is as-sociated with several adverse events,such as bleeding and perforation,which requires more *** tissue tension and clear visibility of the tissue to be dissected are important for effective and safe *** ESD methods using traction have been devel-oped,such as clip-with-line method,percutaneous trac-tion method,sinker-assisted method,magnetic anchor method,external forceps method,internal-traction method,double-channel-scope method,outerroute method,double-scope method,endoscopic-surgical-platform,and robot-assisted *** method has both advantages and *** endos-copy,enabling ESD with a traction method,will become more common due to advances in *** thenear future,simple,noninvasive,and effective ESD us-ing traction is expected to be developed and become established as a worldwide standard treatment for superficial gastrointestinal neoplasias.

关键词： Endoscopic submucosal dissection Traction Early gastric cancer Early esophageal cancer Early colonic cancer

Sedation and monitoring for gastrointestinal endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal endoscopy 2013年第2期5卷 47-55页

作者： Somchai Amornyotin Department of Anesthesiology and Siriraj Gastrointestinal endoscopy Center Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand

The safe sedation of patients for diagnostic or therapeutic procedures requires a combination of properly trained physicians and suitable ***,appropriate selection and preparation of patients,suitable sedative technique,application of drugs,adequate monitoring,and proper recovery of patients is *** goal of procedural sedation is the safe and effective control of pain and anxiety as well as to provide an appropriate degree of memory loss or decreased *** practices for gastrointestinal endoscopy(GIE) vary *** majority of GIE patients are ambulatory *** of this procedure requires a short ***,short acting,rapid onset drugs with little adverse effects and improved safety profiles are commonly *** present review focuses on commonly used regimens and monitoring practices in GIE *** article is to discuss the decision making process used to determine appropriate pre-sedation assessment,monitoring,drug selection,dose of sedative agents,sedation endpoint and post-sedation *** also reviews the current status of sedation and monitoring for GIE procedures in Thailand.

关键词： Sedation Monitoring Gastrointestinal endoscopy Sedatives Analgesics