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Synthesis and characterization of reporter molecules embedded core-shell nanoparticles as SERS nanotags

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 94-103页

作者： Chloe Duffield Nana Lyu Yuling Wang Department of Molecular Sciences arc centre of excellence for nanoscale biophotonics Faculty of Science and Engineering Macquarie University SydneyNSW 2109Australia

Surface-enhanced Raman scattering(SERS)spectroscopy is presented as a sensitive and spe-cific molecular tool for clinical diagnosis and prognosis monitoring of various diseases including *** order for clinical application of SERS technique,an ideal method of bulk synthesis of SERS nanoparticles is necessary to obtain sensitive,stable and highly reproducible Raman *** this contribution,we determined the ideal conditions for bulk synthesis of Raman reporter(Ra)molecules embedded silver-gold core-shell nanoparticles(Au@Ra@AgNPs)using hydroquinone as reducing agent of silver *** using UV-Vis spectroscopy,Raman spectroscopy and transmission electron microscopy(TEM),we found that a 2∶1 ratio of silver nitrate to hydroquinone is ideal for a uniform silver coating with a strong and stable Raman *** stability testing of the optimized Au@Ra@AgNPs over a two-week period,these SERS nanotags were found to be stable with minimal signal change *** sta-bility of antibody linked SERS nanotags is also crucial for cancer and disease diagnosis,thus,we further conjugated the as-prepared SERS nanotags with anti-EpCAM antibody,in which the stability of bioconjugated SERS nanotags was tested over eight *** UV-Vis and SERS spectroscopy showed stable absorption and Raman signals on the anti-EpCAM conju-gated SERS nanotags,indicating the great potential of the synthesized SERS nanotags for future applications which require large,reproducible and uniform quantities in order for cancer biomarker diagnosis and monitoring.

关键词： surface-enhanced Raman spectroscopy gold nanoparticles Raman reporter mole-cules SERS nanotags and bioconjugation

Synthesis of strong SiV photoluminescent diamond particles on silica optical fiber by chemical vapor deposition

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Chinese Physics B 2018年第3期27卷 481-486页

作者： Zongchun Yang Yingshuang Mei Chengke Chen Yinlan Ruan Xiaojun Hu College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China arc centre of excellence in nanoscale biophotonics Institute of Photonics and Advanced SensingThe University of AdelaideAdelaideSA 5005Australia

The separated silicon-vacancy(SiV)photoluminescent diamond particles were synthesized on a silica optical fiber by hot filament chemical vapor deposition(HFCVD).The effects of the pre-treated method and chamber pressure on the microstructure and photoluminescence of the diamond particles were *** results show that the diamond particles are homogeneously distributed on the surface of the optical *** the chamber pressure increasing from 1.6 kPa to 3.5 kPa,the shape of the particles transforms from flake to circle,while the diamond particles cannot be deposited on the fiber with the pressure further increased to 4.5 *** samples synthesized under 2.5 kPa chamber pressure are composed of diamond particles with size around 200-400 nm,exhibiting stronger SiV photoluminescence with the width of around 6 nm.

关键词： diamond silicon vacancy photoluminescence optical fiber

On-chip structure-switching aptamer-modified magnetic nanobeads for the continuous monitoring of interferon-gamma ex vivo

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Microsystems & Nanoengineering 2019年第1期5卷 281-291页

作者： Guozhen Liu Chaomin Cao Shengnan Ni Shilun Feng Hui Wei Graduate School of Biomedical Engineering ARC Centre of Excellence in Nanoscale Biophotonics(CNBP)Faculty of EngineeringThe University of New South WalesSydneyNSW 2052Australia Australian centre for NanoMedicine UNSW SydneySydneyNSW 2052Australia International Joint Research Center for Intelligent Biosensor Technology and Health College of ChemistryCentral China Normal University430079 WuhanPR China School of Engineering Faculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia

