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Biomarkers of intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease

World Journal of pediatrics 2019年第2期15卷 168-175页

作者： Wei-Xing Kong Fei-Yue Ma Song-Ling Fu Wei Wang Chun-Hong Xie Yi-Ying Zhang Fang-Qi Gong department of Cardiovascular Diseases Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadHangzhou 310052China

Background Currently,there are no reliable indicators for predicting intravenous immunoglobulin resistance and coronary artery lesions in the early stage of Kawasaki *** A total of 300 patients with Kawasaki disease were studied *** data were compared between the intravenous immunoglobulin resistant (29 patients) and responsive groups,and between the groups with coronary artery lesions (48 patients) and without coronary artery *** The intravenous immunoglobulin resistant group had significantly higher D-dimer,globulin,interleukin-6 and serum ferritin levels in comparison to the intravenous immunoglobulin responder group.D-dimer level had a sensitivity of 87.0% and a specificity of 56.3% for predicting intravenous immunoglobulin resistance at a cutoff point of 1.09 mg/*** had a sensitivity of 62.1% and a specificity of 82.3% for predicting intravenous immunoglobulin resistance at a cutoff point of 34.7 g/*** ferritin level had a sensitivity of 42.9% and a specificity of 88.8% for predicting intravenous immunoglobulin resistance at a cutoff point of 269.7 ng/*** patients with coronary artery lesions had higher D-dimer and tumor necrosis factor-α level.D-dimer level had a sensitivity of 50% and a specificity of 78.6% for predicting coronary artery lesions at a cutoff point of 1.84 mg/*** on analysis by multivariate logistic regression,serum ferritin and globulin were independent risks for intravenous immunoglobulin resistance,D-dimer was independent risk for coronary artery *** Elevated serum ferritin,globulin and D-dimer levels are significantly associated with intravenous immunoglobulin resistance in Kawasaki ***,serum D-dimer is significantly increased in Kawasaki disease with coronary artery lesions.

关键词： Biomarkers Coronary artery lesions Intravenous immunoglobulin resistance Kawasaki disease

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Oxidative and nitrosative stress enzymes in relation to nitrotyrosine in Helicobacter pylori-infected humans

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 373-379页

作者： Anders Elfvin Anders Edebo Peter Hallersund Anna Casselbrant Lars Fndriks department of Gastrosurgical Research and Education Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg department of pediatrics Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg

AIM: To compare a possible relation between Helicobacter pylori(H. pylori) and the oxygen- and nitrogen radical system in humans. METHODS: Mechanisms for H. pylori to interfere with the oxygen and nitrogen radical system is of great importance for understanding of the H. pylori persistence and pathogenesis. Biopsies were obtained from the gastric wall of 21 individuals. Ongoing infection with H. pylori was detected using direct analyze from the biopsies using campylobacter-like organism test(CLO-test) and/or by using 14C-urea breath test. The individuals were divided in a negative H. pylori and a positive H. pylori group. Expression in the gastric mucosa of induc-ible nitric oxide syntase(iNOS), nicotinamide adenine dinucleotide phosphate-oxidase(NADPH-oxidase) myeloperoxidase(MPO), and nitrotyrosine were assessed by Western ***: The individuals who undervent gastroscopy were divided in a H. pylori neg. [n = 13, m/f = 7/6, age(mean) = 39] and a H. pylori pos. group [n = 8, m/f = 5/3, age(mean) = 53]. Using western blot analysis iNOS was detected as a 130 kDa band. The iNOS expression was upregulated in the antrum of H. pylori infected individuals in comparison to the controls, mean ± SD being 12.6 ± 2.4 vs 8.3 ± 3.1, P 2.1 ± 1.9, P 2.2 vs 0.3 ± 0.2, P < 0.01. Regarding nitrotyrosine formation, We

关键词： Helicobacter pylori Radical Myeloperoxidase Nicotinamide adenine dinucleotide phosphate Nitrotyrosine Gastric

