Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome
作者机构：Department of PediatricsArmy Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of AnesthesiologyArmy Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of Gynecology and ObstetricsArmy Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2024年第12卷第23期
页 面：5366-5373页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Pulmonary surfactant Non-invasive positive pressure ventilation Neonatal respiratory distress syndrome Keratin-14 Endothelin-1
摘 要：BACKGROUND Neonatal respiratory distress syndrome(NRDS)is one of the most common diseases in neonatal intensive care units,with an incidence rate of about 7%among ***,it is a leading cause of neonatal death in hospitals in *** main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant AIM To explore the effect of pulmonary surfactant(PS)combined with noninvasive positive pressure ventilation on keratin-14(KRT-14)and endothelin-1(ET-1)levels in peripheral blood and the effectiveness in treating *** Altogether 137 neonates with respiratory distress syndrome treated in our hospital from April 2019 to July 2021 were *** these,64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure *** expression of KRT-14 and ET-1 in the two groups was *** deaths,complications,and PaO_(2),PaCO_(2),and PaO_(2)/FiO_(2)blood gas indexes in the two groups were *** operating characteristic curve(ROC)analysis was used to determine the diagnostic value of KRT-14 and ET-1 in the treatment of *** The observation group had a significantly higher effectiveness rate than the control *** was no significant difference between the two groups in terms of neonatal mortality and adverse reactions,such as bronchial dysplasia,cyanosis,and shortness of *** treatment,the levels of PaO_(2)and PaO_(2)/FiO_(2)in both groups were significantly higher than before treatment,while the level of PaCO_(2)was significantly *** treatment,the observation group had significantly higher levels of PaO_(2)and PaO_(2)/FiO_(2)than the control group,while PaCO_(2)was notably lower in the observation *** treatment,the KRT-14 and ET-1 levels in both groups were significantly decreased compared with the pre-treatment *** observation group had a reduction of KRT-14 and ET-
维普期刊数据库