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plant Communications 2024年第7期5卷 251-260页

作者： Peipei Xu Wei Ma Huafeng Feng Weiming Cai Laboratory of Photosynthesis and Environment CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesNo.300 Fenglin RoadShanghai 200032China State Key Laboratory of NBC Protection for Civilian Beijing 102205China department of Food Science College of Hospitality ManagementShanghai Business SchoolShanghai 200235China These authors contributed equally to this article

Freezing stress can seriously affect plant growth and development,but the mechanisms of these effects and plant responses to freezing stress require further ***,we identified a NAM,ATAF1.2,and CUC2(NAC)-family transcription factor(TF),NAC056,that can promote freezing tolerance in ***056 mRNA levels are strongly induced by freezing stress in roots,and the nac056 mutant exhibits compromised freezing ***056 acts positively in response to freezing by directly promoting key C-repeat-binding factor(CBF)pathway ***,we found that CBF1.regulates nitrate assimilation by regulating the nitrate reductase gene NIA1.in plants;therefore,NAC056–CBF1.NIA1.form a regulatory module for the assimilation of nitrate and the growth of roots under freezing *** addition,35S::NAC056 transgenic plants show enhanced freezing tolerance,which is partially reversed in the cbfs triple ***,NAC056 confers freezing tolerance through the CBF pathway,mediating plant responses to balance growth and freezing stress tolerance.

关键词： CBFs freezing tolerance NAC transcription factor nitrate assimilation root growth

Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVENTOMICS intervention

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Food Science and Human Wellness 2024年

作者： Sebastià Galmés Andreu Palou-March Kristina Pigsborg Mona Adnan Aldubayan Sophia M.O.Gormsen Alberto Calleja Joan Trabal Vanesa Martínez Biotza Gutiérrez Josep M.Del Bas Faidon Magkos Francisca Serra Eurecat， Centre tecnològic de Catalunya， Biotechnology Area Avd Universitat 1 Laboratory of Molecular Biology， nutrition and Biotechnology (Nutrigenomics， Biomarkers and Risk Evaluation-NuBE)， University of the Balearic Islands Health Research Institute of the Balearic Islands (IdISBa) CIBER of Physiopathology of Obesity and nutrition (CIBEROBN)， Carlos III Health Institute (ISCIII) Alimentómica S.L.， Camí de na Pontons.s/n (Pol.1.，Parc 3) department of {1.， Exercise and Sports， Faculty of Science， University of Copenhagen department of Clinical {1.， College of Applied Medical Sciences， King Saud bin Abdulaziz University for Health Sciences R&D， Food & Culinary department Simple Feast Leitat Technological Center C/Innovació 2 Creaciones Aromáticas Industriales SA， Cuatrecasas i Arumí， Sant Quirze del Valles

Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements. This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals. Therefore， we assessed here the usefulness of a polygenic score (PGS) characterizing a potential pro-inflammatory profile (PGSi) as a nutrigenetic tool to discern individuals from the Danish PREVENTOMICS cohort that could better respond to precision nutrition (PN) plans， specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity. The cohort followed a PN plan to counteract the pro-inflammatory profile (PNi group) or generic dietary recommendations (Control) for 1. weeks. PGSi was applied for genetic stratification (Low/High). The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed. Around 30% of subjects had a high genetic predisposition to pro-inflammatory status (high-PGSi). These individuals demonstrated the most effective response to the dietary plan， experiencing improved body composition， with significant decreases in body weight (△: -4.84%; p=0.039) and body fat (△: -4.86%; p=0.007)， and beneficial changes in pro- and anti-inflammatory biomarkers， with significant increases in IL-1. (△: 71.3%; p=0.025) and decreases in TNF-α (△: -3.0%; p=0.048)， CRP (△: -31.1.)， ICAM1.(△: -5.8%)， and MCP1.(△: -4.2%) circulating levels， compared to low-PGSi individuals. Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet. This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.