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Liver fibrosis in biliary atresia

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World Journal of pediatrics 2019年第2期15卷 117-123页

作者： Wen-Jun Shen Gong Chen Min Wang Shan Zheng department of Pediatric Surgery Children's Hospital of Fudan University399 Wanyuan RoadMinhang DistrictShanghai 201102China

Background Biliary atresia (BA) is the most common cause of obstructive jaundice in *** the Kasai procedure has greatly improved the progno sis,most patients still need liver transplantation (LT) for long-term *** pathogenesis of BA has not been fully clarified,and liver fibrosis in BA is far beyond biliary obstructive *** sources Literature reviews were underwent through *** inflammation,immune response,biliary epithelial-mesenchymal transition,matrix deposition,decompensated angiogenesis,and unique biliary structure development all contribute to the fibrosis *** evidences in such fields have been collected and form the backbone of this *** Interactions of the multiple pathways accelerate this *** Understanding the mechanisms of the liver fibrosis in BA may pave the way to improved survival after the Kasai procedure.

关键词： Liver fibrosis Biliary atresia Children

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Bibliometric analysis on retinoblastoma literatures in PubMed during 1929 to 2010

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 115-120页

作者： Zhi-Guang Zhao, Li-Xian Xu department of Urology Tangdu Hospital the Fourth Military Medical University Xi'an 710038 Shaanxi Province China department of Gastroenterology Xijing Hospital the Fourth Military Medical University Xi'an 710032 Shaanxi Province China department of Anatomy and Editorial Office of Chinese Journal of Neuroanatomy the Fourth Military Medical University Xi'an 710032 Shaanxi Province China Outpatient department of Oncology Institute of Tumor the Fourth Military Medical University Xi'an 710032 Shaanxi Province China Anesthesia School of Stomatology the Fourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM: To determine the growth rule and tendency of retinoblastoma (Rb) literature, and to provide the basis for research of diagnosis, treatment and on Rb. METHODS: Bibliometric analyses were carried out on Rb literatures which contain the descriptors of Rb in their titles or texts from 1929 to 2010 in PubMed database (***. ***/Pubmed). The biomedical journals referring to Rb by using bibliometric indicators were calculated. The principal bibliometric indicators, i.e, Price's and Bradford's laws to the increase or distribution of scientific literature, the participation index of languages and the journals were applied. By means of manual coding, Rb documents were classified according to documents studied and to statistical analysis. RESULTS: During 1929-2010, there were 16162 literatures in the PubMed database including the word Rb. According to the literature type, it includes Review (n=2026), Randomized Controlled Trial (n = 7), Practice guideline (n = 3), meta-analysis (n = 4), letter (n = 215), editorial (n = 98), clinical trial (n = 115) and others (n = 13694). By the statistical analysis, its equation is near power index (y = 3.0477 x(2.6088), R(2) = 0.9666). From 1929 to 2010, Rb literatures in English were primarily dominant (90.71%) and the amount of the literature in Chinese ranked the fourth (1.37%). By searching PubMed, 1420 (8.8%) literatures covered were from 41 of 48 ophthalmological, and 406 (2.5%) literatures from 44 of 86 pediatrics journals that correlated with retinoblastoma (SCI-indexed). The data showed that the literatures of Rb were gradually increasing year by year and were approximate near power index during 1929-2010, and the document publishes published mainly in ophthalmological journals, and in English (90.71%), and showing that the study on Rb is a popular subject in the last half century. CONCLUSION: The literatures of Rb are gradually increasing, mainly English in ophthalmologic journals.