Cytokines are cell signaling molecules that indicate the health status of the *** this study,we developed a microfluidic device integrated with structure-switching aptamers capable of continuously tracking the concentration of the cytokine interferon gamma(IFN-γ)in cell culture medium and blood ***,a ferrocene(Fc)-labeled structure-switching signaling aptamer with a hairpin structure targeting IFN-γwas immobilized on magnetic nanobeads by the strongest noncovalent interactions between streptavidin and *** aptamer-modified magnetic nanobeads were trapped on a customized microfluidic chip by a magnetic field to form the sensing *** binding of IFN-γcould trigger the hairpin structure of the aptamer to unfold,pushing Fc redox molecules away from the sensing interface and consequently switching off the electrochemical *** change in the redox current of Fc was quantitatively related to the concentration of IFN-γin a linear range of 10–500 pg mL^(−1)and with the lowest detection limit of 6 pgmL^(−1).This microfluidic device was specific to IFN-γin the presence of overabundant serum proteins and allowed the continuous monitoring of IFN-γwithout adding exogenous *** provided a universal point-of-care biosensing platform for the real-time detection of a spectrum of analytes.

关键词： beads structure magnetic

SERS Nanotags and Their Applications in Biosensing and Bioimaging

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Journal of Analysis and Testing 2018年第1期2卷 26-44页

作者： Wei Zhang Lianmei Jiang James APiper Yuling Wang Department of Molecular Sciences Macquarie UniversitySydneyNSW 2109Australia arc centre of excellence for nanoscale biophotonics(CNBP) Macquarie UniversitySydneyNSW 2109Australia Department of Physics and Astronomy Macquarie UniversitySydneyNSW 2109Australia

Owing to the unique advantages of surface enhanced Raman scattering(SERS)in high sensitivity,specificity,multiplexing capability and photostability,it has been widely used in many applications,among which SERS biosensing and bioimaging are the focus in recent *** successful applications of SERS for non-invasive biomarker detection and bioimaging under in vitro,in vivo and ex vivo conditions,offer significant clinical information to improve diagnostic and prognostic *** review provides recent developments and applications of SERS,in particular SERS nanotags in biosensing and bioimaging,describing case studies in which different types of biomarkers have been investigated,as well as outlining future challenges that need to be addressed before SERS sees both pathological and clinical use.

关键词： SERS Plasmonic nanostructure Nanotags Biosensing Bioimaging Biomarker

A Non-Singular Boundary Element Method for Interactions between Acoustical Field Sources and Structures

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Advances in Applied Mathematics and Mechanics 2023年第4期15卷 831-851页

作者： Qiang Sun Australian Research Council centre of excellence for nanoscale biophotonics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

Localized point sources(monopoles)in an acoustical domain are implemented to a three dimensional non-singular Helmholtz boundary element method in the frequency *** allows for the straightforward use of higher order surface elements on the boundaries of the *** will been shown that the effect of the monopole sources ends up on the right hand side of the resulting matrix *** carefully selected examples are studied,such as point sources near and within a concentric spherical core-shell scatterer(with theoretical verification),near a curved focusing surface and near a multi-scale and multi-domain acoustic lens.

关键词： Acoustic monopoles acoustic lens boundary integral method quadratic elements

Development of innovative tools for investigation of nutrient-gut interaction

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World Journal of Gastroenterology 2020年第25期26卷 3562-3576页

作者： Wei-Kun Huang Cong Xie Richard L Young Jiang-Bo Zhao Heike Ebendorff-Heidepriem Karen L Jones Christopher K Rayner Tong-Zhi Wu Adelaide Medical School Centre of Research Excellence in Translating Nutritional Science to Good Healththe University of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing School of Physical SciencesUniversity of AdelaideAdelaideSA 5005Australia The arc centre of excellence for nanoscale biophotonics AdelaideSA 5005Australia Diabetes Nutrition and Gut HealthLifelong HealthSouth Australia Health and Medical Research InstituteAdelaideSA 5005Australia Department of Gastroenterology and Hepatology Royal Adelaide HospitalAdelaideSA 5000Australia Department of Endocrinology Zhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

