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Open Journal of obstetrics and {1. 2015年第5期5卷 244-250页

作者： A. Natalia H. Galadanci S. A. Ibrahim Z. Mohammad Bayero University Kano Nigeria department of {1. and Gynaecology Aminu Kano Teaching Hospital Kano Nigeria

Of all the methods available for the management of first trimester miscarriages, manual vacuum aspiration is the safest, cheapest and fastest. However, pain caused by manipulation of cervix and uterine suction makes it uncomfortable. We compared the clinical effectiveness and adverse effects of combination of non-selective COX inhibitor (Diclofenac Sodium 50 mg) and opioid (Pentazocine 60 mg) to commonly used opiod only (Pentazocine 60 mg) in daily practice of pain management for the treatment of incomplete abortion with manual vacuum aspiration. This was a randomized double-blind controlled trial conducted in Gynaecological Emergency clinic of Aminu Kano Teaching Hospital Kano, Nigeria. Comparison of the level of pain experienced during the procedure revealed statistically significant difference in the level of pain reported among the groups (P-value 0.03). Comparison of severity of pain perception and patients’ satisfaction was found to be negatively related (P 1.. The present study shows that the use of combined analgesia compared to single agent analgesia during MVA is more, safe, significantly reduced pain and improved patient satisfaction during the procedure.

关键词： Analgesia Manual Vacuum Aspiration Miscarriage Pain Pain Management

Risk factors associated with emergency peripartum hysterectomy

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Chinese Medical Journal 2014年第5期127卷 900-904页

作者： JinRong Guo Yuna Chen Yan department of {1. International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of MedicineShanghai 200030 China

Background Use of an emergency peripartum hysterectomy （EPH） as a lifesaving measure to manage intractable postpartum hemorrhage （PPH） appears to be increasing recently around the world,and the indications for EPH have *** object of this study is to identify risk factors associated with *** We conducted a case-control study of 21.patients who underwent EPH because of intractable PPH between January 1.2005 and June 30,201.,at the International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University,School of Medicine （IPMCH）.The parametric t-test,chi-square tests and Logistic regression models were used for analysis to identify the risk *** results were considered statistically significant when P＜*** There were 89 1.8 deliveries during the study ***-one women had an EPH,with an incidence of 24 per 1.0 000 *** loss of blood during postpartum hemorrhage of the EPH group was （5 060.7±3 032.6）ml,and that of the control group was （2 040.8±723.5） *** was a significant difference of PHH between the EHP group and the control group （P=0.001..Independent risk factors for EPH from a logistic regression model were：disseminated intravascular coagulation （DIC）（OR：9.9,95％ CI 2.8-34,P=0.003）,previous cesarean section （OR：5.27;95％ CI：1.48-1..9,P=0.009）,placenta previa （OR：6.9; 95％ CI 1.6-2.9,P=0.008）,the loss of PPH （OR：1.001. 95％ CI 1.001.1.002,P=0.002）,placenta accreta （OR：68; 95％ CI 1.-456,P=0.004）,the use of tocolytic agents prenatally （OR：6.55,95％CI 1.34-32.1.P=0.049）,and fetal macrosomia （OR：6.9,95％ CI 1.25-38,P=0.049）.Conclusion Significant risk factors of EPH are DIC,placenta previa,PPH,previous cesarean delivery,and placenta accrete,the use of tocolytic agents prenatally,and fetal macrosomia.

关键词： emergency peripartum hysterectomy postpartumhemorrhage placenta accrete previous cesarean delivery tocolytic

The E3 ubiquitin ligase,MKRN2,regulates somatic-germ cell adherens junction by palladin degradation in mice

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The E3 ubiquitin ligase,MKRN2,regulates somatic-germ cell ad...

Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Bo Zheng Cong Shen Jun Yu Hong Li Mingxi Liu Center for Reproduction and Genetics Suzhou Municipal HospitalNanjing Medical University Affiliated Suzhou Hospital State Key Laboratory of Reproductive Medicine Nanjing Medical University department of {1. and gynecology Affiliated Hospital of Jiangsu UniversityJiangsu University

Somatic-germ cell adherens junction(AJ) controls a process of sperm release from seminaferous epithelium which is named ’Spermiation’.Spermiation failure results in azoospermia and cause of male *** previous study has showed that MKRN2 is highly expressed in mice testes,and deficiency of MKRN2 in mice causes spermiation ***,the underlying mechanism of how MKRN2 regulates spermiation remains ***,we reported that MKRN2 with an E3 ubiquitin-protein ligase,and was co-located with palladin,a specialized adherens junction(AJ) junction associated protein in testis and could interacted with palladin both in vivo and *** addition,overexpression of MKRN2 could reduce palladin amount and defect palladin ***,we found MKRN2 ubiquitinated palladin by K48-linked ubiquitin *** together,our study uncovers a novel E3 ubiquitin ligase pathway that regulates somaticgerm cell adherens junction(AJ).