关键词： bibliometric analysis biomedical publications retinoblastoma journal literature

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Maternal exposure to antibiotics increases the risk of infant eczema before one year of life:a meta-analysis of observational studies

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World Journal of pediatrics 2020年第2期16卷 143-151页

作者： Fa-Qing Huang Chang-Yu Lu Shi-Ping Wu Shao-Zhi Gong Yan Zhao department of Dermatology Jingzhou First People's HospitalShashi DistrictNo.8 Hangkong RoadJingzhou 434000China

Background There are some conflicting evidences showing that maternal exposure to antibiotics may increase the risk of infant *** present study aims to estimate the effect of prenatal antibiotics administration on infant *** According to the established inclusion criteria,eligible observational studies were collected by comprehensive database *** qualities of the included studies were assessed using the Newcastle-Ottawa *** sizes that were adjusted by multivariable models were extracted and *** bias was evaluated by visual inspection of funnel *** A total of seven observational studies were *** qualities of the included studies were at moderate or high *** antibiotics use was positively associated with eczema before one year of age[odds ratio(OR)=1.93,95%confidence interval(CI)1.35-2.76].In addition,antibiotics exposure in utero was likely to be related to eczema after one year of age(OR 1.21,95%CI 0.98-1.49).The exposure to antibiotics during third trimester was not associated with infant eczema(OR0.97,95%CI 0.86-1.09).Conclusions Maternal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year *** influence of timing of antibiotics exposure during pregnancy needs more studies to clarify.

关键词： Antibiotics Eczema Infant Meta-analysis

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新生猪缺氧缺血性脑损伤模型中脑氧饱和度－时间阈值的研究

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麻醉与镇痛 2011年第5期7卷 92-102页

作者： C. Dean Kurth, MD John C. McCann, BS Jun Wu, MD Lili Miles, MD Andreas W. Loepke, MD, PhD 潘鹏（译） departments of Anesthesiology Pathology and Pediatrics Cincinnati Children＇s Hospital University of Cincinnati College of Medicine Cincinnati Ohio 不详

背景危重新生儿缺氧缺血性脑病（***，H．I）的检测和脑损伤预防是目前的难题。近红外光谱分析（near—infraredspecVoscopy，NIRS）作为一种无创的床边监测技术可以解决上述问题，但是，对于脑损伤中NIRS脑氧饱和度（O，saturation，S... 详细信息

背景危重新生儿缺氧缺血性脑病（***，H．I）的检测和脑损伤预防是目前的难题。近红外光谱分析（near—infraredspecVoscopy，NIRS）作为一种无创的床边监测技术可以解决上述问题，但是，对于脑损伤中NIRS脑氧饱和度（O，saturation，ScO2）的存活力-时间阈值，目前尚不明确。本研究目的是探讨ScO2为35％时的H—I持续时间（引起神经生理障碍的存活力闽值）与神经系统预后的关系。方法46头新生猪，经芬太尼．咪达唑仑麻醉后，放置NIRS及脑功能监测（***，CFM）探头，记录ScO2及脑皮质电活动（eleclrocorticalactivity，ECA）。夹闭颈总动脉后，调节吸入氧浓度复制出H—I模型（ScO2为35％同时伴有ECA降低）。分别于H-I1小时、2小时、3小时、4小时、6小时及8小时后，通过神经行为学及组织病理学评价存活个体的神经系统预后情况。结果H—I持续1小时或2小时，ECA及ScO2在再灌注期很快恢复正常，受试个体的神经功能也恢复至正常水平。H-I持续时间超过2-3小时，再灌注期ECA显著下降，ScO2则明显增加，提示体内存在组织氧代谢持续受抑制。H—I持续时间超过2小时，神经损伤的发生率呈线性增加，约为每小时增加15％。结论ScO2达35％时，H-I损伤的生存一时间阈值为2—3小时，标志为再灌注期NIRS及CFM出现异常。本研究结果提示，联合应用NIRS和CFM有助于预测神经系统的预后，H—I损伤期间存在几个小时的时间窗，可以有效的预防神经功能损伤。

关键词：缺氧缺血性脑损伤模型中脑氧饱和度时间阈值新生猪新生儿缺氧缺血性脑病 ischemia 神经功能损伤近红外光谱分析

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Association between maternal gestational diabetes and allergic diseases in offspring:a birth cohort study