The gastrointestinal tract is the key interface between the ingesta and the human *** is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of numerous hormones,is critical to the regulation of appetite,body weight and blood *** concept has led to an increasing focus on“gut-based”strategies for the management of metabolic disorders,including type 2 diabetes and *** the underlying mechanisms and downstream effects of nutrient-gut interactions is fundamental to effective translation of this knowledge to clinical *** this end,an array of research tools and platforms have been developed to better understand the mechanisms of gut hormone secretion from enteroendocrine *** review discusses the evolution of in vitro and in vivo models and the integration of innovative techniques that will ultimately enable the development of novel therapies for metabolic diseases.

关键词： Nutrient-gut interaction Metabolic disorders Incretin hormones Enteroendocrine cells Enteroids Intestinal intubation Intestine-on-a-chip

Mirror-enhanced super-resolution microscopy

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Light(Science & Applications) 2016年第1期5卷 357-364页

作者： Xusan Yang Hao Xie Eric Alonas Yujia Liu Xuanze Chen Philip J Santangelo Qiushi Ren Peng Xi Dayong Jin Department of Biomedical Engineering College of EngineeringPeking UniversityNo.5 Yiheyuan RoadBeijing 100871China Wallace H Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGA 30332USA Advanced Cytometry Labs ARC Centre of Excellence for Nanoscale BioPhotonics(CNBP)Macquarie UniversitySydneyNSW 2109Australia Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia

Axial excitation confinement beyond the diffraction limit is crucial to the development of next-generation,super-resolution *** Emission Depletion(STED)nanoscopy offers lateral super-resolution using a donut-beam depletion,but its axial resolution is still over 500 *** internal reflection fluorescence microscopy is widely used for single-molecule localization,but its ability to detect molecules is limited to within the evanescent field of~100 nm from the cell attachment *** find here that the axial thickness of the point spread function(PSF)during confocal excitation can be easily improved to 110 nm by replacing the microscopy slide with a *** interference of the local electromagnetic field confined the confocal PSF to a 110-nm spot axially,which enables axial super-resolution with all laser-scanning *** sectioning can be obtained with wavelength modulation or by controlling the spacer between the mirror and the *** no additional complexity,the mirror-assisted excitation confinement enhanced the axial resolution six-fold and the lateral resolution two-fold for STED,which together achieved 19-nm resolution to resolve the inner rim of a nuclear pore complex and to discriminate the contents of 120 nm viral *** ability to increase the lateral resolution and decrease the thickness of an axial section using mirror-enhanced STED without increasing the laser power is of great importance for imaging biological specimens,which cannot tolerate high laser power.

关键词： confocal interference point spread function super-resolution

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration Research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

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The Innovation 2021年第2期2卷 139-147页

作者： Hongyuan Li Yinghua Peng Cong Lin Xiaozheng Zhang Tianshu Zhang Yibo Wang Yuanpeng Li Siru Wu Hongshuang Wang Mark RHutchinson Linda RWatkins Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesJilin 130022China Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural SciencesJilin 130112China Discipline of Physiology Adelaide Medical SchoolUniversity of AdelaideAdelaideSAAustralia Department of Psychology and Neuroscience and the Center for NeuroscienceUniversity of Colorado at BoulderBoulderCO 80309USA Department of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China arc centre of excellence for nanoscale biophotonics University of AdelaideAdelaideSA 5000Australia

Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of *** attenuates the neuroinflammation induced by microglial ***,the molecular target(s)underlying anti-inflammatory action of nicotine has not been fully *** the psychoactive substances morphine,cocaine,and methamphetamine act as xenobiotic-associated molecular patterns and can be specifically sensed by the innate immune receptor Toll-like receptor 4(TLR4),here we sought to delineate whether nicotine and/or its metabolite cotinine may be recognized by the innate immune system via myeloid differentiation protein 2(MD2).

关键词： belongs alkaloid system