Helicobacter pylori and functional dyspepsia: An unsolved issue?
Helicobacter pylori and functional dyspepsia: An unsolved issue?作者机构：Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital Gastroenterology Unit "Riuniti" Hospital Digestive Endoscopy Unit "IRCCS Istituto Clinico Humanitas" 20089 Milan Italy Gastroenterology and Endoscopy Unit "Nuovo S Agostino" Hospital Oncology Unit "SM Goretti" Hospital Latina "Sapienza" University Department of Digestive and Liver Diseases "Sant’Andrea" Hospital "Sapienza" University Department of Internal Medicine and Gastroenterology University of Bologna
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第27期
页 面：8957-8963页
核心收录：
主 题：Helicobacter pylori Dyspepsia Symptoms Therapy Pat
摘 要：Patients with Helicobacter pylori(H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small(10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this
维普期刊数据库