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Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats

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Food Science and Human Wellness 2024年第5期13卷 2562-2572页

作者： Nan Shang Xiaoyu Bao Michael Doschak Jianping Wu department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada College of Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Precision nutrition and Food Quality Department of Nutrition and HealthyChina Agricultural UniversityBeijing 100193China Faculty of Pharmacy&Pharmaceutical Sciences University of AlbertaEdmonton T6G 2H5Canada

Ovotransferrin,an iron-binding glycoprotein,accounting for approximately 1.%of egg white protein,is a member of transferrin fam *** previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts,while inhibits osteoclastogenesis and resorption *** work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized(OVX)Sprague-Dawley *** administration of ovotransferrin showed no negative effect on body weight,food intake and organ *** 1.-week treatment,feeding ovotransferrin at a dose of 1.(1.g ovotransferrin/1.0 g diet)prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone *** serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups,while the bone resorption biomarkers were *** feeding also decreased the production of serum cytokine TNF-αand IL-6,which are two stimulators for osteoclast *** addition to its direct regulatory role on bone turnover,ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis,and regulating immune *** results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.

关键词： Ovotransferrin Ovariectomized(OVX)rats Bone mineral density Bone microarchitecture Bone resorption Inflammation

A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants

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Science China(Life Sciences) 2024年第6期67卷 1280-1291页

作者： Yong Zhang Xiaotuo Zhang Qi Tang Lei Li Ting Jiang Yixiao Fang Hong Zhang Jixian Zhai Guodong Ren Binglian Zheng State Key Laboratory of Genetic Engineering Institute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China

Lariat RNA is concomitantly produced by excised intron during RNA splicing,which is usually debranched by DBR1.an RNA debranching ***,increasing evidence showed that some lariat RNA could escape *** is known about how and why these lariat RNAs could be *** comparing the atlas of lariat RNAs between the non-dividing cell(mature pollen)and three actively dividing tissues(young shoot apex,young seeds,and young roots),we identified hundreds to thousands of lariat RNA naturally retained in each tissue,and the incidence of lariat RNA retention is much less in shoot apex while much more in *** lariat RNAs derived from the same intron or different lariat RNAs from the same pre-m RNA could be retained in one tissue while degraded in the other *** deciphering lariat RNA sequences,we identified an AG-rich(RAAAAVAAAR)motif and a UC-rich(UCUCUYUCUC)motif for pollen-specific and the other three tissues-retained lariat RNAs,*** of the pollen-specific AG-rich motif indeed enhanced lariat RNA retention in ***,hundreds of lariat RNAs harbored mi RNA binding sites,and dual-luciferase reporter assay showed that these natural lariat RNAs had the potential to protect expression of mi RNA target ***,our results uncover that selective retention of lariat RNA is an actively regulatory process,and provide new insights into understanding how lariat RNA metabolism may impact mi RNA activity.

关键词： intron turnover lariat RNA miRNA RNA splicing DBR1

Callus proliferation-induced hypoxic microenvironment decreases shoot regeneration competence in Arabidopsis

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Molecular plant 2024年第3期17卷 395-408页

作者： Dohee Koo Hong Gil Lee Soon Hyung Bae Kyounghee Lee Pil Joon Seo department of Chemistry Seoul National UniversitySeoul 08826Korea plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea

plants are aerobic organisms that rely on molecular oxygen for respiratory energy *** conditions,with oxygen levels ranging between 1.and 5%,usually limit aerobic respiration and affect plant growth and ***,we demonstrate that the hypoxic microenvironment induced by active cell proliferation during the two-step plant regeneration process intrinsically represses the regener-ation competence of the callus in Arabidopsis *** showed that hypoxia-repressed plant regener-ation is mediated by the RELATED TO APETALA2.1.(RAP2.1.)protein,a memberof the Ethylene Response Factor VIl(ERF-Vll)*** found that the hypoxia-activated RAP2.1. protein promotes salicylic acid(SA)biosynthesis and defense responses,thereby inhibiting pluripotency acquisition and de novo shoot regeneration in *** and genetic analyses revealed that RAP2.1. could bind directly to the SALICYLIC ACID INDUCTION DEFICIENT 2(SID2)gene promoter and activate SA biosynthesis,repressing plant regeneration possibly via a PLETHORA(PLT)-dependent ***,the rap2.1. mutant calli exhibits enhanced shoot regeneration,which is impaired by SA *** together,these find-ings uncover that the cell proliferation-dependent hypoxic microenvironment reduces cellular pluripotency and plant regeneration through the RAP2.1.-SID2 module.