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World Journal of pediatrics 2023年第10期19卷 972-982页

作者： Yu-Jing Chen Li-Zi Lin Zhao-Yan Liu Xin Wang Shamshad Karatela Yu-Xuan Wang Shan-Shan Peng Bi-Bo Jiang Xiao-Xu Li Nan Liu Jin Jing Li Cai department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou 510080Guangdong ProvincePeople’s Republic of China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China department of Nutrition School of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Key Laboratory of Brain Cognition and Education SciencesMinistry of EducationGuangzhouChina Faculty of Health and Behavioural Sciences Pharmacy Australia Centre of ExcellenceUniversity of QueenslandWoolloongabbaQLDAustralia Global Health Research Center Duke Kunshan UniversityKunshanPeople’s Republic of China department of Medical Statistics School of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Institute for Brain Research and Rehabilitation South China Normal UniversityGuangzhouPeople’s Republic of China Institute of Tropical Health and Medicine(AITHM) James Cook UniversityTownsvilleQLDAustralia

Background Previous studies have linked gestational diabetes(GDM)with allergies in ***,the effect of specific glucose metabolism metrics was not well characterized,and the role of polyunsaturated fatty acids(PUFAs),a modifier of metabolism and the immune system,was *** aimed to investigate the association between maternal GDM and allergic diseases in children and the interaction between glucose metabolism and PUFAs on allergic *** This prospective cohort study included 706 mother–child dyads from Guangzhou,*** GDM was diagnosed via a 75-g oral glucose tolerance test(OGTT),and dietary PUFAs were assessed using a validated food frequency *** disease diagnoses and the age of onset were obtained from medical records of children within three years *** Approximately 19.4%of women had GDM,and 51.3%of children had any allergic *** was positively associated with any allergic diseases(hazard ratio[HR]1.40;95%confidence interval(CI)1.05–1.88)and eczema(HR 1.44;95%CI 1.02–1.97).A unit increase in OGTT after two hours(OGTT-2 h)glucose was associated with an 11%(95%CI 2%–21%)higher risk of any allergic diseases and a 17%(95%CI 1–36%)higher risk of food *** positive associations between OGTT-2 h glucose and any allergic diseases were strengthened with decreased dietary a-linolenic acid(ALA)and increased n-6 PUFAs,linoleic acid(LA),LA/ALA ratio,and n-6/n-3 PUFA *** Maternal GDM was adversely associated with early-life allergic diseases,especially *** were the first to identify OGTT-2 h glucose to be more sensitive in inducing allergy risk and that dietary PUFAs might modify the associations.

关键词： Allergic disease Cohort study Eczema Gestational diabetes Polyunsaturated fatty acid

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Downregulated nuclear lncRNA NRON inhibits SHP2/Wnt/β-catenin signaling and cardiomyocyte differentiation during the development of Tetralogy of Fallot

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Genes & Diseases 2023年第3期10卷 750-752页

作者： Hui Zhang Lei Lu Chao Li Hongdou Li Jie Tian Hongyan Wang Zhang Zhongjing School of Chinese Medicine Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for ImmunoregulationNanyang Institute of TechnologyNanyangHenan 473004China department of Cardiology Heart CentreMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing Key Laboratory of Pediatrics China International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200011China Obstetrics and Gynecology Hospital NHC Key Laboratory of Reproduction RegulationShanghai Institute of Planned Parenthood ResearchState Key Laboratory of Genetic Engineering at School of Life SciencesChildren's HospitalFudan UniversityShanghai 200438China

Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart disease and the incidence of late cardiac death in long-term survivors continues to increase.1 So,there is an urgent need to explore the etiology and pathogenesis of *** precise cause of TOF is currently unclear,and exploration of the pathogenesis has focused increasingly in recent years on the roles of noncoding gene products,especially long noncoding RNAs(lncRNAs).

关键词： pathogenesis cardiac congenital

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Kabuki syndrome:review of the clinical features,diagnosis and epigenetic mechanisms

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World Journal of pediatrics 2019年第6期15卷 528-535页

作者： Yi-Rou Wang Nai-Xin Xu Jian Wang Xiu-Min Wang department of Endocrinology and Metabolism Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina department of Genetics Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Huaxi Medical College School of Sichuan University SichuanChina

Background Kabuki syndrome(KS),is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase(KMT2D)or an X-linked histone H3 lysine 27 demethylase(UTX/KDM6A).The characteristics in patients with KS have not yet been well *** sources We used databases including PubMed and Google Scholar to search for publications about the clinical features and the etiology of Kabuki *** most relevant articles to the scope of this review were chosen for *** Clinical diagnosis of KS is challenging in initial period,because many clinical characteristics become apparent only in subsequent ***,the genetic and functional interaction between KS-associated genes and their products have been *** clinical findings were reported including nervous system and intellectual performance,endo-crine-related disorders and immune deficiency and autoimmune *** risks of Kabuki syndrome was ***,we discussed the Kabuki-like *** clinical genetic service,such as dysmorphology database can improve availability and provide high-quality diagnostic *** the significant clinical relevance of KS-associated genes and epigenetic modifications crosstalk,efforts in the research for new mechanisms are thus of maximum *** Kabuki syndrome has a strong clinical and biological *** main pathogenesis of Kabuki syndrome is the imbalance between switch-on and-off of the *** direction of drug research may be to regulate the normal opening of *** molecule inhibitors of histone deacetylases maybe helpful in treatment of mental retardation and reduce cancer risk in KS.

关键词： Kabuki syndrome KMT2D KDM6A Kabuki-like syndrome Cancer risk

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Placental growth factor expression is reversed by anti-vascular endothelial growth factor therapy under hypoxic conditions

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World Journal of pediatrics 2014年第3期10卷 262-270页

作者： Ai-Yi Zhou Yu-Jing Bai Min Zhao Wen-Zhen Yu Lv-Zhen Huang Xiao-Xin Li department of Ophthalmology the Second Affi liated Hospital of Medical College of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Key Laboratory of Vision Loss and Restoration Ministry of EducationDepartment of OphthalmologyPeople's HospitalPeking UniversityBeijingChina

Background:Clinical trials have revealed that the antivascular endothelial growth factor(VEGF)therapies are effective in retinopathy of prematurity(ROP).But the low level of VEGF was necessary as a survival signal in healthy conditions,and endogenous placental growth factor(PIGF)is redundant for *** purpose of this study was to elucidate the PIGF expression under hypoxia as well as the infl uence of anti-VEGF therapy on ***:CoCl2-induced hypoxic human umbilical vein endothelial cells(HUVECs)were used for an in vitro study,and oxygen-induced retinopathy(OIR)mice models were used for an in vivo *** expression patterns of PIGF under hypoxic conditions and the infl uence of anti-VEGF therapy on PIGF were evaluated by quantitative reverse transcription-polymerase chain reaction(RTPCR).The retinal avascular areas and neovascularization(NV)areas of anti-VEGF,anti-PIGF and combination treatments were *** PIGF concentration was evaluated by ELISA after *** vasoactive effects of exogenous PIGF on HUVECs were investigated by proliferation and migration ***:PIGF mRNA expression was reduced by hypoxia in OIR mice,in HUVECs under hypoxia and anti-VEGF ***,PIGF expression was reversed by anti-VEGF therapy in the OIR model and in HUVECs under *** PIGF significantly inhibited HUVECs proliferation and migration under normal conditions,but it stimulated cell proliferation and migration under ***-PIGF treatment was effective for neovascular tufts in OIR mice(P<0.05).Conclusion:The finding that PIGF expression is iatrogenically up-regulated by anti-VEGF therapy provides a consideration to combine it with anti-PIGF therapy.

关键词： human umbilical vein endothelial cells oxygen-induced retinopathy placental growth factor vascular endothelial growth factor

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