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World Journal of Clinical Cases 2024年第23期12卷 5366-5373页

作者： Ze-Ning Shi Xin Zhang Chun-Yuan Du Bing Zhao Shu-Gang Liu department of Pediatrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina department of Anesthesiology Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina department of {1. and obstetrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Neonatal respiratory distress syndrome(NRDS)is one of the most common diseases in neonatal intensive care units,with an incidence rate of about 7%among ***,it is a leading cause of neonatal death in hospitals in *** main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant AIM To explore the effect of pulmonary surfactant(PS)combined with noninvasive positive pressure ventilation on keratin-1.(KRT-1.)and endothelin-1.ET-1.levels in peripheral blood and the effectiveness in treating *** Altogether 1.7 neonates with respiratory distress syndrome treated in our hospital from April 201. to July 2021.were *** these,64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure *** expression of KRT-1. and ET-1.in the two groups was *** deaths,complications,and PaO_(2),PaCO_(2),and PaO_(2)/FiO_(2)blood gas indexes in the two groups were *** operating characteristic curve(ROC)analysis was used to determine the diagnostic value of KRT-1. and ET-1.in the treatment of *** The observation group had a significantly higher effectiveness rate than the control *** was no significant difference between the two groups in terms of neonatal mortality and adverse reactions,such as bronchial dysplasia,cyanosis,and shortness of *** treatment,the levels of PaO_(2)and PaO_(2)/FiO_(2)in both groups were significantly higher than before treatment,while the level of PaCO_(2)was significantly *** treatment,the observation group had significantly higher levels of PaO_(2)and PaO_(2)/FiO_(2)than the control group,while PaCO_(2)was notably lower in the observation *** treatment,the KRT-1. and ET-1.levels in both groups were significantly decreased compared with the pre-treatment *** observation group had a reduction of KRT-1. and ET-

关键词： Pulmonary surfactant Non-invasive positive pressure ventilation Neonatal respiratory distress syndrome Keratin-1. Endothelin-1

The Effect of Age on Male Infertility in Gabon

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Advances in Reproductive Sciences 2023年第4期11卷 127-139页

作者： Makoyo Komba Opheelia Lionel Wildy Moungala Ulysse Minkobame Pamphile Assoumou Alain Boulende Jean Francois Meye Departement of obstetrics and Gynaecology Mother and Child University Hospital of Libreville Libreville Gabon Androcryos Andrology Laboratory Departement of Obstetrics and Gynaecology University of Witwatersand Johannesburg South Africa Reproductive Biology Laboratory Department of Obstetrics and Gynaecology Mother and Child University Hospital of Libreville Libreville Gabon

Background: Male age significantly affects semen parameters. However, there is no evidence on the impact of aging on semen quality in men residing in Libreville, Gabon. Objective: To determine the effects of age on semen quality of patients visiting the Reproductive Laboratory at the Academic Hospital Mère Enfant located in Libreville, Gabon. Methods: This descriptive and prospective study was performed between the 1.t of October 2021.and 30st of September 2022. This study involved patients who had semen analysis as part of fertility check-up. Semen analysis was performed following the World Health Organization, 201. guidelines. Semen parameters such as volume, leucocytes count, sperm concentration, sperm motility, norml morphology and vitality were used in the current study. Descriptive statistics were performed. The Chi-square test and the Fisher test were used as statistical tools for the analysis of data. The ROC curve was used to illustrate the data. Results: A total of 1.8 patients were included in the study. Male infertility prevalence was 77.03%. The average age was 41.years with minimum and maximum of 24 and 61.years respectively. Secondary infertility was predominant (66.9%). Patients displaying asthenozoospermia (22.3%) followed by those displaying oligoasthenozoospermia (OAT) isolated (1.4%) or not (1..6%) were the most frequent semen parameter abnormalities. Men aged more than 45 years were 4.4 times likely to have abnormal semen parameters. Odd = 4.4 (IC 95% = [3.3 - 1..7]). Staphylococcus haemolyticus infection was more prevalent. Conclusion: Male age was found to significantly influence semen quality.

关键词： Gabon Infertility Semen Analysis

Are neonatal morbidities associated with no prenatal care different from those associated with inadequate prenatal care?