关键词： callus cell proliferation-induced hypoxia SID2 plant regeneration salicylic acid RAP2.1.

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China department of Food Science and {1. The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1.and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1.and NQO-1.***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1.inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases

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Molecular plant 2024年第5期17卷 824-837页

作者： Tom Schreiber Anja Prange Petra Schafer Thomas Iwen Ramona Grutzner Sylvestre Marillonnet Aurelie Lepage Marie Javelle Wyatt Paul Alain Tissier department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in *** this study,we identified two groups of exonucleases from the herpes virus and the bacteriophage T7 families that conferred an up to 38-fold increase in homology-directed repair frequencies when fused to Cas9/Cas1.a in a tobacco mosaic virus-based transient assay in Nicotiana *** achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable transformation *** Arabidopsis thaliana,fusion of Cas9 to a herpes virus family exonuclease led to 1.-fold higher frequencies of knock-ins in the first generation of *** addition,we demonstrated stable and heritable knock-ins in wheat in 1.of the primary *** together,our results open perspectives for the routine production of heritable knock-in and gene replacement events in plants.

关键词： homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease plants

Dietary supplementation with Neolamarckia cadamba leaf extract improves broiler meat quality by enhancing antioxidant capacity and regulating metabolites

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Animal nutrition 2024年第02期17卷 358-372页

作者： Cheng Wang Dandan Chen Shou Wu Wei Zhou Xiaoyang Chen Qing Zhang Li Wang State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences College of Forestry and Landscape Architecture Guangdong Province Research Center of Woody Forage Engineering TechnologyGuangdong Research and Development Center of Modern Agriculture (Woody Forage) Industrial TechnologyGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresourcesSouth China Agricultural University

This study was to evaluate the effect of supplementing the diet of broilers with Neolamarckia cadamba leaf extract(NCLE) on meat quality by evaluating antioxidant parameters and the expression of genes in the p38 mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element(p38 MAPK/Nrf2/ARE) signaling pathway, coupled with LC-MS-based metabolomic analysis. A total of 480 one-day-old male broilers were randomly allocated to four treatment groups—a control(CON)group, which was fed a basal diet, and three NCLE treatment groups, which were fed the basal diet supplemented with 1.0, 200, or 400 mg/kg NCLE(N1. N2, and N3 groups, respectively) for 42 d. Compared with the CON group, meat quality was improved in the N2 and N3 groups, as evidenced by the higher p H45min(P 1.2(ERK1.2), c-Jun N-terminal kinase(JNK), Nrf2, CAT, and GSH-Px(P 1.4-lactone and lyso-PAF C-1.-d4 were negatively correlated with shear force and cooking loss(P 1.6-diphosphate contents were downregulated in the three NCLE groups. Finally, the differential metabolites in both BM and LM were involved in amino acid metabolism pathwa

关键词： Neolamarckia cadamba leaf extract Broiler Meat quality Antioxidant capacity Metabolomics

Japanese candlestick charts for diabetes

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World Journal of Methodology 2024年第2期14卷 167-171页

作者： Diana Boj-Carceller department of Endocrinology and {1. Miguel Servet University HospitalZaragoza 50009Spain

Continuous glucose monitoring(CGM)is a popular technology among the diabetic population,especially in patients with type 1.diabetes and those with type 2 diabetes treated with *** American Diabetes Association recommends standardization of CGM reports with visual cues,such as the ambulatory glucose ***,interpreting this report requires training and time for CGM to be *** this work it has been proposed to incorporate Japanese candlestick charts in glucose *** graphs are used in price analysis in financial markets and are easier to *** candle provides extra information to make prudent decisions since it reports the opening,maximum,minimum and closing glucose levels of the chosen time frame,usually the daily *** Japanese candlestick chart is an interesting tool to be considered in glucose *** graphic representation allows identification of glucose trends easily through the colors of the candles and maximum and minimum glucose values.

关键词： Japanese candlestick chart Candlestick chart Ambulatory glucose profile Glucose monitoring Continuous glucose monitoring Hypoglycemia

pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian Xiaofeng He Xiao Wu Dongxue Hu Qing-Hua Xu department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy