Maternal exposure to antibiotics increases the risk of infant eczema before one year of life:a meta-analysis of observational studies

作     者：Fa-Qing Huang Chang-Yu Lu Shi-Ping Wu Shao-Zhi Gong Yan Zhao Fa-Qing Huang;Chang-Yu Lu;Shi-Ping Wu;Shao-Zhi Gong;Yan Zhao

作者机构：Department of DermatologyJingzhou First People's HospitalShashi DistrictNo.8 Hangkong RoadJingzhou 434000China 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2020年第16卷第2期

页      面：143-151页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：Antibiotics Eczema Infant Meta-analysis 

摘      要：Background There are some conflicting evidences showing that maternal exposure to antibiotics may increase the risk of infant *** present study aims to estimate the effect of prenatal antibiotics administration on infant *** According to the established inclusion criteria,eligible observational studies were collected by comprehensive database *** qualities of the included studies were assessed using the Newcastle-Ottawa *** sizes that were adjusted by multivariable models were extracted and *** bias was evaluated by visual inspection of funnel *** A total of seven observational studies were *** qualities of the included studies were at moderate or high *** antibiotics use was positively associated with eczema before one year of age[odds ratio(OR)=1.93,95%confidence interval(CI)1.35-2.76].In addition,antibiotics exposure in utero was likely to be related to eczema after one year of age(OR 1.21,95%CI 0.98-1.49).The exposure to antibiotics during third trimester was not associated with infant eczema(OR0.97,95%CI 0.86-1.09).Conclusions Maternal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year *** influence of timing of antibiotics exposure during pregnancy needs more studies to clarify.