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Open Journal of obstetrics and {1. 2012年第2期2卷 89-97页

作者： Ekwutosi M. Okoroh Dean V. Coonrod Kristina Chapple David Drachman Consultant 9239 E. Desert View Scottsdale USA department of {1. Gynecology & Women’s Health Maricopa Integrated Health System and University of Arizona College of Medicine Phoenix USA department of Research Maricopa Integrated Health System Phoenix USA Division of Blood Disorders National Center for Birth Defects and Developmental Disorders Atlanta USA

Objective: Compare neonatal morbidities in women with no prenatal care, and women with inadequate prenatal care, to those with adequate prenatal care. Methods: Retrospective cohort study of neonatal morbidities of 3 exposure groups. Group 1. No prenatal care;Group 2: Inadequate prenatal care;Group 3: Intermediate/adequate prenatal care. Results: 2.5%, 23.3% and 74.1. of subjects (N = 264,1.8) were in Groups 1. 2 and 3 respectively. Severe neonatal morbidity was more common in Group 1. followed by Group 2, and least common in Group 3. After controlling for gestational age and birth weight, most of these differences were attenuated and not significant except for the following Group 1.vs Group 3 comparisons: meconium aspiration, odds ratio (OR) 2.1. and 95% confidence interval (CI) 1.39 - 3.33;suspected sepsis, OR 1.30 and CI 1.1. - 1.49;proven viral sepsis, OR 2.23 and CI 1.24 - 4.00. Conclusions: Severe neonatal morbidity was most common in those with no prenatal care followed by those with inadequate prenatal care. For most neonatal morbidities, this could largely be explained by gestational age and birth weight differences, but for some neonatal morbidities (meconium aspirations, viral sepsis and dysmorphic features) the impact of no prenatal care persisted after adjustment for these factors.

关键词： Prenatal Care Neonatal Outcomes Retrospective Cohort Study

Mass testing—An underexplored strategy for COVID-1. control

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The Innovation 2021年第2期2卷 137-138页

作者： Mingwang Shen Yanni Xiao Guihua Zhuang Yan Li Lei Zhang China-Australia Joint Research Center for Infectious Diseases School of Public HealthXi’an Jiaotong University Health Science CenterXi’an 710061China School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China department of Population Health Science and Policy Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA department of {1. Gynecologyand Reproductive ScienceIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Melbourne Sexual Health Centre Alfred HealthMelbourneVICAustralia Central Clinical School Faculty of MedicineNursing and Health SciencesMonash UniversityMelbourneVICAustralia department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001China

Mass testing is an intervention strategy for COVID-1. control in the general population regardless of the presentation of *** involves collecting nasal or pharyngeal swabs for DNA testing,often using the polymerase chain reaction *** that have used mass testing consider it to be a viable strategy to control the COVID-1. pandemic as the strategy can potentially identify and isolate asymptomatic cases in the early stages of infection and reduce the risk of virus *** the reopening of Wuhan,China,in early April 2020,China has conducted mass testings in three megacities with populations of over 1. million,including Beijing and Qingdao1.at the beginning of their local outbreaks,and Wuhan immediately after the reopening.

关键词： testing strategy Wuhan

IL-27 Triggers IL-1. Production in Th1. Cell by c-Maf/RORγt/Blimp-1.Signal to Promote the Progress of Endometriosis

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IL-27 Triggers IL-10 Production in Th17 Cell by c-Maf/RORγt...

Prior Preterm Birth and Birthweight Below the 5 th Percentile are Independent Risk Factors for Recurrence of a Small for Gestational Age Neonate

第十一届全国免疫学学术大会

作者： Li Ming-Qing Chang Kai-Kai Zhou Wen-Jie Yang Hui-Li Jin Li-Ping Li Da-Jin Laboratory for Reproductive Immunology Hospital of Obstetrics and GynecologyFudan University Clinical and Translational Research Center Shanghai First Maternity and Infant HospitalTongji University School of Medicine

Endometriosis is an estrogen-dependent inflammatory *** anti-inflammatory cytokine IL-1. also increased in ***,the mechanism for origination and role of IL-1. in endometriosis was still large *** we report IL-1.Th1. cells are significantly increased in the peritoneal fluid of women with endometriosis,along with elevation of IL-27,IL-6 and TGF-β.Compared to peripheral CD4 T,endometrial CD4T highly expressed IL-27 receptors,especially ectopic *** external(2,3,7,8-tetrachlorodibenzo-p-dioxin,TCDD) and local(estrogen,IL-6 and TGF-β) environmental regulation,IL-27 from macrophage and endometrial stromal cells(ESC) induces IL-1. produce in Th1. cells in vitro and in *** process is mediated through the interaction between c-musculoaponeuroticfibrosarconma(c-Maf) and retinoic acid-related orphan receptor gamma t(RORγt),and associated with the up-regulation of downstream B lymphocyte-induced maturation protein-1.Blimp-1..Such IL-1.Th1. cells in turn stimulate the proliferation and implantation of ectopic lesion and accelerate the progress of *** results suggest that IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th1. to produce IL-1. and promote rapid growth and implantation of ectopic *** provides a scientific basis on which potential therapeutic strategies targeted to prevent the development of endometriosis,especially for patient with high level of IL-1.Th1. cells.

关键词： IL-27 IL-1.+Th1. endometriosis c-Maf RORγt Blimp-1

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Maternal-Fetal Medicine 2020年第1期2卷 28-33页

作者： Mor Svorai Barak Aricha Offer Erez School of Medicine Faculty of Health SciencesBen Gurion University of the NegevBeer Sheva 84101Israel department of {1. and gynecology Soroka University Medical CenterSchool of MedicineFaculty of Health SciencesBen Gurion University of the NegevBeer Sheva 84101Israel

Objective::This study aimed to determine:(1.whether recurrent deliveries of a small for gestational age(SGA)neonate are associated with increased obstetrical or neonatal complications;(2)whether the risk factors that can predict small for gestational age(SGA)***::This study was based on Soroka Medical Center's obstetrics electronic *** database consisted of 1.9022 women who had 320932 deliveries between the year *** study cohort included 6.8%(7368/1.9022)of these patients who gave birth to a singleton SGA neonate on their first delivery and had more than one *** study population was divided into two groups according to the outcome of the subsequent delivery:(1.women with sporadic SGA who delivered a non-SGA neonate(n=541.);(2)women with recurrent SGA(n=1.52).SGA defined as birthweight1. th *** and neonatal complications were compared between the two *** regression was used to determine independent risk factors for SGA ***::The prevalence of birthweight1..Bedouin ethnicity was more prevalent in the recurrent SGA group(P1..The rate of preterm delivery was higher in the first delivery of the recurrent SGA group(P=0.01.).The sporadic SGA group had a higher rate of perinatal mortality during the first pregnancy(P=0.01.).The rate of severe hypertension(P=0.005),polyhydramnios,meconium-stained amniotic fluid,nonreassuring fetal heart rate and total perinatal mortality(P1.were higher in the second delivery of the recurrent SGA *** a logistic regression model,preterm delivery and birthweight1.530,confidence interval:1.249-1.875;relative risks:1.826,confidence interval:1.641.2.030,respectively).Conclusion::Women with recurrent SGA neonates ha

关键词： Fetal growth retardation Maternal outcome Neonatal outcome Recurrence Risk factor Small for gestational age

Mistaken Oophorectomy in an Adolescent with McCune-Albright Syndrome: A Case Report and Literature Review

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Reproductive and Developmental Medicine 2018年第4期2卷 252-255页

作者： Jun Guan Hai-Yun Guan Lu Wang Wei Zhang department of {1. Campus Virchow ClinicCharite Medical University of BerlinCorporate Member of Free University of BerlinHumboldt University of Berlinand Berlin Institute of HealthBerlinGermany Tumor Bank Ovarian Cancer Network BerlinGermany department of Gynecological Endocrinology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

McCune-Albright syndrome(MAS)is a rare disease characterized by caféau lait spots,bone fibrous dysplasia,and precocious *** MAS cases are diagnosed before ***,we reported an adolescent girl underwent mistaken oophorectomy for suspected ovarian tumor,and later,she was diagnosed with *** 1.-year-old girl was found to have an irregular pelvic mass measuring 9.74 cm×9.01.cm×7.30 cm with a cyst-solid component and a clear boundary by magnetic resonance *** underwent right oophorectomy for the suspected ovarian ***,histopathological examination showed ovarian tissue with many antral *** week after the surgery,ultrasonography revealed a left pelvic irregular echo-free mass measuring 60 mm×53 mm×48 *** patient was then examined by endocrine specialists,and caféau lait spots were found predominantly located on the right side of her waist,hip,and *** had her first period before the surgery,and her serum concentrations of sex hormones were ***,MAS was *** patient has been taking dydrogesterone 20 mg/d for 1. days from the 1.th day of her period for 2 *** performed every 3-6 months revealed no enlargement of her left *** of MAS and careful physical and imaging examination should be emphasized,even in the absence of full classic triad of ***,unnecessary oophorectomy and irreversible loss of fertility potential can be avoided in these patients.

关键词： Adolescent with McCune-Albright Syndrome Caféau lait Spots Diagnosis Mistaken Oophorectomy